Coexpression cluster:C95
From FANTOM5_SSTAR
Full id: C95_lung_aorta_trachea_penis_Alveolar_throat_endometrioid
Phase1 CAGE Peaks
Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data
No results for this coexpression
Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data
| GO ID | GO name | FDR corrected p-value |
|---|---|---|
| GO:0050828 | regulation of liquid surface tension | 3.30990684517979e-10 |
| GO:0007585 | respiratory gaseous exchange | 7.77735944715749e-07 |
| GO:0032501 | multicellular organismal process | 0.00156036647691286 |
| GO:0042592 | homeostatic process | 0.00156036647691286 |
| GO:0006817 | phosphate transport | 0.0100918815513624 |
| GO:0005578 | proteinaceous extracellular matrix | 0.0112064398878544 |
| GO:0005887 | integral to plasma membrane | 0.0112064398878544 |
| GO:0031226 | intrinsic to plasma membrane | 0.0112064398878544 |
| GO:0044421 | extracellular region part | 0.0126429836356155 |
| GO:0030324 | lung development | 0.0126429836356155 |
| GO:0065008 | regulation of biological quality | 0.0126429836356155 |
| GO:0030323 | respiratory tube development | 0.0126429836356155 |
| GO:0016712 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen | 0.0126429836356155 |
| GO:0048731 | system development | 0.0126429836356155 |
| GO:0007275 | multicellular organismal development | 0.0126429836356155 |
| GO:0006837 | serotonin transport | 0.0126429836356155 |
| GO:0043129 | surfactant homeostasis | 0.0126429836356155 |
| GO:0048875 | chemical homeostasis within a tissue | 0.0126429836356155 |
| GO:0017026 | procollagen C-endopeptidase activity | 0.0126429836356155 |
| GO:0015222 | serotonin transmembrane transporter activity | 0.0126429836356155 |
| GO:0018894 | dibenzo-p-dioxin metabolic process | 0.0126429836356155 |
| GO:0018904 | organic ether metabolic process | 0.0126429836356155 |
| GO:0015698 | inorganic anion transport | 0.0126429836356155 |
| GO:0048513 | organ development | 0.014878071801604 |
| GO:0006820 | anion transport | 0.0187250466571659 |
| GO:0042537 | benzene and derivative metabolic process | 0.0187250466571659 |
| GO:0005076 | receptor signaling protein serine/threonine kinase signaling protein activity | 0.0187250466571659 |
| GO:0021798 | forebrain dorsal/ventral pattern formation | 0.0187250466571659 |
| GO:0005335 | serotonin:sodium symporter activity | 0.0187250466571659 |
| GO:0030617 | transforming growth factor beta receptor, inhibitory cytoplasmic mediator activity | 0.0187250466571659 |
| GO:0005496 | steroid binding | 0.0202504632233741 |
| GO:0048856 | anatomical structure development | 0.0228120322311609 |
| GO:0009887 | organ morphogenesis | 0.0228120322311609 |
| GO:0048286 | alveolus development | 0.0233987298973967 |
| GO:0019834 | phospholipase A2 inhibitor activity | 0.0233987298973967 |
| GO:0045085 | negative regulation of interleukin-2 biosynthetic process | 0.0233987298973967 |
| GO:0048246 | macrophage chemotaxis | 0.0295467215956134 |
| GO:0021871 | forebrain regionalization | 0.0295467215956134 |
| GO:0035295 | tube development | 0.0301971429609436 |
| GO:0000267 | cell fraction | 0.0303220959468354 |
| GO:0015321 | sodium-dependent phosphate transmembrane transporter activity | 0.0323644717642325 |
| GO:0005072 | transforming growth factor beta receptor, cytoplasmic mediator activity | 0.0323644717642325 |
| GO:0008504 | monoamine transmembrane transporter activity | 0.0323644717642325 |
| GO:0044459 | plasma membrane part | 0.0323644717642325 |
| GO:0005071 | transmembrane receptor protein serine/threonine kinase signaling protein activity | 0.0365885426486297 |
| GO:0015844 | monoamine transport | 0.0365885426486297 |
| GO:0004115 | 3',5'-cyclic-AMP phosphodiesterase activity | 0.0400601955759071 |
| GO:0008533 | astacin activity | 0.0400601955759071 |
| GO:0030878 | thyroid gland development | 0.0400601955759071 |
| GO:0005615 | extracellular space | 0.0415304615064712 |
| GO:0032502 | developmental process | 0.0415304615064712 |
| GO:0001504 | neurotransmitter uptake | 0.0415304615064712 |
| GO:0042130 | negative regulation of T cell proliferation | 0.0415304615064712 |
| GO:0005890 | sodium:potassium-exchanging ATPase complex | 0.0415304615064712 |
| GO:0050766 | positive regulation of phagocytosis | 0.0450385551484781 |
| GO:0007492 | endoderm development | 0.0450385551484781 |
| GO:0016705 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen | 0.0462703829101813 |
| GO:0050764 | regulation of phagocytosis | 0.0466764296480633 |
| GO:0006833 | water transport | 0.0466764296480633 |
| GO:0050868 | negative regulation of T cell activation | 0.0466764296480633 |
| GO:0042044 | fluid transport | 0.0466764296480633 |
| GO:0005372 | water transporter activity | 0.0466764296480633 |
| GO:0001502 | cartilage condensation | 0.0466764296480633 |
| GO:0050672 | negative regulation of lymphocyte proliferation | 0.0466764296480633 |
| GO:0032945 | negative regulation of mononuclear cell proliferation | 0.0466764296480633 |
| GO:0008367 | bacterial binding | 0.0466764296480633 |
| GO:0016021 | integral to membrane | 0.0493105837232668 |
| GO:0005764 | lysosome | 0.0493105837232668 |
| GO:0000323 | lytic vacuole | 0.0493105837232668 |
| GO:0031224 | intrinsic to membrane | 0.0494672568566292 |
Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>
| Ontology term | p-value | n |
|---|
| Ontology term | p-value | n |
|---|
| Ontology term | p-value | n |
|---|
Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data
Novel motifs
JASPAR motifs
| Motifs | -log10(p-value) |
|---|---|
|
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ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data
No analysis results for this cluster
Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data
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