MCL coexpression mm9:1287

Phase1 CAGE Peaks

	Short description
Mm9::chr11:48805759..48805781,-	p3@Tgtp1 p3@Tgtp2
Mm9::chr2:167766298..167766302,+	p@chr2:167766298..167766302 +
Mm9::chr4:149075690..149075711,-	p2@Pik3cd
Mm9::chr5:122683421..122683445,+	p@chr5:122683421..122683445 +
Mm9::chr8:90812977..90812990,+	p8@Adcy7
Mm9::chrX:50113602..50113611,+	p@chrX:50113602..50113611 +

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0019932	second-messenger-mediated signaling	0.0041889307110198
GO:0046934	phosphatidylinositol-4,5-bisphosphate 3-kinase activity	0.0101825686755877
GO:0046854	phosphoinositide phosphorylation	0.0101825686755877
GO:0035004	phosphoinositide 3-kinase activity	0.0101825686755877
GO:0016303	1-phosphatidylinositol-3-kinase activity	0.0101825686755877
GO:0005942	phosphoinositide 3-kinase complex	0.0101825686755877
GO:0001782	B cell homeostasis	0.0101825686755877
GO:0046834	lipid phosphorylation	0.0101825686755877
GO:0004016	adenylate cyclase activity	0.0101825686755877
GO:0007190	adenylate cyclase activation	0.0101825686755877
GO:0031281	positive regulation of cyclase activity	0.0101825686755877
GO:0051349	positive regulation of lyase activity	0.0101825686755877
GO:0045762	positive regulation of adenylate cyclase activity	0.0101825686755877
GO:0045761	regulation of adenylate cyclase activity	0.0101825686755877
GO:0006171	cAMP biosynthetic process	0.0101825686755877
GO:0031279	regulation of cyclase activity	0.0101825686755877
GO:0051339	regulation of lyase activity	0.0101825686755877
GO:0002260	lymphocyte homeostasis	0.0101825686755877
GO:0046058	cAMP metabolic process	0.0101825686755877
GO:0001727	lipid kinase activity	0.0101825686755877
GO:0009975	cyclase activity	0.0101825686755877
GO:0016849	phosphorus-oxygen lyase activity	0.0101825686755877
GO:0030258	lipid modification	0.0101825686755877
GO:0001776	leukocyte homeostasis	0.0101825686755877
GO:0007242	intracellular signaling cascade	0.0101825686755877
GO:0009190	cyclic nucleotide biosynthetic process	0.0101825686755877
GO:0048872	homeostasis of number of cells	0.0101825686755877
GO:0004428	inositol or phosphatidylinositol kinase activity	0.0101825686755877
GO:0007189	G-protein signaling, adenylate cyclase activating pathway	0.0122869486827826
GO:0009187	cyclic nucleotide metabolic process	0.0125554027972597
GO:0048015	phosphoinositide-mediated signaling	0.0139948906204137
GO:0030384	phosphoinositide metabolic process	0.0139948906204137
GO:0007188	G-protein signaling, coupled to cAMP nucleotide second messenger	0.016860093186008
GO:0006650	glycerophospholipid metabolic process	0.016860093186008
GO:0007187	G-protein signaling, coupled to cyclic nucleotide second messenger	0.016860093186008
GO:0019933	cAMP-mediated signaling	0.0169560597719931
GO:0019935	cyclic-nucleotide-mediated signaling	0.0173212513502202
GO:0042113	B cell activation	0.0227412066789144
GO:0044445	cytosolic part	0.0244981950385326
GO:0006644	phospholipid metabolic process	0.0294582099803791
GO:0009165	nucleotide biosynthetic process	0.0302212702873356
GO:0043085	positive regulation of catalytic activity	0.0323928369149597
GO:0006643	membrane lipid metabolic process	0.0350565684588753
GO:0016829	lyase activity	0.0350565684588753
GO:0007166	cell surface receptor linked signal transduction	0.0374638801911031
GO:0009117	nucleotide metabolic process	0.0398981395349427
GO:0046649	lymphocyte activation	0.0407661960117566
GO:0055086	nucleobase, nucleoside and nucleotide metabolic process	0.040967261749857
GO:0045321	leukocyte activation	0.0425994543014596
GO:0001775	cell activation	0.0447688215167534

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>

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Cell Type

Ontology term	p-value	n

Uber Anatomy

Ontology term	p-value	n

Disease

Ontology term	p-value	n

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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