MCL coexpression mm9:2045

Phase1 CAGE Peaks

	Short description
Mm9::chr12:77938456..77938467,+	p2@Fntb
Mm9::chr3:31048856..31048880,+	p1@Cldn11
Mm9::chr3:31048886..31048901,+	p2@Cldn11
Mm9::chr3:31062299..31062310,+	p@chr3:31062299..31062310 +

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0004660	protein farnesyltransferase activity	0.0117437619403576
GO:0004311	farnesyltranstransferase activity	0.0117437619403576
GO:0048146	positive regulation of fibroblast proliferation	0.0117437619403576
GO:0048144	fibroblast proliferation	0.0117437619403576
GO:0048145	regulation of fibroblast proliferation	0.0117437619403576
GO:0008318	protein prenyltransferase activity	0.014678093558699
GO:0004659	prenyltransferase activity	0.0188687317610276
GO:0007272	ensheathment of neurons	0.0236370233541989
GO:0008366	axon ensheathment	0.0236370233541989
GO:0001508	regulation of action potential	0.0271358705618195
GO:0016765	transferase activity, transferring alkyl or aryl (other than methyl) groups	0.0346556479246996
GO:0005923	tight junction	0.0427430645566547
GO:0042060	wound healing	0.0439401619713391
GO:0043296	apical junction complex	0.0439401619713391
GO:0016327	apicolateral plasma membrane	0.0439401619713391

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>

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Uber Anatomy

Ontology term	p-value	n
ectoderm-derived structure	3.07e-20	95
ectoderm	3.07e-20	95
presumptive ectoderm	3.07e-20	95
nervous system	5.89e-20	75
central nervous system	7.87e-20	73
structure with developmental contribution from neural crest	4.53e-19	92
neurectoderm	1.02e-18	64
neural plate	1.02e-18	64
presumptive neural plate	1.02e-18	64
regional part of nervous system	3.79e-18	54
ecto-epithelium	2.60e-17	73
neural tube	5.91e-17	52
neural rod	5.91e-17	52
future spinal cord	5.91e-17	52
neural keel	5.91e-17	52
brain	2.34e-14	47
future brain	2.34e-14	47
regional part of brain	7.02e-14	46
pre-chordal neural plate	1.68e-13	49
anterior neural tube	2.33e-11	40
regional part of forebrain	7.24e-11	39
forebrain	7.24e-11	39
future forebrain	7.24e-11	39
gray matter	1.79e-08	34

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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