MCL coexpression mm9:2529

Phase1 CAGE Peaks

	Short description
Mm9::chr10:127496003..127496016,+	p5@Gm9769 p5@LOC100048119 p5@Ptges3
Mm9::chr6:34659575..34659586,+	p12@Cald1
Mm9::chr6:34659610..34659635,+	p3@Cald1

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0030478	actin cap	0.00191749301484687
GO:0030864	cortical actin cytoskeleton	0.00814934531309922
GO:0006940	regulation of smooth muscle contraction	0.00814934531309922
GO:0030863	cortical cytoskeleton	0.00814934531309922
GO:0006939	smooth muscle contraction	0.00894830073595209
GO:0044448	cell cortex part	0.00894830073595209
GO:0006937	regulation of muscle contraction	0.00903960992713526
GO:0005938	cell cortex	0.0112652714622254
GO:0003012	muscle system process	0.0159151920232291
GO:0006936	muscle contraction	0.0159151920232291
GO:0015629	actin cytoskeleton	0.0331203338928097
GO:0003779	actin binding	0.0386694424660787
GO:0051239	regulation of multicellular organismal process	0.041004850625187
GO:0008092	cytoskeletal protein binding	0.0457459047827755

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>

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Cell Type

Ontology term	p-value	n

Uber Anatomy

Ontology term	p-value	n

Disease

Ontology term	p-value	n

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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