MCL coexpression mm9:2399

Phase1 CAGE Peaks

	Short description
Mm9::chr4:137024682..137024746,+	p1@Hspg2
Mm9::chr4:43644227..43644286,+	p1@ENSMUST00000174934
Mm9::chr4:43644289..43644309,+	p2@ENSMUST00000174934
Mm9::chr9:108382180..108382247,+	p1@Lamb2

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

---

GO ID	GO name	FDR corrected p-value
GO:0005604	basement membrane	0.00019298596771636
GO:0044420	extracellular matrix part	0.000213601073733654
GO:0005578	proteinaceous extracellular matrix	0.00131926473012659
GO:0043259	laminin-10 complex	0.00139695408386751
GO:0043256	laminin complex	0.00251606348391281
GO:0022610	biological adhesion	0.00251606348391281
GO:0007155	cell adhesion	0.00251606348391281
GO:0005605	basal lamina	0.0060496533918711
GO:0005201	extracellular matrix structural constituent	0.012397979188124
GO:0005615	extracellular space	0.0197932062335806
GO:0044421	extracellular region part	0.0202145680528581

Relative expression of the co-expression cluster over median <br>Analyst:

---

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>

---

Uber Anatomy

Ontology term	p-value	n
cardiovascular system	3.36e-09	23
circulatory system	3.36e-09	23
multi-cellular organism	1.32e-07	333
splanchnic layer of lateral plate mesoderm	1.80e-07	33

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

---

Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
{{{tfbs_overrepresentation_jaspar}}}