CL:0000127
From FANTOM5_SSTAR
| Name: | astrocyte | ||
|---|---|---|---|
| Namespace: | efo | ||
| Definition: | "A class of large neuroglial (macroglial) cells in the central nervous system - the largest and most numerous neuroglial cells in the brain and spinal cord. Astrocytes (from 'star' cells) are irregularly shaped with many long processes, including those with 'end feet' which form the glial (limiting) membrane and directly and indirectly contribute to the blood-brain barrier. They regulate the extracellular ionic and chemical environment, and 'reactive astrocytes' (along with microglia) respond to injury." [GOC:dsd, GOC:tfm, MESH:A.08.637.200, MESH:D001253, PMID:11746784, PMID:12162730, PMID:12898703, PMID:20942978] | ||
| Xrefs: |
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| Synonyms: | "astrocytic glia" EXACT [] | ||
| Comments: | Astrocytes are reportedly CD68-negative, CD121a-positive, CD184-positive, CD192-positive, CRF-positive, EGFR-positive, GFAP-positive, GLUT1-positive, MBP-negative, and NGFR-positive. |
Ontology association <br>Each term has an is_a parent in the Cell ontology, which has a linkage to an another entity and FANTOM5 samples.Libraries were grouped into mutually exclusive facets according to the FANTOM5 sample ontology mapping to Cell ontologies.<br><br>link to ontology dataset<br>data
Parents
| is_a: | CL:0000128(oligodendrocyte),EFO:0002963() |
|---|---|
| part_of: | UBERON:0001017(central nervous system) |
Children
| is a: | CL:0002603 (astrocyte of the cerebellum),CL:0002606 (astrocyte of the spinal cord),CL:0012000 (astrocyte of the forebrain) |
|---|---|
| derives from: | FF:0000105 (mouse astrocyte sample),FF:0100101 (astrocytoma cell line sample) |
Ontology Tree: Loaded from BioPortal
Ontorolgy tree(Small window open)
FF samples<br>It includes FANTOM5 samples that overlay the Cell ontology.
Human (Homo sapiens)
- 10425-106D2 (astrocytoma cell line:TM-31)
- 10753-110D6
- 10762-110E6
- 10763-110E7
- 11235-116D2 (Astrocyte - cerebral cortex, donor1)
- 11316-117D2 (Astrocyte - cerebral cortex, donor2)
- 11392-118C6 (Astrocyte - cerebral cortex, donor3)
- 11500-119F6 (Astrocyte - cerebellum, donor1)
- 11550-120C2 (Mouse Astrocytes - cerebellar, donor2)
- 11551-120C3 (Mouse Astrocytes - hippocampus, donor2)
... further results Mouse (Mus musculus)
- 10425-106D2 (astrocytoma cell line:TM-31)
- 10753-110D6
- 10762-110E6
- 10763-110E7
- 11235-116D2 (Astrocyte - cerebral cortex, donor1)
- 11316-117D2 (Astrocyte - cerebral cortex, donor2)
