MCL coexpression mm9:707

Phase1 CAGE Peaks

	Short description
Mm9::chr11:34036959..34036965,+	p@chr11:34036959..34036965 +
Mm9::chr1:120524520..120524528,+	p1@Tfcp2l1
Mm9::chr4:138529156..138529170,+	p3@Tmco4
Mm9::chr4:19849701..19849719,-	p3@Atp6v0d2
Mm9::chr6:125271408..125271424,+	p4@Scnn1a
Mm9::chr7:51496594..51496610,-	p@chr7:51496594..51496610 -
Mm9::chr9:45211279..45211293,+	p3@Fxyd2
Mm9::chr9:45211310..45211324,+	p7@Fxyd2
Mm9::chr9:45211336..45211351,+	p5@Fxyd2
Mm9::chr9:45218158..45218182,-	p@chr9:45218158..45218182 -

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0015672	monovalent inorganic cation transport	0.00158039861051825
GO:0006812	cation transport	0.00325586580294328
GO:0031402	sodium ion binding	0.00347223247617122
GO:0015075	ion transmembrane transporter activity	0.00347223247617122
GO:0006811	ion transport	0.00347223247617122
GO:0006814	sodium ion transport	0.00347223247617122
GO:0022891	substrate-specific transmembrane transporter activity	0.00347223247617122
GO:0022857	transmembrane transporter activity	0.00470117197145586
GO:0022892	substrate-specific transporter activity	0.00547769025957714
GO:0031420	alkali metal ion binding	0.00581585755134062
GO:0015280	amiloride-sensitive sodium channel activity	0.0146354549967632
GO:0005216	ion channel activity	0.0170221709196813
GO:0022838	substrate specific channel activity	0.0170221709196813
GO:0022803	passive transmembrane transporter activity	0.0170221709196813
GO:0015267	channel activity	0.0170221709196813
GO:0030001	metal ion transport	0.0173381165054786
GO:0008324	cation transmembrane transporter activity	0.0223209777831049
GO:0005272	sodium channel activity	0.0299144025439421
GO:0015985	energy coupled proton transport, down electrochemical gradient	0.0299144025439421
GO:0015986	ATP synthesis coupled proton transport	0.0299144025439421
GO:0006810	transport	0.0299144025439421
GO:0051234	establishment of localization	0.0299144025439421
GO:0006754	ATP biosynthetic process	0.0299144025439421
GO:0006753	nucleoside phosphate metabolic process	0.0299144025439421
GO:0046933	hydrogen ion transporting ATP synthase activity, rotational mechanism	0.0299144025439421
GO:0016469	proton-transporting two-sector ATPase complex	0.0299144025439421
GO:0046961	hydrogen ion transporting ATPase activity, rotational mechanism	0.0299144025439421
GO:0046034	ATP metabolic process	0.0299144025439421
GO:0050909	sensory perception of taste	0.0299144025439421
GO:0009206	purine ribonucleoside triphosphate biosynthetic process	0.0299144025439421
GO:0009201	ribonucleoside triphosphate biosynthetic process	0.0299144025439421
GO:0009145	purine nucleoside triphosphate biosynthetic process	0.0299144025439421
GO:0019829	cation-transporting ATPase activity	0.0299144025439421
GO:0009142	nucleoside triphosphate biosynthetic process	0.0299144025439421
GO:0051179	localization	0.0299144025439421
GO:0009205	purine ribonucleoside triphosphate metabolic process	0.0299144025439421
GO:0009199	ribonucleoside triphosphate metabolic process	0.0299144025439421
GO:0009144	purine nucleoside triphosphate metabolic process	0.0299144025439421
GO:0006119	oxidative phosphorylation	0.0299144025439421
GO:0015992	proton transport	0.0299144025439421
GO:0006752	group transfer coenzyme metabolic process	0.0299144025439421
GO:0009141	nucleoside triphosphate metabolic process	0.0299144025439421
GO:0009152	purine ribonucleotide biosynthetic process	0.0299144025439421
GO:0006818	hydrogen transport	0.0299144025439421
GO:0044425	membrane part	0.0299144025439421
GO:0009260	ribonucleotide biosynthetic process	0.0303630143986193
GO:0009150	purine ribonucleotide metabolic process	0.030995750025988
GO:0006164	purine nucleotide biosynthetic process	0.030995750025988
GO:0009259	ribonucleotide metabolic process	0.0326853709778113
GO:0006163	purine nucleotide metabolic process	0.0338509070775254
GO:0042625	ATPase activity, coupled to transmembrane movement of ions	0.0351294593934611
GO:0009108	coenzyme biosynthetic process	0.0351294593934611
GO:0015276	ligand-gated ion channel activity	0.0351294593934611
GO:0022834	ligand-gated channel activity	0.0351294593934611
GO:0015078	hydrogen ion transmembrane transporter activity	0.0377902766736186
GO:0015077	monovalent inorganic cation transmembrane transporter activity	0.0384520175938953
GO:0051188	cofactor biosynthetic process	0.0384520175938953
GO:0046872	metal ion binding	0.0411519612016291
GO:0030955	potassium ion binding	0.0418827610497871
GO:0043167	ion binding	0.0418827610497871
GO:0042626	ATPase activity, coupled to transmembrane movement of substances	0.0418827610497871
GO:0043492	ATPase activity, coupled to movement of substances	0.0418827610497871
GO:0016820	hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances	0.0418827610497871
GO:0016020	membrane	0.0418827610497871
GO:0009165	nucleotide biosynthetic process	0.0427602571819404
GO:0015399	primary active transmembrane transporter activity	0.043502538955442
GO:0015405	P-P-bond-hydrolysis-driven transmembrane transporter activity	0.043502538955442
GO:0022890	inorganic cation transmembrane transporter activity	0.0438565654656228

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>

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Cell Type

Ontology term	p-value	n

Uber Anatomy

Ontology term	p-value	n

Disease

Ontology term	p-value	n

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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