MCL coexpression mm9:452

Phase1 CAGE Peaks

	Short description
Mm9::chr10:19311758..19311893,+	p1@Ifngr1
Mm9::chr15:76073831..76073878,-	p1@Parp10
Mm9::chr17:34324273..34324290,-	p1@Psmb9
Mm9::chr17:34324296..34324325,-	p2@Psmb9
Mm9::chr17:34324734..34324773,+	p1@Tap1
Mm9::chr17:34335287..34335329,+	p1@Psmb8
Mm9::chr17:34335330..34335345,+	p2@Psmb8
Mm9::chr17:34341452..34341518,+	p1@Tap2
Mm9::chr19:46380069..46380117,-	p1@uc008hss.1
Mm9::chr5:38871392..38871478,-	p1@Slc2a9
Mm9::chr6:125181666..125181707,-	p2@Tapbpl
Mm9::chr6:54766777..54766813,+	p3@Znrf2
Mm9::chr7:4610585..4610628,-	p1@Ppp6r1
Mm9::chr8:123260252..123260264,+	p1@Irf8
Mm9::chr8:91159958..91160015,-	p1@Snx20
Mm9::chr9:95855239..95855262,+	p2@Xrn1

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0002376	immune system process	0.000126456316580598
GO:0006955	immune response	0.000216050847144709
GO:0019882	antigen processing and presentation	0.000216050847144709
GO:0015198	oligopeptide transporter activity	0.000239109370773241
GO:0015197	peptide transporter activity	0.000239109370773241
GO:0006857	oligopeptide transport	0.000239109370773241
GO:0005839	proteasome core complex (sensu Eukaryota)	0.00124764663859537
GO:0004298	threonine endopeptidase activity	0.00133988942907512
GO:0000502	proteasome complex (sensu Eukaryota)	0.00213944119925394
GO:0015833	peptide transport	0.00357056488411637
GO:0043231	intracellular membrane-bound organelle	0.0067041546691773
GO:0043227	membrane-bound organelle	0.0067041546691773
GO:0022804	active transmembrane transporter activity	0.00816039369193958
GO:0004534	5'-3' exoribonuclease activity	0.0143469667541324
GO:0043229	intracellular organelle	0.0143469667541324
GO:0043226	organelle	0.0143469667541324
GO:0043492	ATPase activity, coupled to movement of substances	0.0143469667541324
GO:0042626	ATPase activity, coupled to transmembrane movement of substances	0.0143469667541324
GO:0016820	hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances	0.0143469667541324
GO:0006511	ubiquitin-dependent protein catabolic process	0.0143469667541324
GO:0019941	modification-dependent protein catabolic process	0.0143469667541324
GO:0043632	modification-dependent macromolecule catabolic process	0.0143469667541324
GO:0051603	proteolysis involved in cellular protein catabolic process	0.0143469667541324
GO:0044257	cellular protein catabolic process	0.0143469667541324
GO:0015399	primary active transmembrane transporter activity	0.0143469667541324
GO:0015405	P-P-bond-hydrolysis-driven transmembrane transporter activity	0.0143469667541324
GO:0019883	antigen processing and presentation of endogenous antigen	0.0143469667541324
GO:0002483	antigen processing and presentation of endogenous peptide antigen	0.0143469667541324
GO:0019885	antigen processing and presentation of endogenous peptide antigen via MHC class I	0.0143469667541324
GO:0044444	cytoplasmic part	0.0158273200625474
GO:0016787	hydrolase activity	0.0162258501755409
GO:0008409	5'-3' exonuclease activity	0.0162484168177538
GO:0030163	protein catabolic process	0.0225127277997454
GO:0005783	endoplasmic reticulum	0.0281356080350887
GO:0005355	glucose transmembrane transporter activity	0.0296747923763085
GO:0015145	monosaccharide transmembrane transporter activity	0.0308702147567943
GO:0015149	hexose transmembrane transporter activity	0.0308702147567943
GO:0042623	ATPase activity, coupled	0.0310720046932331
GO:0044265	cellular macromolecule catabolic process	0.0310720046932331
GO:0043285	biopolymer catabolic process	0.0313768624398188
GO:0007569	cell aging	0.0313768624398188
GO:0016896	exoribonuclease activity, producing 5'-phosphomonoesters	0.0313768624398188
GO:0004532	exoribonuclease activity	0.0313768624398188
GO:0044424	intracellular part	0.0326666036173901
GO:0005887	integral to plasma membrane	0.0335838026201669
GO:0016887	ATPase activity	0.0335838026201669
GO:0031226	intrinsic to plasma membrane	0.0335838026201669
GO:0022857	transmembrane transporter activity	0.0335838026201669
GO:0005622	intracellular	0.0335838026201669
GO:0005737	cytoplasm	0.0335838026201669
GO:0032200	telomere organization and biogenesis	0.0338962854418947
GO:0000723	telomere maintenance	0.0338962854418947
GO:0016796	exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	0.0352043359394095
GO:0002474	antigen processing and presentation of peptide antigen via MHC class I	0.0364253721357344
GO:0009057	macromolecule catabolic process	0.0364253721357344
GO:0022892	substrate-specific transporter activity	0.0381679905325293
GO:0005829	cytosol	0.0462239333408587
GO:0015758	glucose transport	0.0474632960498069
GO:0008645	hexose transport	0.0474632960498069
GO:0015749	monosaccharide transport	0.0474632960498069
GO:0007568	aging	0.0474632960498069

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>

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Cell Type

Ontology term	p-value	n

Uber Anatomy

Ontology term	p-value	n

Disease

Ontology term	p-value	n

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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