- 11392-118C6 (Astrocyte - cerebral cortex, donor3)
- 11500-119F6 (Astrocyte - cerebellum, donor1)
- 11550-120C2 (Mouse Astrocytes - cerebellar, donor2)
- 11551-120C3 (Mouse Astrocytes - hippocampus, donor2)
Enrichment analysis: top 100 FFCP enriched with this ontology termTOP 100 FANTOM5 Cage Peaks enriched with CL:0000127 (astrocyte), sorted by p-values <br>Analyst: Hideya Kawaji<br><br>link to source dataset <br>human : data <br>mouse : data
| P-value | FFCP | Short description |
|---|---|---|
| 6.94e-140 | FFCP PHASE2:Hg19::chr4:169553987..169553999,+#_8a295bf52f97a6bfa5bff7ee634d5236 | p@chr4:169553987..169553999, + |
| 6.94e-140 | FFCP PHASE1:Hg19::chr4:169553987..169553999,+#_8a295bf52f97a6bfa5bff7ee634d5236 | p@chr4:169553987..169553999, + |
| 1.28e-84 | FFCP PHASE2:Hg19::chr9:122602283..122602290,-#_791e3644dcbe78a3d2f11a59400560a3 | p@chr9:122602283..122602290, - |
| 1.28e-84 | FFCP PHASE1:Hg19::chr9:122602283..122602290,-#_791e3644dcbe78a3d2f11a59400560a3 | p@chr9:122602283..122602290, - |
| 6.32e-78 | FFCP PHASE2:Hg19::chr2:48919725..48919761,+#_1b2b45c0b5b708f4036db58b1ba86afd | p@chr2:48919725..48919761, + |
| 6.32e-78 | FFCP PHASE1:Hg19::chr2:48919725..48919761,+#_1b2b45c0b5b708f4036db58b1ba86afd | p@chr2:48919725..48919761, + |
| 8.34e-78 | FFCP PHASE2:Hg19::chr2:48919688..48919703,+#_02620eedcb4c92d2428cf4f2b736046f | p@chr2:48919688..48919703, + |
| 8.34e-78 | FFCP PHASE1:Hg19::chr2:48919688..48919703,+#_02620eedcb4c92d2428cf4f2b736046f | p@chr2:48919688..48919703, + |
| 1.79e-75 | FFCP PHASE1:Hg19::chr9:127025189..127025200,+#_d7b570f1a2b31a263640619e7014fa36 | p1@ENST00000437461 |
| 1.79e-75 | FFCP PHASE2:Hg19::chr9:127025189..127025200,+#_d7b570f1a2b31a263640619e7014fa36 | p1@ENST00000437461 |
| 1.79e-75 | FFCP PHASE2:Hg19::chr11:68808268..68808276,-#_d7b570f1a2b31a263640619e7014fa36 | p@chr11:68808268..68808276, - |
| 1.79e-75 | FFCP PHASE1:Hg19::chr11:68808268..68808276,-#_d7b570f1a2b31a263640619e7014fa36 | p@chr11:68808268..68808276, - |
| 2.17e-75 | FFCP PHASE1:Hg19::chr13:99349888..99349893,+#_b1ab64d8daba86b2f21e5b68c657976a | p@chr13:99349888..99349893, + |
| 2.17e-75 | FFCP PHASE2:Hg19::chr13:99349888..99349893,+#_b1ab64d8daba86b2f21e5b68c657976a | p@chr13:99349888..99349893, + |
| 2.83e-68 | FFCP PHASE2:Hg19::chr22:30176932..30176938,+#_b9c6f74bd0fa89dd78022904e9bc0818 | p@chr22:30176932..30176938, + |
| 2.83e-68 | FFCP PHASE1:Hg19::chr22:30176932..30176938,+#_b9c6f74bd0fa89dd78022904e9bc0818 | p@chr22:30176932..30176938, + |
