MCL coexpression mm9:1302

Phase1 CAGE Peaks

	Short description
Mm9::chr11:7097835..7097842,+	p4@Igfbp1
Mm9::chr12:85393064..85393095,+	p1@Acot3
Mm9::chr12:85393125..85393134,+	p3@Acot3
Mm9::chr19:38446996..38447010,-	p@chr19:38446996..38447010 -
Mm9::chr4:115236284..115236304,+	p1@Cyp4a31
Mm9::chr8:62994811..62994838,+	p@chr8:62994811..62994838 +

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0032788	saturated monocarboxylic acid metabolic process	0.00986085235671182
GO:0032789	unsaturated monocarboxylic acid metabolic process	0.00986085235671182
GO:0000038	very-long-chain fatty acid metabolic process	0.0197065807078767
GO:0016290	palmitoyl-CoA hydrolase activity	0.0197065807078767
GO:0006637	acyl-CoA metabolic process	0.0197065807078767
GO:0016291	acyl-CoA thioesterase activity	0.0197065807078767
GO:0001676	long-chain fatty acid metabolic process	0.0197065807078767
GO:0016289	CoA hydrolase activity	0.0197065807078767
GO:0005520	insulin-like growth factor binding	0.0229847113442384
GO:0019838	growth factor binding	0.0481938565964769

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>

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Uber Anatomy

Ontology term	p-value	n
abdomen element	5.79e-22	49
abdominal segment element	5.79e-22	49
abdominal segment of trunk	5.79e-22	49
abdomen	5.79e-22	49
liver	1.36e-18	22
epithelial sac	1.36e-18	22
digestive gland	1.36e-18	22
epithelium of foregut-midgut junction	1.36e-18	22
anatomical boundary	1.36e-18	22
hepatobiliary system	1.36e-18	22
foregut-midgut junction	1.36e-18	22
hepatic diverticulum	1.36e-18	22
liver primordium	1.36e-18	22
septum transversum	1.36e-18	22
liver bud	1.36e-18	22
digestive tract diverticulum	1.36e-17	23
sac	1.36e-17	23
mesenchyme	3.70e-16	61
entire embryonic mesenchyme	3.70e-16	61
exocrine gland	7.85e-16	25
exocrine system	7.85e-16	25
subdivision of trunk	2.26e-14	66
kidney	3.01e-12	14
kidney mesenchyme	3.01e-12	14
upper urinary tract	3.01e-12	14
kidney rudiment	3.01e-12	14
kidney field	3.01e-12	14
trunk region element	8.19e-11	79
urinary system structure	5.39e-09	18
trunk mesenchyme	5.73e-09	45
trunk	1.24e-08	90
renal system	2.12e-08	19
epithelial tube	2.10e-07	47
cavitated compound organ	2.22e-07	21

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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