MCL coexpression mm9:635

Phase1 CAGE Peaks

	Short description
Mm9::chr10:127774817..127774874,+	p1@Cs
Mm9::chr11:6191663..6191690,+	p2@Ogdh
Mm9::chr4:116230385..116230404,+	p5@Gpbp1l1
Mm9::chr5:136254498..136254515,+	p3@Mdh2
Mm9::chr5:136254517..136254533,+	p1@Mdh2
Mm9::chr5:136254544..136254559,+	p2@Mdh2
Mm9::chr5:136254570..136254582,+	p4@Mdh2
Mm9::chr7:104727938..104728011,-	p1@1810020D17Rik
Mm9::chr8:42101937..42101968,-	p5@Mtus1
Mm9::chr9:108839183..108839195,-	p@chr9:108839183..108839195 -
Mm9::chr9:108839202..108839231,-	p@chr9:108839202..108839231 -

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0006096	glycolysis	0.000719686101583094
GO:0006007	glucose catabolic process	0.000719686101583094
GO:0046365	monosaccharide catabolic process	0.000719686101583094
GO:0019320	hexose catabolic process	0.000719686101583094
GO:0046164	alcohol catabolic process	0.000719686101583094
GO:0044275	cellular carbohydrate catabolic process	0.000835044202329801
GO:0016052	carbohydrate catabolic process	0.000852708932219754
GO:0006006	glucose metabolic process	0.00135788563649404
GO:0005739	mitochondrion	0.0017805292280721
GO:0019318	hexose metabolic process	0.0017805292280721
GO:0005996	monosaccharide metabolic process	0.0017805292280721
GO:0050164	oxoglutarate dehydrogenase (NADP+) activity	0.0017805292280721
GO:0004591	oxoglutarate dehydrogenase (succinyl-transferring) activity	0.00305216858660128
GO:0004691	cAMP-dependent protein kinase activity	0.00305216858660128
GO:0044265	cellular macromolecule catabolic process	0.00377011932676117
GO:0030976	thiamin pyrophosphate binding	0.00377011932676117
GO:0030060	L-malate dehydrogenase activity	0.00377011932676117
GO:0044262	cellular carbohydrate metabolic process	0.0039228738921035
GO:0006066	alcohol metabolic process	0.0039228738921035
GO:0004690	cyclic nucleotide-dependent protein kinase activity	0.0042725677946356
GO:0009057	macromolecule catabolic process	0.00468653004588212
GO:0006108	malate metabolic process	0.00485492465245523
GO:0005975	carbohydrate metabolic process	0.00603378529492736
GO:0016624	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor	0.00622980388168085
GO:0016615	malate dehydrogenase activity	0.00683461031047704
GO:0044248	cellular catabolic process	0.00711899562963582
GO:0043648	dicarboxylic acid metabolic process	0.00711899562963582
GO:0031594	neuromuscular junction	0.00991357063876156
GO:0009056	catabolic process	0.0106749828994384
GO:0006100	tricarboxylic acid cycle intermediate metabolic process	0.0106749828994384
GO:0051969	regulation of transmission of nerve impulse	0.0133400725415185
GO:0050804	regulation of synaptic transmission	0.0133400725415185
GO:0006099	tricarboxylic acid cycle	0.0145990669148224
GO:0046356	acetyl-CoA catabolic process	0.0145990669148224
GO:0001707	mesoderm formation	0.0145990669148224
GO:0048332	mesoderm morphogenesis	0.0145990669148224
GO:0031644	regulation of neurological process	0.0145990669148224
GO:0009060	aerobic respiration	0.0145990669148224
GO:0001704	formation of primary germ layer	0.0147303354289522
GO:0044444	cytoplasmic part	0.0147303354289522
GO:0009109	coenzyme catabolic process	0.0147303354289522
GO:0016620	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	0.0147303354289522
GO:0045333	cellular respiration	0.0148060594833286
GO:0016491	oxidoreductase activity	0.0148060594833286
GO:0051187	cofactor catabolic process	0.0151680576498623
GO:0006084	acetyl-CoA metabolic process	0.0157639835889618
GO:0016903	oxidoreductase activity, acting on the aldehyde or oxo group of donors	0.0172399256059361
GO:0007498	mesoderm development	0.0217541713803542
GO:0007369	gastrulation	0.0269447198396174
GO:0015980	energy derivation by oxidation of organic compounds	0.0281032602653716
GO:0048729	tissue morphogenesis	0.0312938817120633
GO:0019842	vitamin binding	0.0428982228502034
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	0.0440809510405541
GO:0050662	coenzyme binding	0.0456094997535444
GO:0016614	oxidoreductase activity, acting on CH-OH group of donors	0.0459307794156284

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>

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Cell Type

Ontology term	p-value	n

Uber Anatomy

Ontology term	p-value	n

Disease

Ontology term	p-value	n

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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