MCL coexpression mm9:1375

Phase1 CAGE Peaks

	Short description
Mm9::chr15:78240169..78240178,+	p9@Mpst
Mm9::chr19:32669903..32669938,+	p5@Papss2
Mm9::chr3:98084350..98084367,+	p1@Hmgcs2
Mm9::chr7:133819942..133819953,-	p2@Sult1a1
Mm9::chr7:90780497..90780532,+	p1@Stard5
Mm9::chr8:120225837..120225856,+	p1@Hsd17b2

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0008202	steroid metabolic process	4.52099326239946e-06
GO:0006694	steroid biosynthetic process	4.71792564992609e-05
GO:0044255	cellular lipid metabolic process	0.000256852910400137
GO:0006629	lipid metabolic process	0.000335389894977196
GO:0008610	lipid biosynthetic process	0.000763104595152154
GO:0016782	transferase activity, transferring sulfur-containing groups	0.00174788185367212
GO:0016784	3-mercaptopyruvate sulfurtransferase activity	0.00432022915998153
GO:0004779	sulfate adenylyltransferase activity	0.00503957698138634
GO:0017067	tyrosine-ester sulfotransferase activity	0.00503957698138634
GO:0004781	sulfate adenylyltransferase (ATP) activity	0.00503957698138634
GO:0004421	hydroxymethylglutaryl-CoA synthase activity	0.00503957698138634
GO:0004020	adenylylsulfate kinase activity	0.00503957698138634
GO:0050327	testosterone 17-beta-dehydrogenase activity	0.00668680369197086
GO:0016740	transferase activity	0.00668680369197086
GO:0004062	aryl sulfotransferase activity	0.00671759538684697
GO:0006791	sulfur utilization	0.00671759538684697
GO:0004792	thiosulfate sulfurtransferase activity	0.00671759538684697
GO:0000103	sulfate assimilation	0.00671759538684697
GO:0016783	sulfurtransferase activity	0.00755625970617706
GO:0046912	transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer	0.00755625970617706
GO:0005743	mitochondrial inner membrane	0.00906493270344742
GO:0017127	cholesterol transporter activity	0.00906493270344742
GO:0015248	sterol transporter activity	0.00906493270344742
GO:0019866	organelle inner membrane	0.00906493270344742
GO:0004303	estradiol 17-beta-dehydrogenase activity	0.00906493270344742
GO:0015485	cholesterol binding	0.00906493270344742
GO:0031966	mitochondrial membrane	0.00906493270344742
GO:0005740	mitochondrial envelope	0.0101810170544678
GO:0008272	sulfate transport	0.0124949266956514
GO:0009058	biosynthetic process	0.012702024894884
GO:0044429	mitochondrial part	0.012702024894884
GO:0032934	sterol binding	0.0132071635044364
GO:0008299	isoprenoid biosynthetic process	0.0155449035455494
GO:0031975	envelope	0.0157144263002789
GO:0031967	organelle envelope	0.0157144263002789
GO:0016229	steroid dehydrogenase activity	0.0175926767312476
GO:0006695	cholesterol biosynthetic process	0.0179298479355187
GO:0006720	isoprenoid metabolic process	0.0224012732010386
GO:0016126	sterol biosynthetic process	0.0224012732010386
GO:0031090	organelle membrane	0.0260908927637333
GO:0008146	sulfotransferase activity	0.0322638411090593
GO:0005319	lipid transporter activity	0.0328471924877397
GO:0005496	steroid binding	0.0328471924877397
GO:0044237	cellular metabolic process	0.0397355137963694
GO:0006790	sulfur metabolic process	0.039997660765998
GO:0008203	cholesterol metabolic process	0.0417138401059138
GO:0016125	sterol metabolic process	0.0452483082324079
GO:0006869	lipid transport	0.0461587442985047

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>

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Cell Type

Ontology term	p-value	n

Uber Anatomy

Ontology term	p-value	n

Disease

Ontology term	p-value	n

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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