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MCL coexpression mm9:151

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Phase1 CAGE Peaks

 Short description
Mm9::chr10:117229719..117229773,-p1@Nup107
Mm9::chr10:127452242..127452287,+p1@Prim1
Mm9::chr10:127452290..127452305,+p2@Prim1
Mm9::chr10:127669128..127669150,+p1@LOC100504989
p1@Timeless
Mm9::chr10:20067594..20067665,+p1@Fam54a
Mm9::chr10:29920298..29920348,-p1@Cenpw
Mm9::chr10:29920353..29920379,-p2@Cenpw
Mm9::chr10:62409759..62409821,+p1@Dna2
Mm9::chr10:79317363..79317385,+p2@Ptbp1
Mm9::chr10:87609740..87609782,+p1@LOC634555
p1@Nup37
Mm9::chr11:120459660..120459719,-p1@Alyref
Mm9::chr12:107248485..107248549,+p1@Vrk1
Mm9::chr12:80398332..80398364,+p1@Rad51l1
Mm9::chr13:101545758..101545798,-p2@Cenph
Mm9::chr13:93125141..93125165,+p1@Dhfr
Mm9::chr13:93125167..93125172,+p5@Dhfr
Mm9::chr13:93125194..93125203,+p4@Dhfr
Mm9::chr15:102126687..102126761,+p1@Espl1
Mm9::chr15:54921977..54922051,-p1@Dscc1
Mm9::chr15:76470328..76470382,-p1@Tonsl
Mm9::chr15:76540916..76540941,-p1@Recql4
Mm9::chr16:23127775..23127819,-p1@Rfc4
Mm9::chr16:4719078..4719126,-p1@Nmral1
Mm9::chr16:93884140..93884199,+p1@Chaf1b
Mm9::chr17:46633702..46633758,+p1@BC048355
Mm9::chr17:56442819..56442841,+p2@Uhrf1
Mm9::chr17:56442850..56442890,+p1@Uhrf1
Mm9::chr19:39005438..39005458,+p1@Hells
Mm9::chr19:5964132..5964210,-p1@Pola2
Mm9::chr1:130256174..130256186,-p2@Mcm6
Mm9::chr1:130256187..130256275,-p1@Mcm6
Mm9::chr1:193399369..193399405,-p1@Dtl
Mm9::chr1:20810294..20810367,-p1@Mcm3
Mm9::chr1:33726573..33726584,-p3@Prim2
Mm9::chr1:95698417..95698522,-p1@Dtymk
Mm9::chr2:125073445..125073479,+p1@Dut
Mm9::chr2:132078910..132078953,-p1@Pcna
Mm9::chr2:150735301..150735378,+p1@Gins1
Mm9::chr2:156832751..156832774,-p3@Dsn1
Mm9::chr2:72314230..72314269,+p1@Cdca7
Mm9::chr2:84877326..84877362,+p2@Ssrp1
Mm9::chr3:32607592..32607660,+p1@Actl6a
Mm9::chr3:88214217..88214273,-p1@Pmf1
Mm9::chr4:115796223..115796300,-p1@Rad54l
Mm9::chr4:130037406..130037455,+p1@Snrnp40
Mm9::chr4:132324240..132324305,+p1@Rpa2
Mm9::chr4:24423581..24423646,+p1@Mms22l
Mm9::chr4:46463952..46463983,+p2@Anp32b
Mm9::chr4:46463990..46463998,+p4@Anp32b
Mm9::chr5:110715345..110715410,+p1@Pole
Mm9::chr5:138613050..138613061,-p3@Mcm7
Mm9::chr5:138613072..138613115,-p1@Mcm7
Mm9::chr5:149864614..149864629,-p1@Gm6115
p1@Hmgb1
p1@LOC637733
Mm9::chr5:149864636..149864647,-p4@Gm6115
p4@LOC637733
p5@Hmgb1
Mm9::chr5:151325174..151325212,+p2@Brca2
Mm9::chr5:152453731..152453788,-p1@Rfc3
Mm9::chr5:25211581..25211605,-p2@Xrcc2
Mm9::chr5:30400094..30400149,-p1@Tyms
Mm9::chr5:8422642..8422693,-p1@Dbf4
Mm9::chr7:137690787..137690864,-p1@Nsmce4a
Mm9::chr7:147222155..147222217,-p2@Tubgcp2
Mm9::chr7:31449960..31450003,-p1@Haus5
Mm9::chr7:51804120..51804203,-p1@Pold1
Mm9::chr8:125091901..125091920,+p2@Cdt1
Mm9::chr8:125091921..125091960,+p1@Cdt1
Mm9::chr8:77633458..77633500,+p1@Mcm5
Mm9::chr9:103207486..103207585,+p1@Topbp1
Mm9::chr9:107853283..107853322,+p1@Traip
Mm9::chr9:14589162..14589202,+p2@Mre11a
Mm9::chr9:21564719..21564738,-p1@Spc24
Mm9::chr9:21564742..21564760,-p2@Spc24
Mm9::chr9:64129382..64129437,+p1@Tipin
Mm9::chrX:7651696..7651752,-p1@Suv39h1


