MCL coexpression mm9:2102

Phase1 CAGE Peaks

	Short description
Mm9::chr14:34791937..34791977,-	p1@Zfp488
Mm9::chr14:34791987..34791998,-	p2@Zfp488
Mm9::chr7:38554745..38554756,-	p7@Zfp536
Mm9::chr7:38554763..38554780,-	p1@Zfp536

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0048714	positive regulation of oligodendrocyte differentiation	0.00854560379022112
GO:0048713	regulation of oligodendrocyte differentiation	0.00854560379022112
GO:0014015	positive regulation of gliogenesis	0.00854560379022112
GO:0045687	positive regulation of glial cell differentiation	0.00854560379022112
GO:0014003	oligodendrocyte development	0.00854560379022112
GO:0045685	regulation of glial cell differentiation	0.00949381462173878
GO:0014013	regulation of gliogenesis	0.00949381462173878
GO:0048709	oligodendrocyte differentiation	0.00949381462173878
GO:0021782	glial cell development	0.00949381462173878
GO:0010001	glial cell differentiation	0.0318203804753961
GO:0042063	gliogenesis	0.0318203804753961
GO:0045597	positive regulation of cell differentiation	0.0327213510388878
GO:0051094	positive regulation of developmental process	0.0452779046561311

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

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Cell Type

Ontology term	p-value	n
neuron	1.12e-10	33
neuronal stem cell	1.12e-10	33
neuroblast	1.12e-10	33
electrically signaling cell	1.12e-10	33
autonomic neuron	5.37e-08	9
ectodermal cell	5.42e-08	44
neurectodermal cell	5.42e-08	44
neural cell	5.61e-08	43
electrically responsive cell	3.56e-07	39
electrically active cell	3.56e-07	39

Uber Anatomy

Ontology term	p-value	n
ectoderm-derived structure	1.08e-23	95
ectoderm	1.08e-23	95
presumptive ectoderm	1.08e-23	95
nervous system	3.21e-20	75
central nervous system	4.48e-20	73
neurectoderm	1.54e-19	64
neural plate	1.54e-19	64
presumptive neural plate	1.54e-19	64
ecto-epithelium	6.50e-18	73
pre-chordal neural plate	2.12e-13	49
structure with developmental contribution from neural crest	2.15e-13	92
regional part of nervous system	6.41e-13	54
neural tube	6.85e-12	52
neural rod	6.85e-12	52
future spinal cord	6.85e-12	52
neural keel	6.85e-12	52
brain	1.84e-09	47
future brain	1.84e-09	47
regional part of brain	5.20e-09	46
gray matter	7.36e-09	34
anterior neural tube	2.95e-08	40
autonomic nervous system	5.37e-08	9
regional part of forebrain	9.00e-08	39
forebrain	9.00e-08	39
future forebrain	9.00e-08	39
peripheral nervous system	1.46e-07	11
eye	2.32e-07	9
camera-type eye	2.32e-07	9
simple eye	2.32e-07	9
immature eye	2.32e-07	9
ocular region	2.32e-07	9
visual system	2.32e-07	9
face	2.32e-07	9
optic cup	2.32e-07	9
optic vesicle	2.32e-07	9
eye primordium	2.32e-07	9

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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