MCL coexpression mm9:116
From FANTOM5_SSTAR
Phase1 CAGE Peaks
Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data
| GO ID | GO name | FDR corrected p-value |
|---|---|---|
| GO:0007242 | intracellular signaling cascade | 0.000293664869207983 |
| GO:0030036 | actin cytoskeleton organization and biogenesis | 0.00402727299685778 |
| GO:0030029 | actin filament-based process | 0.00402727299685778 |
| GO:0002253 | activation of immune response | 0.0130000415564871 |
| GO:0003779 | actin binding | 0.0130000415564871 |
| GO:0008064 | regulation of actin polymerization and/or depolymerization | 0.0130000415564871 |
| GO:0030832 | regulation of actin filament length | 0.0130000415564871 |
| GO:0032535 | regulation of cellular component size | 0.0130000415564871 |
| GO:0032956 | regulation of actin cytoskeleton organization and biogenesis | 0.0130000415564871 |
| GO:0033043 | regulation of organelle organization and biogenesis | 0.0130000415564871 |
| GO:0051493 | regulation of cytoskeleton organization and biogenesis | 0.0130000415564871 |
| GO:0002757 | immune response-activating signal transduction | 0.0131962910207542 |
| GO:0002764 | immune response-regulating signal transduction | 0.0131962910207542 |
| GO:0050778 | positive regulation of immune response | 0.0131962910207542 |
| GO:0002684 | positive regulation of immune system process | 0.0131962910207542 |
| GO:0032760 | positive regulation of tumor necrosis factor production | 0.0131962910207542 |
| GO:0008154 | actin polymerization and/or depolymerization | 0.0131962910207542 |
| GO:0048518 | positive regulation of biological process | 0.0131962910207542 |
| GO:0032680 | regulation of tumor necrosis factor production | 0.0173595877607959 |
| GO:0030833 | regulation of actin filament polymerization | 0.0173595877607959 |
| GO:0050776 | regulation of immune response | 0.0173595877607959 |
| GO:0002682 | regulation of immune system process | 0.0177121463524503 |
| GO:0005525 | GTP binding | 0.0177121463524503 |
| GO:0051240 | positive regulation of multicellular organismal process | 0.0177121463524503 |
| GO:0007010 | cytoskeleton organization and biogenesis | 0.0177121463524503 |
| GO:0000165 | MAPKKK cascade | 0.0177121463524503 |
| GO:0019001 | guanyl nucleotide binding | 0.0177121463524503 |
| GO:0032561 | guanyl ribonucleotide binding | 0.0177121463524503 |
| GO:0051128 | regulation of cellular component organization and biogenesis | 0.0190686644568285 |
| GO:0008092 | cytoskeletal protein binding | 0.0190686644568285 |
| GO:0007264 | small GTPase mediated signal transduction | 0.0193338699831508 |
| GO:0009620 | response to fungus | 0.0195759985896822 |
| GO:0006911 | phagocytosis, engulfment | 0.0221005852117815 |
| GO:0030148 | sphingolipid biosynthetic process | 0.0239935659051621 |
| GO:0032640 | tumor necrosis factor production | 0.0239935659051621 |
| GO:0050764 | regulation of phagocytosis | 0.0258851381173991 |
| GO:0050766 | positive regulation of phagocytosis | 0.0258851381173991 |
| GO:0030041 | actin filament polymerization | 0.028505187330231 |
| GO:0046328 | regulation of JNK cascade | 0.0311812294906226 |
| GO:0001819 | positive regulation of cytokine production | 0.0359149485320526 |
| GO:0051091 | positive regulation of transcription factor activity | 0.0359149485320526 |
| GO:0031252 | leading edge | 0.0359149485320526 |
| GO:0051707 | response to other organism | 0.0359149485320526 |
| GO:0045807 | positive regulation of endocytosis | 0.0359149485320526 |
| GO:0007154 | cell communication | 0.0359149485320526 |
| GO:0032555 | purine ribonucleotide binding | 0.0359149485320526 |
| GO:0032553 | ribonucleotide binding | 0.0359149485320526 |
| GO:0007165 | signal transduction | 0.0359149485320526 |
| GO:0051090 | regulation of transcription factor activity | 0.0359149485320526 |
| GO:0046519 | sphingoid metabolic process | 0.0359149485320526 |
| GO:0033032 | regulation of myeloid cell apoptosis | 0.0359149485320526 |
| GO:0002720 | positive regulation of cytokine production during immune response | 0.0359149485320526 |
| GO:0005683 | snRNP U7 | 0.0359149485320526 |
| GO:0033028 | myeloid cell apoptosis | 0.0359149485320526 |
| GO:0003947 | (N-acetylneuraminyl)-galactosylglucosylceramide N-acetylgalactosaminyltransferase activity | 0.0359149485320526 |
| GO:0046329 | negative regulation of JNK cascade | 0.0359149485320526 |
| GO:0017050 | D-erythro-sphingosine kinase activity | 0.0359149485320526 |
| GO:0033025 | regulation of mast cell apoptosis | 0.0359149485320526 |
| GO:0006669 | sphinganine-1-phosphate biosynthetic process | 0.0359149485320526 |
| GO:0042989 | sequestering of actin monomers | 0.0359149485320526 |
| GO:0004796 | thromboxane-A synthase activity | 0.0359149485320526 |
| GO:0033024 | mast cell apoptosis | 0.0359149485320526 |
| GO:0033033 | negative regulation of myeloid cell apoptosis | 0.0359149485320526 |
| GO:0046511 | sphinganine biosynthetic process | 0.0359149485320526 |
| GO:0050861 | positive regulation of B cell receptor signaling pathway | 0.0359149485320526 |
| GO:0033026 | negative regulation of mast cell apoptosis | 0.0359149485320526 |
| GO:0050855 | regulation of B cell receptor signaling pathway | 0.0359149485320526 |
| GO:0032733 | positive regulation of interleukin-10 production | 0.0359149485320526 |
| GO:0033023 | mast cell homeostasis | 0.0359149485320526 |
| GO:0030837 | negative regulation of actin filament polymerization | 0.0359149485320526 |
| GO:0002431 | Fc receptor mediated stimulatory signaling pathway | 0.0359149485320526 |
| GO:0032765 | positive regulation of mast cell cytokine production | 0.0359149485320526 |
| GO:0002274 | myeloid leukocyte activation | 0.0370025197063896 |
| GO:0005925 | focal adhesion | 0.0370025197063896 |
| GO:0017076 | purine nucleotide binding | 0.0422581447772558 |
| GO:0001817 | regulation of cytokine production | 0.043598018268161 |
| GO:0007200 | G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) | 0.043598018268161 |
| GO:0000166 | nucleotide binding | 0.043598018268161 |
| GO:0005924 | cell-substrate adherens junction | 0.0455388806523591 |
| GO:0009607 | response to biotic stimulus | 0.0464925092721662 |
| GO:0002429 | immune response-activating cell surface receptor signaling pathway | 0.0472774236299305 |
| GO:0051050 | positive regulation of transport | 0.0496110103614133 |
Relative expression of the co-expression cluster over median <br>Analyst:
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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>
| Ontology term | p-value | n |
|---|
| Ontology term | p-value | n |
|---|
| Ontology term | p-value | n |
|---|
TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data
Novel motifs
JASPAR motifs
| Motifs | -log10(p-value) |
|---|---|
|
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