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


GO IDGO nameFDR corrected p-value
GO:0006259DNA metabolic process3.15330458288618e-29
GO:0006260DNA replication4.67286915465219e-28
GO:0005634nucleus3.02905470989514e-27
GO:0006139nucleobase, nucleoside, nucleotide and nucleic acid metabolic process5.40163738216021e-26
GO:0006261DNA-dependent DNA replication3.48768500926499e-15
GO:0006974response to DNA damage stimulus9.59888059389555e-14
GO:0043231intracellular membrane-bound organelle1.55523747148963e-13
GO:0043227membrane-bound organelle1.55523747148963e-13
GO:0009719response to endogenous stimulus1.9269433197973e-13
GO:0007049cell cycle4.51885055575174e-13
GO:0043283biopolymer metabolic process1.09120538839064e-12
GO:0006281DNA repair3.40935821279336e-12
GO:0043229intracellular organelle7.4759722734738e-12
GO:0043226organelle7.4759722734738e-12
GO:0022403cell cycle phase8.92273666493073e-12
GO:0008094DNA-dependent ATPase activity7.53249373032802e-11
GO:0003677DNA binding3.47431366316725e-10
GO:0044238primary metabolic process2.39384059447584e-09
GO:0044237cellular metabolic process2.6730337523508e-09
GO:0044424intracellular part4.58996025933372e-09
GO:0006270DNA replication initiation5.93370041819232e-09
GO:0000278mitotic cell cycle9.73059964308855e-09
GO:0043170macromolecule metabolic process1.20392958804383e-08
GO:0000279M phase1.20392958804383e-08
GO:0005622intracellular1.69463150750947e-08
GO:0022402cell cycle process3.8017592101679e-08
GO:0003676nucleic acid binding3.90710750470063e-08
GO:0005694chromosome4.41308356647323e-08
GO:0005657replication fork8.93675976906425e-08
GO:0006950response to stress1.1074446469447e-07
GO:0044427chromosomal part1.15929074018689e-07
GO:0016779nucleotidyltransferase activity2.34027870778727e-07
GO:0006310DNA recombination7.6252390310501e-07
GO:0000166nucleotide binding9.03616413698726e-07
GO:0005658alpha DNA polymerase:primase complex1.11408830143144e-06
GO:0007059chromosome segregation2.20925730743541e-06
GO:0042623ATPase activity, coupled2.20925730743541e-06
GO:0051301cell division2.90409136668118e-06
GO:0016462pyrophosphatase activity6.03470808329226e-06
GO:0016818hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides6.05610950206653e-06
GO:0016887ATPase activity6.05610950206653e-06
GO:0016817hydrolase activity, acting on acid anhydrides6.05610950206653e-06
GO:0051320S phase7.70946964792907e-06
GO:0000084S phase of mitotic cell cycle7.70946964792907e-06
GO:0003887DNA-directed DNA polymerase activity1.09039358986273e-05
GO:0043601nuclear replisome1.72548783175568e-05
GO:0030894replisome1.72548783175568e-05
GO:0000228nuclear chromosome2.31261049021504e-05
GO:0043596nuclear replication fork2.31261049021504e-05
GO:0017111nucleoside-triphosphatase activity2.92124400973089e-05
GO:0006275regulation of DNA replication3.0516357846238e-05
GO:0005524ATP binding3.38675536102417e-05
GO:0032559adenyl ribonucleotide binding3.82808823314224e-05
GO:0007067mitosis5.80047972604077e-05
GO:0000087M phase of mitotic cell cycle5.89438766237021e-05
GO:0030554adenyl nucleotide binding6.36289417617455e-05
GO:0019219regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process0.000155941073147859
GO:0006302double-strand break repair0.00017663550546281
GO:0007346regulation of progression through mitotic cell cycle0.00017663550546281
GO:0003896DNA primase activity0.000179382546341777
GO:0006350transcription0.00018759465755886
GO:0004386helicase activity0.000188673765015375
GO:0051052regulation of DNA metabolic process0.000190095688629298
GO:0010212response to ionizing radiation0.000190095688629298
GO:0019222regulation of metabolic process0.000199818676757546
GO:0044454nuclear chromosome part0.000249708036459689
GO:0016070RNA metabolic process0.000304170447340138
GO:0009219pyrimidine deoxyribonucleotide metabolic process0.000304170447340138
GO:0006269DNA replication, synthesis of RNA primer0.000304170447340138
GO:0006287base-excision repair, gap-filling0.000304170447340138
