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Coexpression cluster:C1633

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Full id: C1633_uterus_kidney_ovary_Hepatic_Mesothelial_Renal_spleen



Phase1 CAGE Peaks

Hg19::chr11:32456954..32456965,-p4@WT1
Hg19::chr11:32457075..32457095,-p1@WT1
Hg19::chr11:32457185..32457193,-p7@WT1
Hg19::chr11:32457307..32457323,+p4@WT1-AS
Hg19::chr11:32457350..32457361,+p5@WT1-AS


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>


Cell Type
Ontology termp-valuen
mesothelial cell1.75e-0919
cardiocyte1.18e-0716
Uber Anatomy
Ontology termp-valuen
compound organ8.13e-1469
body cavity precursor4.80e-1263
primary circulatory organ4.80e-1227
heart5.23e-1124
primitive heart tube5.23e-1124
primary heart field5.23e-1124
anterior lateral plate mesoderm5.23e-1124
heart tube5.23e-1124
heart primordium5.23e-1124
cardiac mesoderm5.23e-1124
cardiogenic plate5.23e-1124
heart rudiment5.23e-1124
reproductive structure3.06e-1059
reproductive system3.06e-1059
reproductive organ4.18e-1048
anatomical cavity4.78e-1070
gonad1.09e-0921
indifferent external genitalia1.09e-0921
indifferent gonad1.09e-0921
gonad primordium1.09e-0921
external genitalia5.71e-0922
body cavity or lining6.73e-0949
body cavity1.59e-0846
intermediate mesoderm3.77e-0837
anatomical space4.94e-08104
abdominal segment of trunk7.51e-0861
abdomen7.51e-0861
immaterial anatomical entity1.98e-07126
abdomen element2.16e-0755
abdominal segment element2.16e-0755
female gonad6.49e-0713
female reproductive organ8.42e-0737
female reproductive system8.42e-0737
Disease
Ontology termp-valuen
myeloid leukemia6.10e-2031
leukemia1.10e-1539
hematologic cancer3.23e-1051
immune system cancer3.23e-1051
disease of cellular proliferation1.12e-09239
ovarian cancer2.82e-0914
organ system cancer5.39e-09137
cancer3.05e-08235


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

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ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.