MCL coexpression mm9:1864

Phase1 CAGE Peaks

	Short description
Mm9::chr10:117147071..117147088,-	p2@Mdm2
Mm9::chr14:70167277..70167333,+	p1@Tnfrsf10b
Mm9::chr15:85690391..85690443,+	p3@Gtse1
Mm9::chr15:85690444..85690487,+	p4@Gtse1

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0045569	TRAIL binding	0.0118304296677352
GO:0043028	caspase regulator activity	0.0118304296677352
GO:0007089	traversing start control point of mitotic cell cycle	0.0118304296677352
GO:0008656	caspase activator activity	0.0118304296677352
GO:0002039	p53 binding	0.0118304296677352
GO:0051318	G1 phase	0.0118304296677352
GO:0000080	G1 phase of mitotic cell cycle	0.0118304296677352
GO:0016505	apoptotic protease activator activity	0.0118304296677352
GO:0016504	protease activator activity	0.0210249611337553
GO:0007346	regulation of progression through mitotic cell cycle	0.0315236175750344
GO:0016567	protein ubiquitination	0.0496531264424275
GO:0051325	interphase	0.0496531264424275
GO:0051329	interphase of mitotic cell cycle	0.0496531264424275

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>

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Uber Anatomy

Ontology term	p-value	n
peripheral nervous system	5.36e-07	11

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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