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CL:0000815

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Name:regulatory T cell
Namespace:cell;;efo
Definition:"A T cell which regulates overall immune responses as well as the responses of other T cell subsets through direct cell-cell contact and cytokine release." [GO_REF:0000031, GOC:add]
Xrefs:
links:

BTO:0004520

FMA:84070
Synonyms: "regulatory T lymphocyte" EXACT []
"regulatory T-cell" EXACT []
"regulatory T-lymphocyte" EXACT []
"suppressor T cell" BROAD []
"suppressor T lymphocyte" BROAD []
"suppressor T-cell" BROAD []
"suppressor T-lymphocyte" BROAD []
Comments:This cell type may express FoxP3 and CD25 and secretes IL-10 and TGF-beta.


Ontology association <br>Each term has an is_a parent in the Cell ontology, which has a linkage to an another entity and FANTOM5 samples.Libraries were grouped into mutually exclusive facets according to the FANTOM5 sample ontology mapping to Cell ontologies.<br><br>link to ontology dataset<br>data

Parents

is_a:CL:0002419(mature T cell)



Children


is a:CL:0000792 (CD4-positive, CD25-positive, alpha-beta regulatory T cell),FF:11943-126A8 (CD4+CD25+ regulatory T cells, antiCD3 CD28 stimulation, 06hr, pool1 (BalbcA)),FF:11944-126A9 (CD4+CD25+ regulatory T cells, antiCD3 CD28 stimulation, 06hr, pool1 (C57BL 6J)),FF:11946-126B2 (CD4+CD25+ regulatory T cells, PMA and ionomycin stimulation, 02hr, pool1 (BalbcA))

Ontology Tree: Loaded from BioPortal

Ontorolgy tree(Small window open)


FF samples<br>It includes FANTOM5 samples that overlay the Cell ontology.

Human (Homo sapiens)

  • 11780-124A7 (CD4+CD25+CD45RA+ naive regulatory T cells, donor1)
  • 11782-124A9 (CD4+CD25+CD45RA- memory regulatory T cells, donor1)
  • 11814-124E5 (CD4+CD25+ regulatory T cells, pool1 (C57BL_6J))
  • 11818-124E9 (CD4+CD25+ regulatory T cells, pool2 (Balb_cAJcl))
  • 11943-126A8 (CD4+CD25+ regulatory T cells, antiCD3 CD28 stimulation, 06hr, pool1 (BalbcA))
  • 11944-126A9 (CD4+CD25+ regulatory T cells, antiCD3 CD28 stimulation, 06hr, pool1 (C57BL 6J))
  • 11945-126B1 (CD4+CD25+ regulatory T cells, PMA and ionomycin stimulation, 02hr, pool1 (C57BL 6J))
  • 11946-126B2 (CD4+CD25+ regulatory T cells, PMA and ionomycin stimulation, 02hr, pool1 (BalbcA))

Mouse (Mus musculus)

  • 11780-124A7 (CD4+CD25+CD45RA+ naive regulatory T cells, donor1)
  • 11782-124A9 (CD4+CD25+CD45RA- memory regulatory T cells, donor1)
  • 11814-124E5 (CD4+CD25+ regulatory T cells, pool1 (C57BL_6J))
  • 11818-124E9 (CD4+CD25+ regulatory T cells, pool2 (Balb_cAJcl))
  • 11943-126A8 (CD4+CD25+ regulatory T cells, antiCD3 CD28 stimulation, 06hr, pool1 (BalbcA))
  • 11944-126A9 (CD4+CD25+ regulatory T cells, antiCD3 CD28 stimulation, 06hr, pool1 (C57BL 6J))
  • 11945-126B1 (CD4+CD25+ regulatory T cells, PMA and ionomycin stimulation, 02hr, pool1 (C57BL 6J))
  • 11946-126B2 (CD4+CD25+ regulatory T cells, PMA and ionomycin stimulation, 02hr, pool1 (BalbcA))


Enrichment analysis: top 100 FFCP enriched with this ontology termTOP 100 FANTOM5 Cage Peaks enriched with CL:0000815 (regulatory T cell), sorted by p-values <br>Analyst: Hideya Kawaji<br><br>link to source dataset <br>human : data <br>mouse : data

