MCL coexpression mm9:614

Phase1 CAGE Peaks

	Short description
Mm9::chr12:66137306..66137345,+	p1@Prpf39
Mm9::chr15:6658372..6658396,+	p1@Rictor
Mm9::chr18:84758883..84758919,-	p1@Zfp407
Mm9::chr19:3575708..3575756,-	p1@Ppp6r3
Mm9::chr1:129765361..129765384,+	p1@Rab3gap1
Mm9::chr2:119722948..119723028,+	p1@Mga
Mm9::chr2:180436702..180436751,-	p1@Dido1
Mm9::chr2:53050248..53050294,-	p1@Prpf40a
Mm9::chr2:59963708..59963832,-	p1@Baz2b
Mm9::chr5:33196834..33196897,-	p1@C330019G07Rik
Mm9::chr7:117205217..117205246,+	p1@Zfp143
Mm9::chrX:39265054..39265089,-	p1@Thoc2

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0006359	regulation of transcription from RNA polymerase III promoter	0.013477236618638
GO:0003709	RNA polymerase III transcription factor activity	0.013477236618638
GO:0031932	TORC 2 complex	0.013477236618638
GO:0006383	transcription from RNA polymerase III promoter	0.0303104929307956
GO:0051896	regulation of protein kinase B signaling cascade	0.0372893614573972
GO:0003704	specific RNA polymerase II transcription factor activity	0.0372893614573972
GO:0008380	RNA splicing	0.0372893614573972
GO:0006397	mRNA processing	0.0493083604530968
GO:0043491	protein kinase B signaling cascade	0.0493083604530968

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

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Cell Type

Ontology term	p-value	n
lymphocyte	4.03e-07	13
common lymphoid progenitor	4.03e-07	13
lymphoid lineage restricted progenitor cell	4.69e-07	12

Uber Anatomy

Ontology term	p-value	n
primordium	1.49e-09	134
respiratory system	4.34e-09	42
anterior region of body	6.05e-09	43
respiratory tract	9.27e-09	41
craniocervical region	4.82e-08	36
hemopoietic organ	7.37e-08	29
immune organ	7.37e-08	29
mixed endoderm/mesoderm-derived structure	1.16e-07	35
gland of gut	5.22e-07	24
organism subdivision	9.79e-07	150

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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