MCL coexpression mm9:1088

Phase1 CAGE Peaks

	Short description
Mm9::chr11:73139974..73139980,-	p2@Aspa
Mm9::chr5:87995134..87995144,-	p@chr5:87995134..87995144 -
Mm9::chr5:87997964..87997976,-	p3@Sult1d1
Mm9::chr5:87997991..87998003,-	p4@Sult1d1
Mm9::chr5:87998007..87998027,-	p2@Sult1d1
Mm9::chrX:83021894..83021919,-	p2@Gyk
Mm9::chrX:83021945..83021982,-	p1@Gyk

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0009068	aspartate family amino acid catabolic process	0.00291129926721968
GO:0006533	aspartate catabolic process	0.00291129926721968
GO:0006083	acetate metabolic process	0.00291129926721968
GO:0017067	tyrosine-ester sulfotransferase activity	0.00291129926721968
GO:0019807	aspartoacylase activity	0.00291129926721968
GO:0004370	glycerol kinase activity	0.00291129926721968
GO:0006531	aspartate metabolic process	0.00291129926721968
GO:0004046	aminoacylase activity	0.00370488396178192
GO:0004062	aryl sulfotransferase activity	0.00370488396178192
GO:0006791	sulfur utilization	0.00370488396178192
GO:0000103	sulfate assimilation	0.00370488396178192
GO:0006072	glycerol-3-phosphate metabolic process	0.00509365721805264
GO:0009066	aspartate family amino acid metabolic process	0.0109661455256367
GO:0006071	glycerol metabolic process	0.0135726686781398
GO:0019751	polyol metabolic process	0.0135726686781398
GO:0008146	sulfotransferase activity	0.0270918119405119
GO:0009063	amino acid catabolic process	0.0270918119405119
GO:0016811	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	0.0270918119405119
GO:0016782	transferase activity, transferring sulfur-containing groups	0.0270918119405119
GO:0009310	amine catabolic process	0.0270918119405119
GO:0044270	nitrogen compound catabolic process	0.0270918119405119
GO:0006790	sulfur metabolic process	0.0277014569550259
GO:0016810	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	0.0396802049783122

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>

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Uber Anatomy

Ontology term	p-value	n
intestine	5.95e-17	31
gastrointestinal system	2.43e-15	47
digestive tract diverticulum	1.29e-12	23
sac	1.29e-12	23
digestive system	1.49e-12	116
digestive tract	1.49e-12	116
primitive gut	1.49e-12	116
endoderm-derived structure	1.50e-12	118
endoderm	1.50e-12	118
presumptive endoderm	1.50e-12	118
liver	4.65e-12	22
epithelial sac	4.65e-12	22
digestive gland	4.65e-12	22
epithelium of foregut-midgut junction	4.65e-12	22
anatomical boundary	4.65e-12	22
hepatobiliary system	4.65e-12	22
foregut-midgut junction	4.65e-12	22
hepatic diverticulum	4.65e-12	22
liver primordium	4.65e-12	22
septum transversum	4.65e-12	22
liver bud	4.65e-12	22
subdivision of digestive tract	1.45e-11	114
abdomen element	1.57e-10	49
abdominal segment element	1.57e-10	49
abdominal segment of trunk	1.57e-10	49
abdomen	1.57e-10	49
exocrine gland	9.15e-10	25
exocrine system	9.15e-10	25
mucosa	1.45e-08	15
subdivision of trunk	1.47e-07	66
intestinal mucosa	2.52e-07	13
anatomical wall	2.52e-07	13
wall of intestine	2.52e-07	13
gastrointestinal system mucosa	2.52e-07	13

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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