| 2.25e-65 | FFCP PHASE1:Mm9::chr8:96704054..96704065,-#_a8b25e7d5c017c6692bf24b9e8d2a6f9 | p@chr8:96704054..96704065, - |
| 2.25e-65 | FFCP PHASE2:Mm9::chr8:96704054..96704065,-#_a8b25e7d5c017c6692bf24b9e8d2a6f9 | p@chr8:96704054..96704065, - |
| 1.33e-60 | FFCP PHASE1:Mm9::chr1:72895689..72895698,-#_e63b1162d3d693ccf41d78da6e685158 | p@chr1:72895689..72895698, - |
| 1.33e-60 | FFCP PHASE2:Mm9::chr14:70592673..70592699,-#_e63b1162d3d693ccf41d78da6e685158 | p@chr14:70592673..70592699, - |
| 1.33e-60 | FFCP PHASE1:Mm9::chr14:70592673..70592699,-#_e63b1162d3d693ccf41d78da6e685158 | p@chr14:70592673..70592699, - |
| 1.33e-60 | FFCP PHASE2:Mm9::chr1:72895689..72895698,-#_e63b1162d3d693ccf41d78da6e685158 | p@chr1:72895689..72895698, - |
| 2.34e-60 | FFCP PHASE1:Mm9::chr1:72898728..72898736,+#_fc29129dfa30ad385d1c4acace1b1006 | p@chr1:72898728..72898736, + |
| 2.34e-60 | FFCP PHASE2:Mm9::chr1:72898728..72898736,+#_fc29129dfa30ad385d1c4acace1b1006 | p@chr1:72898728..72898736, + |
| 3.91e-58 | FFCP PHASE2:Mm9::chr9:43915826..43915844,+#_6cf8abf1a685241ff628879967341089 | p@chr9:43915826..43915844, + |
| 3.91e-58 | FFCP PHASE2:Mm9::chr6:92777773..92777784,+#_6cf8abf1a685241ff628879967341089 | p4@ENSMUST00000133858 |
| 3.91e-58 | FFCP PHASE1:Mm9::chr6:92777773..92777784,+#_6cf8abf1a685241ff628879967341089 | p4@ENSMUST00000133858 |
| 3.91e-58 | FFCP PHASE1:Mm9::chr9:43915826..43915844,+#_6cf8abf1a685241ff628879967341089 | p@chr9:43915826..43915844, + |
| 3.91e-58 | FFCP PHASE1:Mm9::chr7:29152679..29152684,-#_6cf8abf1a685241ff628879967341089 | p@chr7:29152679..29152684, - |
| 3.91e-58 | FFCP PHASE2:Mm9::chr7:29152679..29152684,-#_6cf8abf1a685241ff628879967341089 | p@chr7:29152679..29152684, - |
| 4.76e-57 | FFCP PHASE1:Hg19::chr8:32488262..32488265,+#_5d28eab50e7aed23efc1c668e22eb1f6 | p@chr8:32488262..32488265, + |
| 4.76e-57 | FFCP PHASE2:Hg19::chr8:32488262..32488265,+#_5d28eab50e7aed23efc1c668e22eb1f6 | p@chr8:32488262..32488265, + |
| 8.4e-54 | FFCP PHASE1:Hg19::chr6:45296191..45296203,+#_0807433a110c6ec59dc9c9bcaff11b22 | p13@RUNX2 |
| 8.4e-54 | FFCP PHASE2:Hg19::chr6:45296191..45296203,+#_0807433a110c6ec59dc9c9bcaff11b22 | p13@RUNX2 |
| 2.53e-52 | FFCP PHASE2:Mm9::chr19:17030554..17030565,+#_3bb2474698ee3693b0e0acc970c1c9c9 | p5@Prune2 |
| 2.53e-52 | FFCP PHASE1:Mm9::chr19:17030554..17030565,+#_3bb2474698ee3693b0e0acc970c1c9c9 | p5@Prune2 |
| 3.23e-52 | FFCP PHASE1:Mm9::chr14:70592626..70592638,-#_999fe89f67240e6321ae50e17291b0fe | p@chr14:70592626..70592638, - |
