MCL coexpression mm9:984

Phase1 CAGE Peaks

	Short description
Mm9::chr1:74589455..74589492,+	p1@Plcd4
Mm9::chr3:107261813..107261838,-	p2@Kcnc4
Mm9::chr3:107261840..107261893,-	p1@Kcnc4
Mm9::chr3:107262609..107262634,-	p@chr3:107262609..107262634 -
Mm9::chr4:108829312..108829367,-	p2@Osbpl9
Mm9::chr6:113481495..113481506,-	p2@Tmem111
Mm9::chr7:31911778..31911791,-	p3@Scn1b
Mm9::chr7:31912183..31912196,-	p5@Scn1b

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0022832	voltage-gated channel activity	0.0212610862975629
GO:0005244	voltage-gated ion channel activity	0.0212610862975629
GO:0031420	alkali metal ion binding	0.0212610862975629
GO:0006810	transport	0.0212610862975629
GO:0051234	establishment of localization	0.0212610862975629
GO:0005261	cation channel activity	0.0212610862975629
GO:0051179	localization	0.0212610862975629
GO:0022836	gated channel activity	0.0212610862975629
GO:0046873	metal ion transmembrane transporter activity	0.0212610862975629
GO:0015672	monovalent inorganic cation transport	0.0212610862975629
GO:0007340	acrosome reaction	0.0212610862975629
GO:0004435	phosphoinositide phospholipase C activity	0.0212610862975629
GO:0004434	inositol or phosphatidylinositol phosphodiesterase activity	0.0212610862975629
GO:0005216	ion channel activity	0.0230202269040457
GO:0022838	substrate specific channel activity	0.0230202269040457
GO:0022803	passive transmembrane transporter activity	0.0230202269040457
GO:0015267	channel activity	0.0230202269040457
GO:0004629	phospholipase C activity	0.0230202269040457
GO:0030001	metal ion transport	0.0230774535726656
GO:0017156	calcium ion-dependent exocytosis	0.0275451680756006
GO:0008324	cation transmembrane transporter activity	0.0275451680756006
GO:0006812	cation transport	0.0275451680756006
GO:0005272	sodium channel activity	0.0311898189645894
GO:0015075	ion transmembrane transporter activity	0.0451749126702556
GO:0007338	single fertilization	0.0451749126702556
GO:0030384	phosphoinositide metabolic process	0.0458893449675082
GO:0004620	phospholipase activity	0.0458893449675082
GO:0006811	ion transport	0.0465019137658845
GO:0009566	fertilization	0.0465019137658845
GO:0022891	substrate-specific transmembrane transporter activity	0.0475471638115029
GO:0008076	voltage-gated potassium channel complex	0.0479144883263067
GO:0006650	glycerophospholipid metabolic process	0.0498336203933884

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>

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Uber Anatomy

Ontology term	p-value	n
ectoderm-derived structure	1.89e-17	95
ectoderm	1.89e-17	95
presumptive ectoderm	1.89e-17	95
ecto-epithelium	1.33e-16	73
regional part of nervous system	7.00e-16	54
neurectoderm	1.09e-14	64
neural plate	1.09e-14	64
presumptive neural plate	1.09e-14	64
neural tube	1.31e-14	52
neural rod	1.31e-14	52
future spinal cord	1.31e-14	52
neural keel	1.31e-14	52
central nervous system	3.94e-14	73
nervous system	6.86e-14	75
brain	2.94e-12	47
future brain	2.94e-12	47
structure with developmental contribution from neural crest	4.96e-12	92
regional part of brain	8.56e-12	46
pre-chordal neural plate	2.68e-10	49
gray matter	2.39e-09	34
anterior neural tube	3.59e-09	40
regional part of forebrain	1.36e-08	39
forebrain	1.36e-08	39
future forebrain	1.36e-08	39
brain grey matter	2.29e-07	29
regional part of telencephalon	2.29e-07	29
telencephalon	2.29e-07	29
occipital lobe	3.48e-07	10
visual cortex	3.48e-07	10
neocortex	3.48e-07	10
posterior neural tube	7.08e-07	12
chordal neural plate	7.08e-07	12

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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