MCL coexpression mm9:405

Phase1 CAGE Peaks

	Short description
Mm9::chr13:12199124..12199135,-	p3@Ryr2
Mm9::chr13:12199136..12199148,-	p4@Ryr2
Mm9::chr13:12199242..12199251,-	p5@Ryr2
Mm9::chr15:99079365..99079378,-	p5@Mcrs1
Mm9::chr15:99079383..99079403,-	p2@Mcrs1
Mm9::chr16:4886302..4886320,+	p3@Mgrn1
Mm9::chr17:43938737..43938766,+	p4@Rcan2
Mm9::chr18:24867811..24867826,+	p4@Fhod3
Mm9::chr19:34736884..34736923,-	p1@Gm14446
Mm9::chr19:7061950..7062007,-	p2@Vegfb
Mm9::chr1:59030230..59030241,-	p7@Trak2
Mm9::chr2:55288199..55288212,+	p4@Kcnj3
Mm9::chr3:32716442..32716498,+	p4@Usp13
Mm9::chr5:122952145..122952154,-	p3@Atp2a2
Mm9::chr5:122952171..122952185,-	p2@Atp2a2
Mm9::chr5:122952636..122952663,-	p5@Atp2a2
Mm9::chr6:136499682..136499700,+	p@chr6:136499682..136499700 +
Mm9::chr7:36340444..36340532,-	p2@Nudt19
Mm9::chr8:86496850..86496927,+	p1@Prkaca

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0005218	intracellular ligand-gated calcium channel activity	0.0352514829974452
GO:0014074	response to purine	0.0352514829974452
GO:0005219	ryanodine-sensitive calcium-release channel activity	0.0352514829974452
GO:0031000	response to caffeine	0.0352514829974452
GO:0046873	metal ion transmembrane transporter activity	0.0352514829974452
GO:0004691	cAMP-dependent protein kinase activity	0.0471455207305244
GO:0030001	metal ion transport	0.0471455207305244
GO:0015467	G-protein activated inward rectifier potassium channel activity	0.0471455207305244
GO:0000209	protein polyubiquitination	0.0471455207305244
GO:0006816	calcium ion transport	0.0471455207305244
GO:0004690	cyclic nucleotide-dependent protein kinase activity	0.0471455207305244
GO:0015278	calcium-release channel activity	0.0471455207305244
GO:0050811	GABA receptor binding	0.0471455207305244
GO:0008324	cation transmembrane transporter activity	0.0471455207305244
GO:0006812	cation transport	0.0471455207305244
GO:0015674	di-, tri-valent inorganic cation transport	0.0499393897011789

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>

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Cell Type

Ontology term	p-value	n

Uber Anatomy

Ontology term	p-value	n

Disease

Ontology term	p-value	n

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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