MCL coexpression mm9:464

Phase1 CAGE Peaks

	Short description
Mm9::chr11:83222718..83222791,+	p2@Rasl10b
Mm9::chr13:96727565..96727567,-	p@chr13:96727565..96727567 -
Mm9::chr13:96902476..96902485,-	p5@Sv2c
Mm9::chr13:96902498..96902522,-	p2@Sv2c
Mm9::chr13:96902523..96902583,-	p1@Sv2c
Mm9::chr13:96902624..96902642,-	p3@Sv2c
Mm9::chr13:96902655..96902666,-	p4@Sv2c
Mm9::chr14:33274087..33274102,-	p1@Chat
Mm9::chr14:68701910..68701927,+	p1@Nefl
Mm9::chr1:136543278..136543288,+	p5@Syt2
Mm9::chr1:33964526..33964536,-	p5@Bend6
Mm9::chr4:119165152..119165166,-	p2@Rimkla
Mm9::chr5:125342609..125342620,-	p9@Ccdc92
Mm9::chr5:23929310..23929319,-	p3@Cdk5
Mm9::chr8:107995347..107995358,-	p3@Tppp3
Mm9::chr8:107995381..107995387,-	p5@Tppp3

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0008021	synaptic vesicle	0.00973174846942184
GO:0030136	clathrin-coated vesicle	0.00973174846942184
GO:0005057	receptor signaling protein activity	0.00973174846942184
GO:0030546	receptor activator activity	0.00973174846942184
GO:0030549	acetylcholine receptor activator activity	0.00973174846942184
GO:0014012	axon regeneration in the peripheral nervous system	0.00973174846942184
GO:0043125	ErbB-3 class receptor binding	0.00973174846942184
GO:0030135	coated vesicle	0.00973174846942184
GO:0005176	ErbB-2 class receptor binding	0.0153816653953618
GO:0005068	transmembrane receptor protein tyrosine kinase adaptor protein activity	0.0153816653953618
GO:0031133	regulation of axon diameter	0.0161440679945559
GO:0045110	intermediate filament bundle assembly	0.0161440679945559
GO:0014044	Schwann cell development	0.0161440679945559
GO:0007409	axonogenesis	0.0161440679945559
GO:0048667	neuron morphogenesis during differentiation	0.0161440679945559
GO:0048812	neurite morphogenesis	0.0161440679945559
GO:0030548	acetylcholine receptor regulator activity	0.0161440679945559
GO:0000904	cellular morphogenesis during differentiation	0.0161440679945559
GO:0016023	cytoplasmic membrane-bound vesicle	0.0161440679945559
GO:0007268	synaptic transmission	0.0161440679945559
GO:0031988	membrane-bound vesicle	0.0161440679945559
GO:0031103	axon regeneration	0.0161440679945559
GO:0031102	neurite regeneration	0.0161440679945559
GO:0031175	neurite development	0.0161440679945559
GO:0005883	neurofilament	0.0177383537688552
GO:0048678	response to axon injury	0.0177383537688552
GO:0048666	neuron development	0.0178843840841467
GO:0019226	transmission of nerve impulse	0.0183547129593702
GO:0014037	Schwann cell differentiation	0.0185513690271993
GO:0030545	receptor regulator activity	0.0189410615211977
GO:0005066	transmembrane receptor protein tyrosine kinase signaling protein activity	0.0189410615211977
GO:0060053	neurofilament cytoskeleton	0.0189410615211977
GO:0060052	neurofilament cytoskeleton organization and biogenesis	0.0189410615211977
GO:0008045	motor axon guidance	0.0189410615211977
GO:0045109	intermediate filament organization	0.0189410615211977
GO:0032990	cell part morphogenesis	0.0189410615211977
GO:0048858	cell projection morphogenesis	0.0189410615211977
GO:0030030	cell projection organization and biogenesis	0.0189410615211977
GO:0021782	glial cell development	0.0192384216766405
GO:0030182	neuron differentiation	0.0192384216766405
GO:0031099	regeneration	0.0192384216766405
GO:0042246	tissue regeneration	0.0192384216766405
GO:0043113	receptor clustering	0.0192384216766405
GO:0031410	cytoplasmic vesicle	0.0192384216766405
GO:0031982	vesicle	0.0196092906005297
GO:0050772	positive regulation of axonogenesis	0.0196092906005297
GO:0060078	regulation of postsynaptic membrane potential	0.0196092906005297
GO:0048699	generation of neurons	0.0199660593857038
GO:0030175	filopodium	0.0199660593857038
GO:0007172	signal complex assembly	0.0199660593857038
GO:0007267	cell-cell signaling	0.0207466497552354
GO:0007264	small GTPase mediated signal transduction	0.0213254175566963
GO:0022008	neurogenesis	0.0213254175566963
GO:0050769	positive regulation of neurogenesis	0.0213254175566963
GO:0045104	intermediate filament cytoskeleton organization and biogenesis	0.0235730400710741
GO:0042995	cell projection	0.0235730400710741
GO:0022607	cellular component assembly	0.0240352414148993
GO:0030054	cell junction	0.0247094857841336
GO:0005544	calcium-dependent phospholipid binding	0.0247094857841336
GO:0045103	intermediate filament-based process	0.0255729826199389
GO:0007422	peripheral nervous system development	0.0284485638868522
GO:0043524	negative regulation of neuron apoptosis	0.0284485638868522
GO:0043112	receptor metabolic process	0.0304231868708594
GO:0000902	cell morphogenesis	0.0319966118086197
GO:0032989	cellular structure morphogenesis	0.0319966118086197
GO:0050770	regulation of axonogenesis	0.034304754781197
GO:0004693	cyclin-dependent protein kinase activity	0.034304754781197
GO:0050885	neuromuscular process controlling balance	0.0360437513677712
GO:0043523	regulation of neuron apoptosis	0.037731129007329
GO:0005622	intracellular	0.0393759908222754
GO:0051402	neuron apoptosis	0.0403908683748798
GO:0010001	glial cell differentiation	0.0403908683748798
GO:0050877	neurological system process	0.0411317890707139
GO:0043623	cellular protein complex assembly	0.0413562758033976
GO:0042063	gliogenesis	0.0418192535023569
GO:0042391	regulation of membrane potential	0.0422697727458422
GO:0060090	molecular adaptor activity	0.0436955521739576
GO:0050767	regulation of neurogenesis	0.0441096615291231
GO:0050905	neuromuscular process	0.044575348617974
GO:0006836	neurotransmitter transport	0.044575348617974
GO:0048589	developmental growth	0.044575348617974
GO:0007399	nervous system development	0.044575348617974
GO:0003008	system process	0.044575348617974
GO:0030027	lamellipodium	0.044575348617974
GO:0030334	regulation of cell migration	0.046728730596565

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>

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Cell Type

Ontology term	p-value	n

Uber Anatomy

Ontology term	p-value	n

Disease

Ontology term	p-value	n

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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