MCL coexpression mm9:465

Phase1 CAGE Peaks

	Short description
Mm9::chr12:105228129..105228156,-	p2@Serpina11
Mm9::chr12:105228160..105228182,-	p1@Serpina11
Mm9::chr15:102007749..102007752,+	p@chr15:102007749..102007752 +
Mm9::chr15:102019365..102019382,-	p5@Csad
Mm9::chr15:102019414..102019427,-	p6@Csad
Mm9::chr15:102019436..102019461,-	p3@Csad
Mm9::chr15:102019463..102019481,-	p2@Csad
Mm9::chr18:20832196..20832271,-	p@chr18:20832196..20832271 -
Mm9::chr18:65380476..65380484,-	p@chr18:65380476..65380484 -
Mm9::chr1:174825179..174825194,-	p2@Apcs
Mm9::chr2:157643694..157643719,+	p@chr2:157643694..157643719 +
Mm9::chr3:82835369..82835408,-	p@chr3:82835369..82835408 -
Mm9::chr3:82847241..82847271,+	p@chr3:82847241..82847271 +
Mm9::chr3:82847323..82847360,+	p@chr3:82847323..82847360 +
Mm9::chr3:82847793..82847801,+	p@chr3:82847793..82847801 +
Mm9::chr9:103123231..103123264,+	p@chr9:103123231..103123264 +

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0004782	sulfinoalanine decarboxylase activity	0.0025199956022708
GO:0046439	L-cysteine metabolic process	0.0025199956022708
GO:0019448	L-cysteine catabolic process	0.0025199956022708
GO:0019452	L-cysteine catabolic process to taurine	0.0025199956022708
GO:0009093	cysteine catabolic process	0.0025199956022708
GO:0019530	taurine metabolic process	0.0025199956022708
GO:0044273	sulfur compound catabolic process	0.00283483972454542
GO:0000098	sulfur amino acid catabolic process	0.00283483972454542
GO:0006534	cysteine metabolic process	0.00419930234896127
GO:0009071	serine family amino acid catabolic process	0.00604600142849892
GO:0000096	sulfur amino acid metabolic process	0.0107011816398053
GO:0009069	serine family amino acid metabolic process	0.0107011816398053
GO:0016831	carboxy-lyase activity	0.0151000999805382
GO:0016830	carbon-carbon lyase activity	0.0204795160219966
GO:0009063	amino acid catabolic process	0.021682605905944
GO:0030170	pyridoxal phosphate binding	0.021682605905944
GO:0009310	amine catabolic process	0.0234504393678624
GO:0044270	nitrogen compound catabolic process	0.0234504393678624
GO:0006790	sulfur metabolic process	0.0237978560598355
GO:0006575	amino acid derivative metabolic process	0.0327330241633306
GO:0004867	serine-type endopeptidase inhibitor activity	0.0358785136565338
GO:0019842	vitamin binding	0.0358785136565338
GO:0004866	endopeptidase inhibitor activity	0.0455879901011233
GO:0030414	protease inhibitor activity	0.0455879901011233
GO:0016829	lyase activity	0.0455879901011233
GO:0048037	cofactor binding	0.0484061985406142

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>

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Uber Anatomy

Ontology term	p-value	n
liver	2.49e-23	22
epithelial sac	2.49e-23	22
digestive gland	2.49e-23	22
epithelium of foregut-midgut junction	2.49e-23	22
anatomical boundary	2.49e-23	22
hepatobiliary system	2.49e-23	22
foregut-midgut junction	2.49e-23	22
hepatic diverticulum	2.49e-23	22
liver primordium	2.49e-23	22
septum transversum	2.49e-23	22
liver bud	2.49e-23	22
digestive tract diverticulum	5.72e-22	23
sac	5.72e-22	23
exocrine gland	1.39e-19	25
exocrine system	1.39e-19	25
abdomen element	3.25e-17	49
abdominal segment element	3.25e-17	49
abdominal segment of trunk	3.25e-17	49
abdomen	3.25e-17	49
trunk mesenchyme	3.46e-13	45
mesenchyme	8.42e-12	61
entire embryonic mesenchyme	8.42e-12	61
subdivision of trunk	3.63e-10	66
trunk region element	8.95e-09	79
epithelial tube	8.91e-08	47
endocrine gland	3.37e-07	60

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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