GO:0009221pyrimidine deoxyribonucleotide biosynthetic process0.000304170447340138
GO:0051327M phase of meiotic cell cycle0.000317638958272158
GO:0007126meiosis0.000317638958272158
GO:0032553ribonucleotide binding0.000322225484646875
GO:0032555purine ribonucleotide binding0.000322225484646875
GO:0051321meiotic cell cycle0.000322225484646875
GO:0016787hydrolase activity0.00036832978815441
GO:0051276chromosome organization and biogenesis0.000434618134789887
GO:0033261regulation of progression through S phase0.000434618134789887
GO:0009263deoxyribonucleotide biosynthetic process0.000434618134789887
GO:0007090regulation of S phase of mitotic cell cycle0.000434618134789887
GO:0017076purine nucleotide binding0.000447185330812165
GO:0044446intracellular organelle part0.000452490315714532
GO:0044422organelle part0.000476756506158463
GO:0031323regulation of cellular metabolic process0.000509064906395719
GO:0003899DNA-directed RNA polymerase activity0.000611674994291507
GO:0043232intracellular non-membrane-bound organelle0.00062545611014525
GO:0043228non-membrane-bound organelle0.00062545611014525
GO:0006338chromatin remodeling0.000764183637789637
GO:0051325interphase0.00101846235749989
GO:0051329interphase of mitotic cell cycle0.00101846235749989
GO:0000724double-strand break repair via homologous recombination0.00103935725970721
GO:0000725recombinational repair0.00103935725970721
GO:0008156negative regulation of DNA replication0.00103935725970721
GO:0001833inner cell mass cell proliferation0.00103935725970721
GO:0008283cell proliferation0.00124176142498293
GO:0016772transferase activity, transferring phosphorus-containing groups0.00124176142498293
GO:0044428nuclear part0.00125774878889427
GO:0006268DNA unwinding during replication0.00125774878889427
GO:0032508DNA duplex unwinding0.00125774878889427
GO:0032392DNA geometric change0.00125774878889427
GO:0032774RNA biosynthetic process0.00130999379615391
GO:0009262deoxyribonucleotide metabolic process0.00154009768440277
GO:0010165response to X-ray0.0018616474005412
GO:0001832blastocyst growth0.00255981425810372
GO:0006342chromatin silencing0.00255981425810372
GO:0031507heterochromatin formation0.00255981425810372
GO:0000775chromosome, pericentric region0.00280641356419977
GO:0051053negative regulation of DNA metabolic process0.00292845902660106
GO:0045814negative regulation of gene expression, epigenetic0.00334349102180072
GO:0010467gene expression0.00412730926283443
GO:0006284base-excision repair0.00424107610063794
GO:0006221pyrimidine nucleotide biosynthetic process0.0047221593430035
GO:0006220pyrimidine nucleotide metabolic process0.00516254453655152
GO:0003678DNA helicase activity0.00516254453655152
GO:0006730one-carbon compound metabolic process0.00516254453655152
GO:0031570DNA integrity checkpoint0.00555857942310869
GO:0016585chromatin remodeling complex0.00555857942310869
GO:0003697single-stranded DNA binding0.00555857942310869
GO:0009117nucleotide metabolic process0.00614601939436519
GO:0055086nucleobase, nucleoside and nucleotide metabolic process0.00785722532512364
GO:0016740transferase activity0.00787910142428621
GO:0009314response to radiation0.00839170878106891
GO:0000075cell cycle checkpoint0.0087002153863223
GO:0016458gene silencing0.0087002153863223
GO:0003682chromatin binding0.0087002153863223
GO:0007127meiosis I0.0087002153863223
GO:0006996organelle organization and biogenesis0.0087002153863223
GO:0042772DNA damage response, signal transduction resulting in transcription0.0087002153863223
GO:0031508centric heterochromatin formation0.0087002153863223
GO:0009177pyrimidine deoxyribonucleoside monophosphate biosynthetic process0.0087002153863223
GO:0009157deoxyribonucleoside monophosphate biosynthetic process0.0087002153863223
GO:0051171regulation of nitrogen compound metabolic process0.0087002153863223
GO:0051383kinetochore organization and biogenesis0.0087002153863223
GO:0043515kinetochore binding0.0087002153863223
