MCL coexpression mm9:2203

Phase1 CAGE Peaks

	Short description
Mm9::chr17:31433667..31433739,+	p2@Slc37a1
Mm9::chr17:31433741..31433761,+	p3@Slc37a1
Mm9::chr5:93238358..93238397,+	p2@Shroom3
Mm9::chr5:93238398..93238462,+	p1@Shroom3

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

---

GO ID	GO name	FDR corrected p-value
GO:0015665	alcohol transmembrane transporter activity	0.00164356544129732
GO:0015794	glycerol-3-phosphate transport	0.00164356544129732
GO:0015793	glycerol transport	0.00164356544129732
GO:0015169	glycerol-3-phosphate transmembrane transporter activity	0.00164356544129732
GO:0015168	glycerol transmembrane transporter activity	0.00164356544129732
GO:0015166	polyol transmembrane transporter activity	0.00164356544129732
GO:0006127	glycerophosphate shuttle	0.00164356544129732
GO:0002065	columnar/cuboidal epithelial cell differentiation	0.00230092858385784
GO:0015791	polyol transport	0.00230092858385784
GO:0002066	columnar/cuboidal epithelial cell development	0.00230092858385784
GO:0006072	glycerol-3-phosphate metabolic process	0.00627457213097509
GO:0002064	epithelial cell development	0.00671012245769187
GO:0006071	glycerol metabolic process	0.0164270998043318
GO:0019751	polyol metabolic process	0.0164270998043318
GO:0030855	epithelial cell differentiation	0.0233848781821928
GO:0005351	sugar:hydrogen ion symporter activity	0.0233848781821928
GO:0051119	sugar transmembrane transporter activity	0.0233848781821928
GO:0015144	carbohydrate transmembrane transporter activity	0.0233848781821928
GO:0001843	neural tube closure	0.0233848781821928
GO:0014020	primary neural tube formation	0.0233848781821928
GO:0022603	regulation of anatomical structure morphogenesis	0.0233848781821928
GO:0008360	regulation of cell shape	0.0233848781821928
GO:0022604	regulation of cell morphogenesis	0.0233848781821928
GO:0016324	apical plasma membrane	0.0233848781821928
GO:0001841	neural tube formation	0.0233848781821928
GO:0001839	neural plate morphogenesis	0.0233848781821928
GO:0001840	neural plate development	0.0233848781821928
GO:0001838	embryonic epithelial tube formation	0.0233848781821928
GO:0005912	adherens junction	0.0237371809789831
GO:0008643	carbohydrate transport	0.0237371809789831
GO:0021915	neural tube development	0.0240810054663014
GO:0016331	morphogenesis of embryonic epithelium	0.0261939190023719
GO:0045177	apical part of cell	0.0267890120980656
GO:0043296	apical junction complex	0.0295120490852277
GO:0016327	apicolateral plasma membrane	0.0295120490852277
GO:0002009	morphogenesis of an epithelium	0.0391772335293738
GO:0015293	symporter activity	0.0412061163507711
GO:0035239	tube morphogenesis	0.0440692222694824
GO:0005911	intercellular junction	0.0440692222694824
GO:0030036	actin cytoskeleton organization and biogenesis	0.0441084378769543
GO:0030029	actin filament-based process	0.0460924290274504
GO:0015291	secondary active transmembrane transporter activity	0.0479801284305496

Relative expression of the co-expression cluster over median <br>Analyst:

---

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>

---

Uber Anatomy

Ontology term	p-value	n
gastrointestinal system	7.41e-16	47
intestine	4.66e-15	31
mucosa	7.60e-10	15
intestinal mucosa	8.26e-09	13
anatomical wall	8.26e-09	13
wall of intestine	8.26e-09	13
gastrointestinal system mucosa	8.26e-09	13
anatomical space	3.56e-07	57
organ component layer	5.50e-07	24

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

---

Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
{{{tfbs_overrepresentation_jaspar}}}