MCL coexpression mm9:1097

Phase1 CAGE Peaks

	Short description
Mm9::chr11:98769124..98769138,+	p2@Cdc6
Mm9::chr2:162880327..162880385,+	p2@Mybl2
Mm9::chr2:162880387..162880413,+	p1@Mybl2
Mm9::chr2:162880418..162880429,+	p4@Mybl2
Mm9::chr4:108252086..108252094,+	p2@Orc1
Mm9::chr7:38892471..38892504,-	p1@Ccne1
Mm9::chr7:38892509..38892528,-	p2@Ccne1

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0006260	DNA replication	0.000130837892876762
GO:0022402	cell cycle process	0.00408491639531306
GO:0006259	DNA metabolic process	0.00408491639531306
GO:0007049	cell cycle	0.0045787611389747
GO:0006139	nucleobase, nucleoside, nucleotide and nucleic acid metabolic process	0.0112369554901173
GO:0051301	cell division	0.0136759545366786
GO:0000307	cyclin-dependent protein kinase holoenzyme complex	0.0186178917305763
GO:0051726	regulation of cell cycle	0.0203336441198166
GO:0005634	nucleus	0.0203336441198166
GO:0043283	biopolymer metabolic process	0.0206797517638527
GO:0006270	DNA replication initiation	0.0220079684496529
GO:0017111	nucleoside-triphosphatase activity	0.0220079684496529
GO:0016462	pyrophosphatase activity	0.0220079684496529
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	0.0220079684496529
GO:0016817	hydrolase activity, acting on acid anhydrides	0.0220079684496529
GO:0016538	cyclin-dependent protein kinase regulator activity	0.024407879672774
GO:0043170	macromolecule metabolic process	0.0362424271274993
GO:0005819	spindle	0.0392044077488713
GO:0006261	DNA-dependent DNA replication	0.044930617520457
GO:0044238	primary metabolic process	0.0486474848363971
GO:0044237	cellular metabolic process	0.0486474848363971
GO:0043231	intracellular membrane-bound organelle	0.0486474848363971
GO:0043227	membrane-bound organelle	0.0486474848363971
GO:0019887	protein kinase regulator activity	0.0486474848363971

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>

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Cell Type

Ontology term	p-value	n

Uber Anatomy

Ontology term	p-value	n

Disease

Ontology term	p-value	n

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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