P-valueFFCPShort description
4.61e-131FFCP PHASE1:Hg19::chr1:113160702..113160706,-#_7ab95dd728078da90f616e2dae394ac4p21@ST7L
4.61e-131FFCP PHASE2:Hg19::chr1:113160702..113160706,-#_7ab95dd728078da90f616e2dae394ac4p21@ST7L
5.68e-99FFCP PHASE2:Hg19::chr11:111410267..111410269,+#_f728bf5dc8a8de558b9e23cc82f780cfp@chr11:111410267..111410269, +
5.68e-99FFCP PHASE1:Hg19::chr11:111410267..111410269,+#_f728bf5dc8a8de558b9e23cc82f780cfp@chr11:111410267..111410269, +
1.55e-98FFCP PHASE2:Hg19::chr3:73015629..73015632,+#_b0723bc5add031d9fbb142c1f032198bp@chr3:73015629..73015632, +
1.55e-98FFCP PHASE1:Hg19::chr3:73015629..73015632,+#_b0723bc5add031d9fbb142c1f032198bp@chr3:73015629..73015632, +
3.07e-86FFCP PHASE1:Mm9::chrX:7161059..7161081,-#_5884893199fa68790cd27702941e5924p@chrX:7161059..7161081, -
3.07e-86FFCP PHASE1:Mm9::chr8:74526430..74526446,-#_5884893199fa68790cd27702941e5924p@chr8:74526430..74526446, -
3.07e-86FFCP PHASE1:Mm9::chr4:32512204..32512214,+#_5884893199fa68790cd27702941e5924p@chr4:32512204..32512214, +
3.07e-86FFCP PHASE2:Mm9::chr15:5504747..5504756,+#_5884893199fa68790cd27702941e5924p@chr15:5504747..5504756, +
3.07e-86FFCP PHASE2:Mm9::chrX:7147964..7147979,-#_5884893199fa68790cd27702941e5924p@chrX:7147964..7147979, -
3.07e-86FFCP PHASE2:Mm9::chr5:124484631..124484634,-#_5884893199fa68790cd27702941e5924p@chr5:124484631..124484634, -
3.07e-86FFCP PHASE1:Mm9::chr5:124484631..124484634,-#_5884893199fa68790cd27702941e5924p@chr5:124484631..124484634, -
3.07e-86FFCP PHASE1:Mm9::chr13:46831423..46831426,+#_5884893199fa68790cd27702941e5924p@chr13:46831423..46831426, +
3.07e-86FFCP PHASE1:Mm9::chrX:148215171..148215179,+#_5884893199fa68790cd27702941e5924p@chrX:148215171..148215179, +
3.07e-86FFCP PHASE2:Mm9::chr3:142250588..142250598,+#_5884893199fa68790cd27702941e5924p@chr3:142250588..142250598, +
3.07e-86FFCP PHASE1:Mm9::chr1:69727854..69727859,+#_5884893199fa68790cd27702941e5924p@chr1:69727854..69727859, +
3.07e-86FFCP PHASE1:Mm9::chr17:12884884..12884887,-#_5884893199fa68790cd27702941e5924p@chr17:12884884..12884887, -
3.07e-86FFCP PHASE1:Mm9::chr11:4397528..4397535,-#_5884893199fa68790cd27702941e5924p@chr11:4397528..4397535, -
3.07e-86FFCP PHASE2:Mm9::chr17:29566022..29566044,+#_5884893199fa68790cd27702941e5924p@chr17:29566022..29566044, +
3.07e-86FFCP PHASE2:Mm9::chr1:60944156..60944166,+#_5884893199fa68790cd27702941e5924p@chr1:60944156..60944166, +
3.07e-86FFCP PHASE1:Mm9::chr13:105413537..105413540,+#_5884893199fa68790cd27702941e5924p@chr13:105413537..105413540, +
3.07e-86FFCP PHASE1:Mm9::chr17:26688385..26688421,+#_5884893199fa68790cd27702941e5924p@chr17:26688385..26688421, +
3.07e-86FFCP PHASE2:Mm9::chr10:13765981..13765988,+#_5884893199fa68790cd27702941e5924p@chr10:13765981..13765988, +
3.07e-86FFCP PHASE1:Mm9::chr7:106142059..106142061,-#_5884893199fa68790cd27702941e5924p@chr7:106142059..106142061, -