GO:0009162deoxyribonucleoside monophosphate metabolic process0.0087002153863223
GO:0009176pyrimidine deoxyribonucleoside monophosphate metabolic process0.0087002153863223
GO:0006978DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator0.0087002153863223
GO:0004170dUTP diphosphatase activity0.0087002153863223
GO:0048478replication fork protection0.0087002153863223
GO:0006231dTMP biosynthetic process0.0087002153863223
GO:00420835,10-methylenetetrahydrofolate-dependent methyltransferase activity0.0087002153863223
GO:0045004DNA replication proofreading0.0087002153863223
GO:0019740nitrogen utilization0.0087002153863223
GO:0046073dTMP metabolic process0.0087002153863223
GO:0031055chromatin remodeling at centromere0.0087002153863223
GO:0006545glycine biosynthetic process0.0087002153863223
GO:0004799thymidylate synthase activity0.0087002153863223
GO:0006808regulation of nitrogen utilization0.0087002153863223
GO:0004146dihydrofolate reductase activity0.0087002153863223
GO:0043626PCNA complex0.0087002153863223
GO:0045875negative regulation of sister chromatid cohesion0.0087002153863223
GO:0030337DNA polymerase processivity factor activity0.0087002153863223
GO:0007063regulation of sister chromatid cohesion0.0087002153863223
GO:0006355regulation of transcription, DNA-dependent0.00880140301853096
GO:0045449regulation of transcription0.00932692971064166
GO:0050794regulation of cellular process0.00947024922444374
GO:0006351transcription, DNA-dependent0.00956051246705678
GO:0005635nuclear envelope0.00993403381199426
GO:0001824blastocyst development0.00994799621884025
GO:0000792heterochromatin0.0131324804534796
GO:0050789regulation of biological process0.0131324804534796
GO:0009165nucleotide biosynthetic process0.0135724520300108
GO:0016569covalent chromatin modification0.0136850101753674
GO:0045934negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process0.0150981133449953
GO:0009189deoxyribonucleoside diphosphate biosynthetic process0.0150981133449953
GO:0004798thymidylate kinase activity0.0150981133449953
GO:0009197pyrimidine deoxyribonucleoside diphosphate biosynthetic process0.0150981133449953
GO:0047429nucleoside-triphosphate diphosphatase activity0.0150981133449953
GO:0009196pyrimidine deoxyribonucleoside diphosphate metabolic process0.0150981133449953
GO:0006233dTDP biosynthetic process0.0150981133449953
GO:0009130pyrimidine nucleoside monophosphate biosynthetic process0.0150981133449953
GO:0009129pyrimidine nucleoside monophosphate metabolic process0.0150981133449953
GO:0009138pyrimidine nucleoside diphosphate metabolic process0.0150981133449953
GO:0010225response to UV-C0.0150981133449953
GO:0009139pyrimidine nucleoside diphosphate biosynthetic process0.0150981133449953
GO:0046072dTDP metabolic process0.0150981133449953
GO:0043414biopolymer methylation0.0162039160043243
GO:0040029regulation of gene expression, epigenetic0.0168730682349682
GO:0010468regulation of gene expression0.0172913426464061
GO:0032259methylation0.018140221160066
GO:0004527exonuclease activity0.018140221160066
GO:0051028mRNA transport0.0196343655688497
GO:0048589developmental growth0.0198511959057177
GO:0043566structure-specific DNA binding0.0198511959057177
GO:0009202deoxyribonucleoside triphosphate biosynthetic process0.0198511959057177
GO:0006235dTTP biosynthetic process0.0198511959057177
GO:0007141male meiosis I0.0198511959057177
GO:0000076DNA replication checkpoint0.0198511959057177
GO:0046075dTTP metabolic process0.0198511959057177
GO:0009211pyrimidine deoxyribonucleoside triphosphate metabolic process0.0198511959057177
GO:0010216maintenance of DNA methylation0.0198511959057177
GO:0009212pyrimidine deoxyribonucleoside triphosphate biosynthetic process0.0198511959057177
GO:0046125pyrimidine deoxyribonucleoside metabolic process0.0198511959057177
GO:0031573intra-S DNA damage checkpoint0.0198511959057177
GO:0000212meiotic spindle organization and biogenesis0.0198511959057177