| 3.23e-52 | FFCP PHASE2:Mm9::chr14:70592626..70592638,-#_999fe89f67240e6321ae50e17291b0fe | p@chr14:70592626..70592638, - |
| 4.11e-52 | FFCP PHASE2:Mm9::chr1:72873192..72873206,+#_6f7f0fce1fbf13d5c8b76fdd4f632aaa | p@chr1:72873192..72873206, + |
| 4.11e-52 | FFCP PHASE1:Mm9::chr1:72873192..72873206,+#_6f7f0fce1fbf13d5c8b76fdd4f632aaa | p@chr1:72873192..72873206, + |
| 4.11e-52 | FFCP PHASE2:Mm9::chr8:28132545..28132551,+#_6f7f0fce1fbf13d5c8b76fdd4f632aaa | p@chr8:28132545..28132551, + |
| 4.11e-52 | FFCP PHASE1:Mm9::chr8:28132545..28132551,+#_6f7f0fce1fbf13d5c8b76fdd4f632aaa | p@chr8:28132545..28132551, + |
| 5.23e-52 | FFCP PHASE2:Mm9::chr9:37174919..37174932,+#_2f633da3da5090c946d6651ea044e75c | p3@Hepacam |
| 5.23e-52 | FFCP PHASE1:Mm9::chr1:72898789..72898796,+#_2f633da3da5090c946d6651ea044e75c | p@chr1:72898789..72898796, + |
| 5.23e-52 | FFCP PHASE1:Mm9::chr9:37174919..37174932,+#_2f633da3da5090c946d6651ea044e75c | p3@Hepacam |
| 5.23e-52 | FFCP PHASE2:Mm9::chr1:72898789..72898796,+#_2f633da3da5090c946d6651ea044e75c | p@chr1:72898789..72898796, + |
| 2.3e-51 | FFCP PHASE1:Hg19::chr7:42192092..42192108,-#_d29e9601465005cedb0a4ee5d5832adc | p13@GLI3 |
| 2.3e-51 | FFCP PHASE2:Hg19::chr7:42192092..42192108,-#_d29e9601465005cedb0a4ee5d5832adc | p13@GLI3 |
| 3.85e-51 | FFCP PHASE1:Hg19::chr20:35856764..35856768,+#_0b3e3697cb511aac9d238a130e09b0c3 | p25@RPN2 |
| 3.85e-51 | FFCP PHASE2:Hg19::chr20:35856764..35856768,+#_0b3e3697cb511aac9d238a130e09b0c3 | p25@RPN2 |
| 5.43e-51 | FFCP PHASE1:Hg19::chr14:33403217..33403226,+#_d00908c062cb3504ce18e7f38a9efeda | p@chr14:33403217..33403226, + |
| 5.43e-51 | FFCP PHASE2:Hg19::chr14:33403217..33403226,+#_d00908c062cb3504ce18e7f38a9efeda | p@chr14:33403217..33403226, + |
| 6.95e-51 | FFCP PHASE1:Hg19::chr4:169553961..169553972,+#_cb8864eee0cc2d5377aa1582c51739d2 | p@chr4:169553961..169553972, + |
| 6.95e-51 | FFCP PHASE2:Hg19::chr4:169553961..169553972,+#_cb8864eee0cc2d5377aa1582c51739d2 | p@chr4:169553961..169553972, + |
| 7.9e-51 | FFCP PHASE2:Hg19::chr1:98642833..98642844,+#_f4087e281ce6c2373d83cabb2af06dc5 | p@chr1:98642833..98642844, + |
| 7.9e-51 | FFCP PHASE1:Hg19::chr1:98642833..98642844,+#_f4087e281ce6c2373d83cabb2af06dc5 | p@chr1:98642833..98642844, + |
| 8.98e-51 | FFCP PHASE1:Hg19::chr1:98518907..98518920,+#_f28408075f91fc7bdc0e34929e7de4bb | p@chr1:98518907..98518920, + |
| 8.98e-51 | FFCP PHASE2:Hg19::chr1:98518907..98518920,+#_f28408075f91fc7bdc0e34929e7de4bb | p@chr1:98518907..98518920, + |