3.07e-86FFCP PHASE1:Mm9::chr12:111613723..111613727,+#_5884893199fa68790cd27702941e5924p@chr12:111613723..111613727, +
3.07e-86FFCP PHASE1:Mm9::chr10:18908457..18908466,-#_5884893199fa68790cd27702941e5924p@chr10:18908457..18908466, -
3.07e-86FFCP PHASE2:Mm9::chr17:35164610..35164618,-#_5884893199fa68790cd27702941e5924p5@Ng23
3.07e-86FFCP PHASE2:Mm9::chr12:109240261..109240265,+#_5884893199fa68790cd27702941e5924p@chr12:109240261..109240265, +
3.07e-86FFCP PHASE2:Mm9::chr10:13779506..13779514,-#_5884893199fa68790cd27702941e5924p@chr10:13779506..13779514, -
3.07e-86FFCP PHASE2:Mm9::chr1:69728149..69728150,+#_5884893199fa68790cd27702941e5924p@chr1:69728149..69728150, +
3.07e-86FFCP PHASE2:Mm9::chr7:132631174..132631179,+#_5884893199fa68790cd27702941e5924p@chr7:132631174..132631179, +
3.07e-86FFCP PHASE2:Mm9::chr1:60967911..60967916,+#_5884893199fa68790cd27702941e5924p@chr1:60967911..60967916, +
3.07e-86FFCP PHASE2:Mm9::chr15:59357447..59357449,+#_5884893199fa68790cd27702941e5924p@chr15:59357447..59357449, +
3.07e-86FFCP PHASE2:Mm9::chr17:12808149..12808156,+#_5884893199fa68790cd27702941e5924p@chr17:12808149..12808156, +
3.07e-86FFCP PHASE1:Mm9::chr9:14708334..14708341,-#_5884893199fa68790cd27702941e5924p11@Folr4
3.07e-86FFCP PHASE2:Mm9::chr9:14812338..14812345,-#_5884893199fa68790cd27702941e5924p@chr9:14812338..14812345, -
3.07e-86FFCP PHASE2:Mm9::chr8:74526480..74526487,-#_5884893199fa68790cd27702941e5924p@chr8:74526480..74526487, -
3.07e-86FFCP PHASE1:Mm9::chr4:151490501..151490511,+#_5884893199fa68790cd27702941e5924p5@Tnfrsf25
3.07e-86FFCP PHASE2:Mm9::chr10:22023694..22023695,-#_5884893199fa68790cd27702941e5924p@chr10:22023694..22023695, -
3.07e-86FFCP PHASE1:Mm9::chr13:43627067..43627074,+#_5884893199fa68790cd27702941e5924p@chr13:43627067..43627074, +
3.07e-86FFCP PHASE2:Mm9::chr5:150229693..150229735,+#_5884893199fa68790cd27702941e5924p@chr5:150229693..150229735, +
3.07e-86FFCP PHASE1:Mm9::chr17:12807573..12807582,+#_5884893199fa68790cd27702941e5924p@chr17:12807573..12807582, +
3.07e-86FFCP PHASE1:Mm9::chr14:101876628..101876637,-#_5884893199fa68790cd27702941e5924p@chr14:101876628..101876637, -
3.07e-86FFCP PHASE1:Mm9::chrX:7154622..7154647,+#_5884893199fa68790cd27702941e5924p@chrX:7154622..7154647, +
3.07e-86FFCP PHASE1:Mm9::chr3:142250588..142250598,+#_5884893199fa68790cd27702941e5924p@chr3:142250588..142250598, +
3.07e-86FFCP PHASE2:Mm9::chr4:155400229..155400241,+#_5884893199fa68790cd27702941e5924p3@Tnfrsf18
3.07e-86FFCP PHASE1:Mm9::chr17:35164593..35164602,-#_5884893199fa68790cd27702941e5924p6@Ng23
3.07e-86FFCP PHASE2:Mm9::chrX:7161574..7161577,+#_5884893199fa68790cd27702941e5924p@chrX:7161574..7161577, +
3.07e-86FFCP PHASE1:Mm9::chr15:59356135..59356143,-#_5884893199fa68790cd27702941e5924p@chr15:59356135..59356143, -
