MCL coexpression mm9:1611

Phase1 CAGE Peaks

	Short description
Mm9::chr12:103521071..103521081,+	p7@Rin3
Mm9::chr19:29436320..29436384,-	p1@5033414D02Rik
Mm9::chr1:87857604..87857648,-	p1@Gpr55
Mm9::chr4:133899797..133899824,+	p5@Slc30a2
Mm9::chr9:46036430..46036457,+	p4@Apoa1

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0043534	blood vessel endothelial cell migration	0.0211130385121345
GO:0008035	high-density lipoprotein binding	0.0211130385121345
GO:0033344	cholesterol efflux	0.0211130385121345
GO:0030300	regulation of cholesterol absorption	0.0211130385121345
GO:0030299	cholesterol absorption	0.0211130385121345
GO:0044241	lipid digestion	0.0211130385121345
GO:0051346	negative regulation of hydrolase activity	0.0211130385121345
GO:0017127	cholesterol transporter activity	0.0211130385121345
GO:0043542	endothelial cell migration	0.0211130385121345
GO:0015248	sterol transporter activity	0.0211130385121345
GO:0001935	endothelial cell proliferation	0.0211130385121345
GO:0050892	intestinal absorption	0.0211130385121345
GO:0008211	glucocorticoid metabolic process	0.0211130385121345
GO:0030325	adrenal gland development	0.0211130385121345
GO:0019915	sequestering of lipid	0.021892603712342
GO:0008034	lipoprotein binding	0.025103850034829
GO:0022600	digestive system process	0.025103850034829
GO:0030301	cholesterol transport	0.0255301778494967
GO:0015918	sterol transport	0.0259112507101296
GO:0006695	cholesterol biosynthetic process	0.03607532601436
GO:0016126	sterol biosynthetic process	0.0452546430490102

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>

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Cell Type

Ontology term	p-value	n

Uber Anatomy

Ontology term	p-value	n

Disease

Ontology term	p-value	n

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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