MCL coexpression mm9:1731

Phase1 CAGE Peaks

	Short description
Mm9::chr19:53526008..53526024,-	p2@5830416P10Rik
Mm9::chr7:109016961..109017012,-	p4@Folr1
Mm9::chr7:109017023..109017036,-	p15@Folr1
Mm9::chr7:109017526..109017537,-	p18@Folr1
Mm9::chr7:109017548..109017587,-	p11@Folr1

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0046655	folic acid metabolic process	0.00284884676491536
GO:0006620	posttranslational protein targeting to membrane	0.00379846235322048
GO:0008517	folic acid transporter activity	0.00379846235322048
GO:0051183	vitamin transporter activity	0.00447675920200985
GO:0051184	cofactor transporter activity	0.00447675920200985
GO:0005542	folic acid binding	0.00447675920200985
GO:0006760	folic acid and derivative metabolic process	0.00447675920200985
GO:0042558	pteridine and derivative metabolic process	0.00462937599298745
GO:0045047	protein targeting to ER	0.00601423205926575
GO:0006612	protein targeting to membrane	0.00769188626527147
GO:0006767	water-soluble vitamin metabolic process	0.0101004567119726
GO:0006752	group transfer coenzyme metabolic process	0.0128198104421191
GO:0006766	vitamin metabolic process	0.0134302776060295
GO:0046483	heterocycle metabolic process	0.0134302776060295
GO:0019842	vitamin binding	0.0197743481329419
GO:0006725	aromatic compound metabolic process	0.0197743481329419
GO:0048503	GPI anchor binding	0.0197743481329419
GO:0006732	coenzyme metabolic process	0.0242721744370788
GO:0035091	phosphoinositide binding	0.0242721744370788
GO:0045045	secretory pathway	0.0242721744370788
GO:0051186	cofactor metabolic process	0.0242721744370788
GO:0006605	protein targeting	0.0242721744370788
GO:0005543	phospholipid binding	0.0242721744370788
GO:0032940	secretion by cell	0.0242721744370788
GO:0032787	monocarboxylic acid metabolic process	0.0242721744370788
GO:0046903	secretion	0.0283788966197337
GO:0008289	lipid binding	0.0375625721596247
GO:0006886	intracellular protein transport	0.0391716430175862
GO:0005624	membrane fraction	0.0411704306671639
GO:0019752	carboxylic acid metabolic process	0.0411704306671639
GO:0006082	organic acid metabolic process	0.0411704306671639
GO:0000267	cell fraction	0.044157124856188
GO:0046907	intracellular transport	0.0490346958324825

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>

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Cell Type

Ontology term	p-value	n

Uber Anatomy

Ontology term	p-value	n

Disease

Ontology term	p-value	n

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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