3.07e-86FFCP PHASE1:Mm9::chr1:60967956..60967966,+#_5884893199fa68790cd27702941e5924p@chr1:60967956..60967966, +
3.07e-86FFCP PHASE1:Mm9::chr1:162743278..162743283,-#_5884893199fa68790cd27702941e5924p@chr1:162743278..162743283, -
3.07e-86FFCP PHASE1:Mm9::chr10:13765981..13765988,+#_5884893199fa68790cd27702941e5924p@chr10:13765981..13765988, +
3.07e-86FFCP PHASE1:Mm9::chr16:89837454..89837462,-#_5884893199fa68790cd27702941e5924p@chr16:89837454..89837462, -
3.07e-86FFCP PHASE2:Mm9::chr4:102823636..102823677,+#_5884893199fa68790cd27702941e5924p@chr4:102823636..102823677, +
3.07e-86FFCP PHASE1:Mm9::chr6:94615187..94615214,-#_5884893199fa68790cd27702941e5924p@chr6:94615187..94615214, -
3.07e-86FFCP PHASE1:Mm9::chrX:7161176..7161185,-#_5884893199fa68790cd27702941e5924p@chrX:7161176..7161185, -
3.07e-86FFCP PHASE2:Mm9::chr1:162743278..162743283,-#_5884893199fa68790cd27702941e5924p@chr1:162743278..162743283, -
3.07e-86FFCP PHASE1:Mm9::chr16:36770181..36770184,-#_5884893199fa68790cd27702941e5924p@chr16:36770181..36770184, -
3.07e-86FFCP PHASE2:Mm9::chr13:43627067..43627074,+#_5884893199fa68790cd27702941e5924p@chr13:43627067..43627074, +
3.07e-86FFCP PHASE1:Mm9::chr4:102823636..102823677,+#_5884893199fa68790cd27702941e5924p@chr4:102823636..102823677, +
3.07e-86FFCP PHASE2:Mm9::chr12:15821719..15821726,+#_5884893199fa68790cd27702941e5924p@chr12:15821719..15821726, +
3.07e-86FFCP PHASE2:Mm9::chr12:114668438..114668451,+#_5884893199fa68790cd27702941e5924p@chr12:114668438..114668451, +
3.07e-86FFCP PHASE2:Mm9::chr9:69148201..69148218,-#_5884893199fa68790cd27702941e5924p@chr9:69148201..69148218, -
3.07e-86FFCP PHASE2:Mm9::chr15:59354543..59354548,+#_5884893199fa68790cd27702941e5924p@chr15:59354543..59354548, +
3.07e-86FFCP PHASE1:Mm9::chr1:69728149..69728150,+#_5884893199fa68790cd27702941e5924p@chr1:69728149..69728150, +
3.07e-86FFCP PHASE1:Mm9::chr11:4397552..4397557,-#_5884893199fa68790cd27702941e5924p@chr11:4397552..4397557, -
3.07e-86FFCP PHASE2:Mm9::chr7:121283156..121283178,+#_5884893199fa68790cd27702941e5924p@chr7:121283156..121283178, +
3.07e-86FFCP PHASE2:Mm9::chr11:4397528..4397535,-#_5884893199fa68790cd27702941e5924p@chr11:4397528..4397535, -
3.07e-86FFCP PHASE2:Mm9::chr7:105641398..105641405,-#_5884893199fa68790cd27702941e5924p@chr7:105641398..105641405, -
3.07e-86FFCP PHASE2:Mm9::chr9:14707496..14707511,-#_5884893199fa68790cd27702941e5924p@chr9:14707496..14707511, -
3.07e-86FFCP PHASE2:Mm9::chr15:12160236..12160239,+#_5884893199fa68790cd27702941e5924p@chr15:12160236..12160239, +
3.07e-86FFCP PHASE2:Mm9::chr3:101090598..101090601,+#_5884893199fa68790cd27702941e5924p@chr3:101090598..101090601, +
3.07e-86FFCP PHASE2:Mm9::chr10:18781172..18781174,+#_5884893199fa68790cd27702941e5924p@chr10:18781172..18781174, +
3.07e-86FFCP PHASE2:Mm9::chrX:7157611..7157617,+#_5884893199fa68790cd27702941e5924p4@Foxp3
