MCL coexpression mm9:2780

Phase1 CAGE Peaks

	Short description
Mm9::chr12:37040803..37040819,+	p1@Sostdc1
Mm9::chr15:75827192..75827208,+	p2@Mapk15
Mm9::chr3:87600860..87600904,+	p1@Insrr

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0007167	enzyme linked receptor protein signaling pathway	0.0318213003052409
GO:0030238	male sex determination	0.0318213003052409
GO:0004707	MAP kinase activity	0.0318213003052409
GO:0030514	negative regulation of BMP signaling pathway	0.0318213003052409
GO:0030510	regulation of BMP signaling pathway	0.0318213003052409
GO:0004672	protein kinase activity	0.0318213003052409
GO:0006468	protein amino acid phosphorylation	0.0318213003052409
GO:0007530	sex determination	0.0318213003052409
GO:0016773	phosphotransferase activity, alcohol group as acceptor	0.0318213003052409
GO:0016310	phosphorylation	0.0318213003052409
GO:0030509	BMP signaling pathway	0.03236398351419
GO:0006793	phosphorus metabolic process	0.03236398351419
GO:0006796	phosphate metabolic process	0.03236398351419
GO:0042475	odontogenesis of dentine-containing teeth	0.03236398351419
GO:0042476	odontogenesis	0.03236398351419
GO:0016301	kinase activity	0.03236398351419
GO:0004702	receptor signaling protein serine/threonine kinase activity	0.0368216120755673
GO:0016772	transferase activity, transferring phosphorus-containing groups	0.0374958029870282
GO:0004714	transmembrane receptor protein tyrosine kinase activity	0.0436345111195841
GO:0019199	transmembrane receptor protein kinase activity	0.0436345111195841
GO:0007178	transmembrane receptor protein serine/threonine kinase signaling pathway	0.0436345111195841
GO:0005524	ATP binding	0.0436345111195841
GO:0043687	post-translational protein modification	0.0436345111195841
GO:0032559	adenyl ribonucleotide binding	0.0436345111195841
GO:0005057	receptor signaling protein activity	0.0436345111195841
GO:0003006	reproductive developmental process	0.0436345111195841
GO:0030554	adenyl nucleotide binding	0.0436345111195841
GO:0009968	negative regulation of signal transduction	0.0436345111195841

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>

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Cell Type

Ontology term	p-value	n

Uber Anatomy

Ontology term	p-value	n

Disease

Ontology term	p-value	n

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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