MCL coexpression mm9:2701

Phase1 CAGE Peaks

	Short description
Mm9::chr11:68673507..68673519,-	p9@Ndel1
Mm9::chr11:68673524..68673565,-	p5@Ndel1
Mm9::chr18:61696224..61696237,-	p4@Arhgef37

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0008090	retrograde axon cargo transport	0.00704385189127424
GO:0047496	vesicle transport along microtubule	0.00704385189127424
GO:0001833	inner cell mass cell proliferation	0.00704385189127424
GO:0060052	neurofilament cytoskeleton organization and biogenesis	0.00704385189127424
GO:0060053	neurofilament cytoskeleton	0.00704385189127424
GO:0021955	central nervous system neuron axonogenesis	0.00704385189127424
GO:0008088	axon cargo transport	0.00704385189127424
GO:0001832	blastocyst growth	0.00801238152632444
GO:0045104	intermediate filament cytoskeleton organization and biogenesis	0.00931353750068482
GO:0045103	intermediate filament-based process	0.00941314752743011
GO:0021954	central nervous system neuron development	0.00941314752743011
GO:0021953	central nervous system neuron differentiation	0.00986139264778393
GO:0001824	blastocyst development	0.0117578143108193
GO:0005813	centrosome	0.0142730683060031
GO:0008017	microtubule binding	0.0142730683060031
GO:0048589	developmental growth	0.0142730683060031
GO:0005815	microtubule organizing center	0.0142730683060031
GO:0015631	tubulin binding	0.0142730683060031
GO:0001764	neuron migration	0.0142730683060031
GO:0030424	axon	0.0150268840347184
GO:0000226	microtubule cytoskeleton organization and biogenesis	0.0150268840347184
GO:0007018	microtubule-based movement	0.0186021724946833
GO:0030705	cytoskeleton-dependent intracellular transport	0.0209554593765408
GO:0005875	microtubule associated complex	0.0209554593765408
GO:0043005	neuron projection	0.0220968242663307
GO:0001701	in utero embryonic development	0.0220968242663307
GO:0045111	intermediate filament cytoskeleton	0.0220968242663307
GO:0007409	axonogenesis	0.0267901166931463
GO:0048667	neuron morphogenesis during differentiation	0.0267901166931463
GO:0048812	neurite morphogenesis	0.0267901166931463
GO:0007017	microtubule-based process	0.0279936307420963
GO:0000904	cellular morphogenesis during differentiation	0.0282789936223216
GO:0005874	microtubule	0.0282789936223216
GO:0031175	neurite development	0.0282789936223216
GO:0048666	neuron development	0.0298507020689676
GO:0043009	chordate embryonic development	0.0298507020689676
GO:0009792	embryonic development ending in birth or egg hatching	0.0298507020689676
GO:0007417	central nervous system development	0.0299734434426064
GO:0032990	cell part morphogenesis	0.0317628577143738
GO:0030030	cell projection organization and biogenesis	0.0317628577143738
GO:0048858	cell projection morphogenesis	0.0317628577143738
GO:0016477	cell migration	0.0317628577143738
GO:0030182	neuron differentiation	0.0317628577143738
GO:0015630	microtubule cytoskeleton	0.0320495261052978
GO:0048699	generation of neurons	0.0339903321051276
GO:0051674	localization of cell	0.0339903321051276
GO:0006928	cell motility	0.0339903321051276
GO:0008092	cytoskeletal protein binding	0.0340117419892956
GO:0022008	neurogenesis	0.0340117419892956
GO:0042995	cell projection	0.0358954692379335
GO:0009790	embryonic development	0.0414178491206925
GO:0007010	cytoskeleton organization and biogenesis	0.0414178491206925
GO:0000902	cell morphogenesis	0.0414178491206925
GO:0032989	cellular structure morphogenesis	0.0414178491206925
GO:0008283	cell proliferation	0.0414178491206925
GO:0044430	cytoskeletal part	0.0457850372932825
GO:0046907	intracellular transport	0.049133956350362

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>

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Uber Anatomy

Ontology term	p-value	n
zone of skin	1.28e-08	5
skin epidermis	1.28e-08	5
skin of body	1.28e-08	5
integument	1.28e-08	5
surface	1.28e-08	5
outer epithelium	1.28e-08	5
integumental system	1.28e-08	5
enveloping layer of ectoderm	1.28e-08	5

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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