GO:0032297negative regulation of DNA replication initiation0.0198511959057177
GO:0030174regulation of DNA replication initiation0.0198511959057177
GO:0045143homologous chromosome segregation0.0198511959057177
GO:0007089traversing start control point of mitotic cell cycle0.0198511959057177
GO:0009148pyrimidine nucleoside triphosphate biosynthetic process0.0198511959057177
GO:0051236establishment of RNA localization0.0198511959057177
GO:0050657nucleic acid transport0.0198511959057177
GO:0050658RNA transport0.0198511959057177
GO:0031324negative regulation of cellular metabolic process0.0198511959057177
GO:0006403RNA localization0.0202484670395594
GO:0005643nuclear pore0.0202484670395594
GO:0044464cell part0.0202484670395594
GO:0005623cell0.0202484670395594
GO:0016043cellular component organization and biogenesis0.0202484670395594
GO:0043234protein complex0.0202484670395594
GO:0065002intracellular protein transport across a membrane0.0222611536446463
GO:0015931nucleobase, nucleoside, nucleotide and nucleic acid transport0.0229557736592968
GO:0046930pore complex0.0235048772467655
GO:0016568chromatin modification0.0235048772467655
GO:0051567histone H3-K9 methylation0.0235048772467655
GO:0003689DNA clamp loader activity0.0235048772467655
GO:0033205cytokinesis during cell cycle0.0235048772467655
GO:0033170DNA-protein loading ATPase activity0.0235048772467655
GO:0009133nucleoside diphosphate biosynthetic process0.0235048772467655
GO:0009120deoxyribonucleoside metabolic process0.0235048772467655
GO:0009186deoxyribonucleoside diphosphate metabolic process0.0235048772467655
GO:0006346methylation-dependent chromatin silencing0.0235048772467655
GO:0005663DNA replication factor C complex0.0235048772467655
GO:0005721centric heterochromatin0.0235048772467655
GO:0045931positive regulation of progression through mitotic cell cycle0.0235048772467655
GO:0009628response to abiotic stimulus0.0235048772467655
GO:0044453nuclear membrane part0.0259789772887451
GO:0009892negative regulation of metabolic process0.0267945879902005
GO:0000074regulation of progression through cell cycle0.0271116267554325
GO:0031965nuclear membrane0.0272822106528812
GO:0000226microtubule cytoskeleton organization and biogenesis0.0279963129673401
GO:0001556oocyte maturation0.0283112397968595
GO:0009200deoxyribonucleoside triphosphate metabolic process0.0283112397968595
GO:0007062sister chromatid cohesion0.0283112397968595
GO:0000785chromatin0.032805469237265
GO:0065007biological regulation0.0328542136216438
GO:0000080G1 phase of mitotic cell cycle0.0331104184081896
GO:0009070serine family amino acid biosynthetic process0.0331104184081896
GO:0006213pyrimidine nucleoside metabolic process0.0331104184081896
GO:0051318G1 phase0.0331104184081896
GO:0000307cyclin-dependent protein kinase holoenzyme complex0.0381178251218692
GO:0007131meiotic recombination0.0381178251218692
GO:0045132meiotic chromosome segregation0.0381178251218692
GO:0032991macromolecular complex0.0383161317982588
GO:0006886intracellular protein transport0.0416380833161427
GO:0006544glycine metabolic process0.0420047285588263
GO:0048599oocyte development0.0420047285588263
GO:0010332response to gamma radiation0.0420047285588263
GO:0009994oocyte differentiation0.0420047285588263
GO:0005652nuclear lamina0.0420047285588263
GO:0005677chromatin silencing complex0.0420047285588263
GO:0004730pseudouridylate synthase activity0.0420047285588263
GO:0042771DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis0.0466557972357244
GO:0007140male meiosis0.0466557972357244
GO:0000922spindle pole0.0466557972357244



Relative expression of the co-expression cluster over median <br>Analyst:



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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>


Cell Type
Ontology termp-valuen

Uber Anatomy
Ontology termp-valuen

Disease
Ontology termp-valuen


TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs




JASPAR motifs


Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}