MCL coexpression mm9:457

Phase1 CAGE Peaks

	Short description
Mm9::chr10:88202891..88202898,+	p@chr10:88202891..88202898 +
Mm9::chr10:89055671..89055697,-	p@chr10:89055671..89055697 -
Mm9::chr11:101797987..101797999,+	p@chr11:101797987..101797999 +
Mm9::chr15:74647718..74647727,-	p2@Gml
Mm9::chr16:57199200..57199210,-	p@chr16:57199200..57199210 -
Mm9::chr17:24112500..24112507,-	p3@Prss30
Mm9::chr17:24835294..24835316,+	p4@Noxo1
Mm9::chr17:31579883..31579898,+	p5@Pde9a
Mm9::chr18:15561204..15561233,-	p4@Aqp4
Mm9::chr5:29550488..29550489,+	p@chr5:29550488..29550489 +
Mm9::chr6:134193540..134193545,-	p1@ENSMUST00000171098
Mm9::chrX:130646305..130646327,-	p1@Nox1
Mm9::chrX:130646345..130646353,-	p4@Nox1
Mm9::chrX:130646365..130646375,-	p3@Nox1
Mm9::chrX:130646391..130646412,-	p2@Nox1
Mm9::chrX:136330909..136330938,-	p@chrX:136330909..136330938 -

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0006801	superoxide metabolic process	0.000219149897867761
GO:0006800	oxygen and reactive oxygen species metabolic process	0.000423256398957932
GO:0016176	superoxide-generating NADPH oxidase activator activity	0.00847140396894049
GO:0042554	superoxide release	0.00847140396894049
GO:0050664	oxidoreductase activity, acting on NADH or NADPH, with oxygen as acceptor	0.00847140396894049
GO:0016175	superoxide-generating NADPH oxidase activity	0.00847140396894049
GO:0030104	water homeostasis	0.010745982262163
GO:0047555	3',5'-cyclic-GMP phosphodiesterase activity	0.010745982262163
GO:0018987	osmoregulation	0.010745982262163
GO:0015250	water channel activity	0.010745982262163
GO:0005372	water transporter activity	0.010745982262163
GO:0006833	water transport	0.010745982262163
GO:0042044	fluid transport	0.010745982262163
GO:0004114	3',5'-cyclic-nucleotide phosphodiesterase activity	0.021747829321369
GO:0004112	cyclic-nucleotide phosphodiesterase activity	0.0219858569324737
GO:0008081	phosphoric diester hydrolase activity	0.0490826525886069
GO:0016651	oxidoreductase activity, acting on NADH or NADPH	0.0490826525886069
GO:0050878	regulation of body fluid levels	0.0491491133962644

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

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Cell Type

Ontology term	p-value	n
transporting cell	6.93e-14	3
M cell of gut	6.93e-14	3
brush border epithelial cell	1.77e-11	6
gut absorptive cell	1.77e-11	6
absorptive cell	1.77e-11	6
enterocyte	1.77e-11	6
intestinal epithelial cell	2.09e-11	9
epithelial cell of alimentary canal	2.09e-11	9
columnar/cuboidal epithelial cell	7.42e-10	7
epithelial cell	8.26e-10	25
endo-epithelial cell	9.44e-07	15

Uber Anatomy

Ontology term	p-value	n
intestine	1.24e-26	31
mucosa	3.22e-26	15
intestinal mucosa	2.43e-19	13
anatomical wall	2.43e-19	13
wall of intestine	2.43e-19	13
gastrointestinal system mucosa	2.43e-19	13
gastrointestinal system	3.32e-19	47
small intestine	2.73e-16	4
organ component layer	8.52e-16	24
ileal mucosa	5.62e-13	3
ileum	5.62e-13	3
mucosa of small intestine	5.62e-13	3
wall of small intestine	5.62e-13	3
epithelium of mucosa	2.09e-11	9
gastrointestinal system epithelium	2.09e-11	9
intestinal epithelium	2.09e-11	9
gut-associated lymphoid tissue	1.52e-09	2
mucosa-associated lymphoid tissue	1.52e-09	2
lymphoid tissue	1.52e-09	2
simple columnar epithelium	2.71e-09	11
colon	5.67e-09	2
large intestine	5.67e-09	2
digestive system	2.66e-08	116
digestive tract	2.66e-08	116
primitive gut	2.66e-08	116
endoderm-derived structure	4.16e-08	118
endoderm	4.16e-08	118
presumptive endoderm	4.16e-08	118

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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