3.07e-86FFCP PHASE1:Mm9::chr10:58784974..58784979,-#_5884893199fa68790cd27702941e5924p@chr10:58784974..58784979, -
3.07e-86FFCP PHASE2:Mm9::chr1:69729950..69729959,-#_5884893199fa68790cd27702941e5924p@chr1:69729950..69729959, -
3.07e-86FFCP PHASE2:Mm9::chr17:26709187..26709203,-#_5884893199fa68790cd27702941e5924p@chr17:26709187..26709203, -
3.07e-86FFCP PHASE1:Mm9::chr12:108370128..108370136,-#_5884893199fa68790cd27702941e5924p@chr12:108370128..108370136, -
3.07e-86FFCP PHASE1:Mm9::chr7:132631174..132631179,+#_5884893199fa68790cd27702941e5924p@chr7:132631174..132631179, +
3.07e-86FFCP PHASE2:Mm9::chr12:111613723..111613727,+#_5884893199fa68790cd27702941e5924p@chr12:111613723..111613727, +
3.07e-86FFCP PHASE1:Mm9::chr16:89826368..89826391,+#_5884893199fa68790cd27702941e5924p@chr16:89826368..89826391, +
3.07e-86FFCP PHASE2:Mm9::chr1:60967956..60967966,+#_5884893199fa68790cd27702941e5924p@chr1:60967956..60967966, +
3.07e-86FFCP PHASE1:Mm9::chr2:32306609..32306610,+#_5884893199fa68790cd27702941e5924p@chr2:32306609..32306610, +
3.07e-86FFCP PHASE2:Mm9::chr17:12884847..12884852,-#_5884893199fa68790cd27702941e5924p@chr17:12884847..12884852, -
3.07e-86FFCP PHASE1:Mm9::chr10:89010973..89010996,-#_5884893199fa68790cd27702941e5924p@chr10:89010973..89010996, -
3.07e-86FFCP PHASE2:Mm9::chr4:151490501..151490511,+#_5884893199fa68790cd27702941e5924p5@Tnfrsf25
3.07e-86FFCP PHASE2:Mm9::chr8:74526522..74526532,-#_5884893199fa68790cd27702941e5924p@chr8:74526522..74526532, -
3.07e-86FFCP PHASE1:Mm9::chr10:22023694..22023695,-#_5884893199fa68790cd27702941e5924p@chr10:22023694..22023695, -
3.07e-86FFCP PHASE2:Mm9::chr2:78812885..78812894,+#_5884893199fa68790cd27702941e5924p@chr2:78812885..78812894, +
3.07e-86FFCP PHASE1:Mm9::chr4:151490543..151490552,+#_5884893199fa68790cd27702941e5924p6@Tnfrsf25
3.07e-86FFCP PHASE2:Mm9::chr7:106142059..106142061,-#_5884893199fa68790cd27702941e5924p@chr7:106142059..106142061, -
3.07e-86FFCP PHASE1:Mm9::chr9:14706346..14706355,-#_5884893199fa68790cd27702941e5924p@chr9:14706346..14706355, -
3.07e-86FFCP PHASE1:Mm9::chr1:69595515..69595518,-#_5884893199fa68790cd27702941e5924p@chr1:69595515..69595518, -
3.07e-86FFCP PHASE1:Mm9::chr17:12808149..12808156,+#_5884893199fa68790cd27702941e5924p@chr17:12808149..12808156, +
3.07e-86FFCP PHASE2:Mm9::chr6:106741792..106741797,+#_5884893199fa68790cd27702941e5924p@chr6:106741792..106741797, +
3.07e-86FFCP PHASE1:Mm9::chr17:35164610..35164618,-#_5884893199fa68790cd27702941e5924p5@Ng23
3.07e-86FFCP PHASE2:Mm9::chrX:7170204..7170205,+#_5884893199fa68790cd27702941e5924p@chrX:7170204..7170205, +
3.07e-86FFCP PHASE1:Mm9::chr10:18781172..18781174,+#_5884893199fa68790cd27702941e5924p@chr10:18781172..18781174, +
3.07e-86FFCP PHASE1:Mm9::chr1:60970179..60970192,-#_5884893199fa68790cd27702941e5924p@chr1:60970179..60970192, -

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