MCL coexpression mm9:1145

Phase1 CAGE Peaks

	Short description
Mm9::chr15:97923519..97923568,-	p3@Senp1
Mm9::chr3:95733202..95733221,+	p1@Anp32e
Mm9::chr5:140797478..140797539,-	p1@Mad1l1
Mm9::chr6:115803317..115803361,-	p2@Mbd4
Mm9::chr9:13631425..13631444,-	p3@Cep57
Mm9::chrX:39504179..39504196,+	p7@Stag2
Mm9::chrX:39504205..39504245,+	p2@Stag2

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0005634	nucleus	0.0141685794832761
GO:0016926	protein desumoylation	0.0314688884597356
GO:0017134	fibroblast growth factor binding	0.0314688884597356
GO:0007067	mitosis	0.0314688884597356
GO:0000087	M phase of mitotic cell cycle	0.0314688884597356
GO:0043231	intracellular membrane-bound organelle	0.0314688884597356
GO:0043227	membrane-bound organelle	0.0314688884597356
GO:0000278	mitotic cell cycle	0.0336934334272182
GO:0000279	M phase	0.0336934334272182
GO:0051301	cell division	0.0336934334272182
GO:0022403	cell cycle phase	0.0356650580745101
GO:0043229	intracellular organelle	0.0356650580745101
GO:0043226	organelle	0.0356650580745101
GO:0008543	fibroblast growth factor receptor signaling pathway	0.0411069134803286
GO:0006305	DNA alkylation	0.0411069134803286
GO:0006306	DNA methylation	0.0411069134803286
GO:0000060	protein import into nucleus, translocation	0.0411069134803286
GO:0008630	DNA damage response, signal transduction resulting in induction of apoptosis	0.0416724359350369
GO:0006284	base-excision repair	0.0416724359350369
GO:0006304	DNA modification	0.041911827250545
GO:0019212	phosphatase inhibitor activity	0.0421278127593552

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>

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Uber Anatomy

Ontology term	p-value	n
hemopoietic organ	2.01e-09	29
immune organ	2.01e-09	29
primordium	6.72e-09	134
anterior region of body	9.78e-08	43
hematopoietic system	1.44e-07	45
blood island	1.44e-07	45
hemolymphoid system	5.10e-07	48
immune system	5.10e-07	48

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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