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MCL coexpression mm9:718

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Phase1 CAGE Peaks

 Short description
Mm9::chr11:98219716..98219771,+p1@Stard3
Mm9::chr13:24893063..24893082,+p1@BC005537
Mm9::chr15:76181104..76181175,-p2@Sharpin
Mm9::chr17:34056590..34056621,+p1@Tapbp
Mm9::chr17:34056624..34056635,+p2@Tapbp
Mm9::chr17:35400032..35400045,+p1@H2-D1
Mm9::chr5:34868446..34868518,+p1@Sh3bp2
Mm9::chr7:20408047..20408125,-p1@Bcl3
Mm9::chr7:51809271..51809325,-p1@Nr1h2
Mm9::chr7:86993077..86993110,-p2@Anpep


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


GO IDGO nameFDR corrected p-value
GO:0002474antigen processing and presentation of peptide antigen via MHC class I0.00724505164829319
GO:0048002antigen processing and presentation of peptide antigen0.00924049014773828
GO:0019882antigen processing and presentation0.00924049014773828
GO:0050823peptide antigen stabilization0.00924049014773828
GO:0045082positive regulation of interleukin-10 biosynthetic process0.00924049014773828
GO:0002312B cell activation during immune response0.00924049014773828
GO:0045074regulation of interleukin-10 biosynthetic process0.00924049014773828
GO:0002315marginal zone B cell differentiation0.00924049014773828
GO:0042536negative regulation of tumor necrosis factor biosynthetic process0.00924049014773828
GO:0002313mature B cell differentiation during immune response0.00924049014773828
GO:0042091interleukin-10 biosynthetic process0.00924049014773828
GO:0050822peptide stabilization0.00924049014773828
GO:0002266follicular dendritic cell activation0.0138580772896944
GO:0002268follicular dendritic cell differentiation0.0138580772896944
GO:0042832defense response to protozoan0.0138580772896944
GO:0002335mature B cell differentiation0.0138580772896944
GO:0001562response to protozoan0.0195605928569083
GO:0045064T-helper 2 cell differentiation0.0211089724546047
GO:0019883antigen processing and presentation of endogenous antigen0.0211089724546047
GO:0002483antigen processing and presentation of endogenous peptide antigen0.0211089724546047
GO:0019885antigen processing and presentation of endogenous peptide antigen via MHC class I0.0211089724546047
GO:0032613interleukin-10 production0.0221431809126398
GO:0019730antimicrobial humoral response0.0221431809126398
GO:0042534regulation of tumor necrosis factor biosynthetic process0.0221431809126398
GO:0042092T-helper 2 type immune response0.0221431809126398
GO:0042533tumor necrosis factor biosynthetic process0.0221431809126398
GO:0002376immune system process0.0221431809126398
GO:0002467germinal center formation0.0221431809126398
GO:0017127cholesterol transporter activity0.0221431809126398
GO:0032729positive regulation of interferon-gamma production0.0221431809126398
GO:0015248sterol transporter activity0.0221431809126398
GO:0048536spleen development0.0221431809126398
GO:0002294CD4-positive, alpha-beta T cell differentiation during immune response0.0221431809126398
GO:0002292T cell differentiation during immune response0.0221431809126398
GO:0042093T-helper cell differentiation0.0221431809126398
GO:0002285lymphocyte activation during immune response0.0221431809126398
GO:0015485cholesterol binding0.0221431809126398
GO:0042088T-helper 1 type immune response0.0221431809126398
GO:0002293alpha-beta T cell differentiation during immune response0.0221431809126398
GO:0002286T cell activation during immune response0.0221431809126398
GO:0006518peptide metabolic process0.0221431809126398
GO:0002366leukocyte activation during immune response0.0221431809126398
GO:0042771DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis0.0221431809126398
GO:0032649regulation of interferon-gamma production0.0221431809126398
GO:0002263cell activation during immune response0.0221431809126398
GO:0042036negative regulation of cytokine biosynthetic process0.0240640605136774
GO:0004179membrane alanyl aminopeptidase activity0.0248450617340259
GO:0043367CD4-positive, alpha beta T cell differentiation0.0248450617340259
GO:0016284alanine aminopeptidase activity0.0248450617340259
GO:0030330DNA damage response, signal transduction by p53 class mediator0.028764067195156
GO:0032934sterol binding0.0297795669440622
GO:0006700C21-steroid hormone biosynthetic process0.0297795669440622
GO:0032640tumor necrosis factor production0.0312986652257444
GO:0032609interferon-gamma production0.0321650672965152
GO:0042612MHC class I protein complex0.0321650672965152
GO:0008630DNA damage response, signal transduction resulting in induction of apoptosis0.0329699268078963
GO:0008207C21-steroid hormone metabolic process0.0329699268078963
GO:0001819positive regulation of cytokine production0.0380974731358029
GO:0046632alpha-beta T cell differentiation0.0393168040238089
GO:0017148negative regulation of translation0.0459903513050557
GO:0031327negative regulation of cellular biosynthetic process0.0470368520117554
GO:0042611MHC protein complex0.0472862331522246
GO:0005770late endosome0.0472862331522246



Relative expression of the co-expression cluster over median <br>Analyst:





Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>


Cell Type
Ontology termp-valuen
motile cell1.44e-0954
connective tissue cell2.12e-0946
mesenchymal cell2.12e-0946

Uber Anatomy
Ontology termp-valuen
endoderm-derived structure3.82e-15118
endoderm3.82e-15118
presumptive endoderm3.82e-15118
digestive system1.66e-14116
digestive tract1.66e-14116
primitive gut1.66e-14116
subdivision of digestive tract1.83e-13114
hemolymphoid system1.11e-1148
immune system1.11e-1148
hematopoietic system4.82e-1045
blood island4.82e-1045
connective tissue2.12e-0946
organ component layer2.75e-0924
unilaminar epithelium8.16e-0966
intestine2.22e-0831
mucosa2.61e-0815
gut epithelium3.28e-0855
endo-epithelium1.78e-0769
gastrointestinal system1.81e-0747
bone marrow3.60e-0716
intestinal mucosa4.14e-0713
anatomical wall4.14e-0713
wall of intestine4.14e-0713
gastrointestinal system mucosa4.14e-0713
musculoskeletal system9.52e-0732


TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs




JASPAR motifs


Motifs-log10(p-value)

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