| 4.49e-48 | FFCP PHASE1:Mm9::chr1:72895732..72895747,-#_e19ad27cd468cc9fcbe99f1fc2c6916c | p@chr1:72895732..72895747, - |
| 4.49e-48 | FFCP PHASE2:Mm9::chr1:72895732..72895747,-#_e19ad27cd468cc9fcbe99f1fc2c6916c | p@chr1:72895732..72895747, - |
| 1.09e-46 | FFCP PHASE1:Mm9::chr8:73022520..73022524,+#_6f36edea4e98ab0158bfb4762e16999f | p@chr8:73022520..73022524, + |
| 1.09e-46 | FFCP PHASE1:Mm9::chr1:72895881..72895885,-#_6f36edea4e98ab0158bfb4762e16999f | p@chr1:72895881..72895885, - |
| 1.09e-46 | FFCP PHASE2:Mm9::chr1:72895881..72895885,-#_6f36edea4e98ab0158bfb4762e16999f | p@chr1:72895881..72895885, - |
| 1.09e-46 | FFCP PHASE2:Mm9::chr8:73022520..73022524,+#_6f36edea4e98ab0158bfb4762e16999f | p@chr8:73022520..73022524, + |
| 1.12e-46 | FFCP PHASE1:Hg19::chr4:77356957..77356973,+#_fa3802f85877db27705ceab8a1efc08b | p20@SHROOM3 |
| 1.12e-46 | FFCP PHASE2:Hg19::chr4:77356957..77356973,+#_fa3802f85877db27705ceab8a1efc08b | p20@SHROOM3 |
| 1.42e-46 | FFCP PHASE1:Mm9::chr19:40457627..40457636,-#_3f2f06d7e53a478eed0f5b6140acc02c | p9@Sorbs1 |
| 1.42e-46 | FFCP PHASE2:Mm9::chr19:40457627..40457636,-#_3f2f06d7e53a478eed0f5b6140acc02c | p9@Sorbs1 |
| 1.86e-46 | FFCP PHASE1:Mm9::chr3:88990698..88990709,+#_963b846113d836c503b763758882c049 | p@chr3:88990698..88990709, + |
| 1.86e-46 | FFCP PHASE2:Mm9::chr3:88990698..88990709,+#_963b846113d836c503b763758882c049 | p@chr3:88990698..88990709, + |
| 4.13e-46 | FFCP PHASE1:Mm9::chr19:8788816..8788826,-#_b4a930b8a484ef1fe85cfd5923e10935 | p14@Slc3a2 |
| 4.13e-46 | FFCP PHASE2:Mm9::chr19:8788816..8788826,-#_b4a930b8a484ef1fe85cfd5923e10935 | p14@Slc3a2 |
| 4.13e-46 | FFCP PHASE1:Mm9::chr11:7114172..7114182,-#_b4a930b8a484ef1fe85cfd5923e10935 | p4@Igfbp3 |
| 4.13e-46 | FFCP PHASE2:Mm9::chr11:7114172..7114182,-#_b4a930b8a484ef1fe85cfd5923e10935 | p4@Igfbp3 |
| 4.13e-46 | FFCP PHASE1:Mm9::chr19:8788690..8788697,-#_b4a930b8a484ef1fe85cfd5923e10935 | p17@Slc3a2 |
| 4.13e-46 | FFCP PHASE2:Mm9::chr19:8788690..8788697,-#_b4a930b8a484ef1fe85cfd5923e10935 | p17@Slc3a2 |
| 7.81e-46 | FFCP PHASE1:Mm9::chr11:7110185..7110197,-#_cfdfc6a7a5cf6c8813786eb0a4e7c671 | p@chr11:7110185..7110197, - |
| 7.81e-46 | FFCP PHASE2:Mm9::chr11:7110185..7110197,-#_cfdfc6a7a5cf6c8813786eb0a4e7c671 | p@chr11:7110185..7110197, - |
| 1.19e-45 | FFCP PHASE2:Mm9::chr8:11006242..11006246,-#_83fd1a22ab8abff0093ab084fbedbfa2 | p@chr8:11006242..11006246, - |
| 1.19e-45 | FFCP PHASE1:Mm9::chr8:11006242..11006246,-#_83fd1a22ab8abff0093ab084fbedbfa2 | p@chr8:11006242..11006246, - |
