MCL coexpression mm9:1072

Phase1 CAGE Peaks

	Short description
Mm9::chr11:45669851..45669893,+	p@chr11:45669851..45669893 +
Mm9::chr14:75576396..75576412,+	p9@Lcp1
Mm9::chr17:24302011..24302034,-	p@chr17:24302011..24302034 -
Mm9::chr7:52358439..52358450,-	p@chr7:52358439..52358450 -
Mm9::chr7:52358454..52358468,-	p@chr7:52358454..52358468 -
Mm9::chr9:108028873..108028890,-	p@chr9:108028873..108028890 -
Mm9::chr9:62686574..62686623,+	p1@Cln6

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0042802	identical protein binding	0.00657390157114121
GO:0031987	locomotion during locomotory behavior	0.00657390157114121
GO:0001891	phagocytic cup	0.00657390157114121
GO:0045851	pH reduction	0.00657390157114121
GO:0051452	cellular pH reduction	0.00657390157114121
GO:0051453	regulation of cellular pH	0.00657390157114121
GO:0007042	lysosomal lumen acidification	0.00657390157114121
GO:0030641	cellular hydrogen ion homeostasis	0.00862777307470345
GO:0045862	positive regulation of proteolysis	0.0115024368688939
GO:0019864	IgG binding	0.0115024368688939
GO:0030004	cellular monovalent inorganic cation homeostasis	0.013143481366302
GO:0055067	monovalent inorganic cation homeostasis	0.013143481366302
GO:0001573	ganglioside metabolic process	0.013143481366302
GO:0005788	endoplasmic reticulum lumen	0.013143481366302
GO:0019865	immunoglobulin binding	0.0137998992205248
GO:0006687	glycosphingolipid metabolic process	0.0143741073271484
GO:0030162	regulation of proteolysis	0.0166073491042501
GO:0051017	actin filament bundle formation	0.0166073491042501
GO:0007040	lysosome organization and biogenesis	0.0174702955590397
GO:0042612	MHC class I protein complex	0.0174702955590397
GO:0006664	glycolipid metabolic process	0.0174702955590397
GO:0006885	regulation of pH	0.0174702955590397
GO:0006022	aminoglycan metabolic process	0.0174702955590397
GO:0030203	glycosaminoglycan metabolic process	0.0174702955590397
GO:0007033	vacuole organization and biogenesis	0.0174702955590397
GO:0006672	ceramide metabolic process	0.0195774227074295
GO:0005884	actin filament	0.0195774227074295
GO:0051015	actin filament binding	0.0196979418924547
GO:0046519	sphingoid metabolic process	0.0198100625757227
GO:0042611	MHC protein complex	0.0206794381373428
GO:0001726	ruffle	0.0251910804746685
GO:0007015	actin filament organization	0.0287009797667726
GO:0006665	sphingolipid metabolic process	0.0292196113910994
GO:0032403	protein complex binding	0.0330742153113077
GO:0019882	antigen processing and presentation	0.0373584336140453
GO:0006996	organelle organization and biogenesis	0.0396637116983314
GO:0008203	cholesterol metabolic process	0.0396637116983314
GO:0016125	sterol metabolic process	0.0417293940792968
GO:0051247	positive regulation of protein metabolic process	0.0417293940792968
GO:0031252	leading edge	0.0435394367539968
GO:0044432	endoplasmic reticulum part	0.0447033451764874

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>

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Cell Type

Ontology term	p-value	n

Uber Anatomy

Ontology term	p-value	n

Disease

Ontology term	p-value	n

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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