MCL coexpression mm9:2403

Phase1 CAGE Peaks

	Short description
Mm9::chr4:41707334..41707363,+	p1@Il11ra1
Mm9::chr7:112885158..112885212,+	p1@Ilk
Mm9::chr7:30980039..30980050,-	p2@Capns1
Mm9::chr7:30980065..30980109,-	p1@Capns1

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0004921	interleukin-11 receptor activity	0.0190643145563095
GO:0019970	interleukin-11 binding	0.0190643145563095
GO:0001779	natural killer cell differentiation	0.0254163007270631
GO:0045197	establishment and/or maintenance of epithelial cell polarity	0.0333534115511529
GO:0035088	establishment and/or maintenance of apical/basal cell polarity	0.0381035655591249
GO:0030101	natural killer cell activation	0.0381035655591249
GO:0004198	calcium-dependent cysteine-type endopeptidase activity	0.0381035655591249
GO:0001658	ureteric bud branching	0.0428571151686477
GO:0007163	establishment and/or maintenance of cell polarity	0.0456691731015961
GO:0005925	focal adhesion	0.0456691731015961
GO:0005924	cell-substrate adherens junction	0.0456691731015961
GO:0001657	ureteric bud development	0.0456691731015961
GO:0004907	interleukin receptor activity	0.0456691731015961
GO:0030055	cell-matrix junction	0.0456691731015961
GO:0019965	interleukin binding	0.0456691731015961

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>

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Cell Type

Ontology term	p-value	n

Uber Anatomy

Ontology term	p-value	n

Disease

Ontology term	p-value	n

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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