| 1.77e-45 | FFCP PHASE2:Hg19::chr5:135540733..135540788,-#_6a04854343b6b36aa2b998fd3b6daec5 | p@chr5:135540733..135540788, - |
| 1.77e-45 | FFCP PHASE1:Hg19::chr5:135540733..135540788,-#_6a04854343b6b36aa2b998fd3b6daec5 | p@chr5:135540733..135540788, - |
| 5.38e-44 | FFCP PHASE1:Mm9::chr1:154940591..154940634,+#_343cb6382c7ce04c0b0223adb6fb5dea | p@chr1:154940591..154940634, + |
| 5.38e-44 | FFCP PHASE2:Mm9::chr6:84135739..84135768,+#_343cb6382c7ce04c0b0223adb6fb5dea | p@chr6:84135739..84135768, + |
| 5.38e-44 | FFCP PHASE1:Mm9::chr6:84135739..84135768,+#_343cb6382c7ce04c0b0223adb6fb5dea | p@chr6:84135739..84135768, + |
| 5.38e-44 | FFCP PHASE2:Mm9::chr1:154940591..154940634,+#_343cb6382c7ce04c0b0223adb6fb5dea | p@chr1:154940591..154940634, + |
| 5.38e-44 | FFCP PHASE1:Mm9::chr12:86222392..86222395,-#_343cb6382c7ce04c0b0223adb6fb5dea | p@chr12:86222392..86222395, - |
| 5.38e-44 | FFCP PHASE1:Mm9::chr11:66340488..66340520,-#_343cb6382c7ce04c0b0223adb6fb5dea | p@chr11:66340488..66340520, - |
| 5.38e-44 | FFCP PHASE1:Mm9::chr11:45940767..45940771,+#_343cb6382c7ce04c0b0223adb6fb5dea | p@chr11:45940767..45940771, + |
| 5.38e-44 | FFCP PHASE2:Mm9::chr14:70592586..70592593,-#_343cb6382c7ce04c0b0223adb6fb5dea | p@chr14:70592586..70592593, - |
| 5.38e-44 | FFCP PHASE2:Mm9::chr11:66340488..66340520,-#_343cb6382c7ce04c0b0223adb6fb5dea | p@chr11:66340488..66340520, - |
| 5.38e-44 | FFCP PHASE1:Mm9::chr14:70592586..70592593,-#_343cb6382c7ce04c0b0223adb6fb5dea | p@chr14:70592586..70592593, - |
| 5.38e-44 | FFCP PHASE2:Mm9::chr12:86222392..86222395,-#_343cb6382c7ce04c0b0223adb6fb5dea | p@chr12:86222392..86222395, - |
| 5.38e-44 | FFCP PHASE2:Mm9::chr11:45940767..45940771,+#_343cb6382c7ce04c0b0223adb6fb5dea | p@chr11:45940767..45940771, + |
| 5.58e-44 | FFCP PHASE1:Mm9::chr1:72896186..72896195,+#_cab0a8fed99c6e1fdbd78c59983e3438 | p@chr1:72896186..72896195, + |
| 5.58e-44 | FFCP PHASE2:Mm9::chr1:72896186..72896195,+#_cab0a8fed99c6e1fdbd78c59983e3438 | p@chr1:72896186..72896195, + |
| 5.22e-43 | FFCP PHASE2:Hg19::chr12:41374792..41374806,+#_8ead371efe502c9edbc3f4c76f5c032e | p@chr12:41374792..41374806, + |
| 5.22e-43 | FFCP PHASE1:Hg19::chr12:41374792..41374806,+#_8ead371efe502c9edbc3f4c76f5c032e | p@chr12:41374792..41374806, + |
| 6.96e-43 | FFCP PHASE2:Hg19::chr11:60615014..60615025,+#_44c73a280fd3b67444d38630ad2261c3 | p8@CCDC86 |
| 6.96e-43 | FFCP PHASE1:Hg19::chr2:104096987..104096993,-#_44c73a280fd3b67444d38630ad2261c3 | p@chr2:104096987..104096993, - |
