MCL coexpression mm9:3396

Phase1 CAGE Peaks

	Short description
Mm9::chr3:142159888..142159903,+	p1@Gbp5
Mm9::chr3:142223502..142223533,+	p1@Gbp3
Mm9::chr3:142223536..142223566,+	p2@Gbp3

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0003924	GTPase activity	0.00123038084553368
GO:0005525	GTP binding	0.00174167029352057
GO:0032561	guanyl ribonucleotide binding	0.00174167029352057
GO:0019001	guanyl nucleotide binding	0.00174167029352057
GO:0017111	nucleoside-triphosphatase activity	0.00174167029352057
GO:0016462	pyrophosphatase activity	0.00174167029352057
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	0.00174167029352057
GO:0016817	hydrolase activity, acting on acid anhydrides	0.00174167029352057
GO:0006955	immune response	0.00174167029352057
GO:0002376	immune system process	0.00355407609452255
GO:0032555	purine ribonucleotide binding	0.0138596943531659
GO:0032553	ribonucleotide binding	0.0138596943531659
GO:0017076	purine nucleotide binding	0.0138596943531659
GO:0000166	nucleotide binding	0.0165051654322122
GO:0016787	hydrolase activity	0.0189943960889938

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

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Cell Type

Ontology term	p-value	n
hematopoietic cell	2.35e-08	32
hematopoietic oligopotent progenitor cell	2.35e-08	32
hematopoietic stem cell	2.35e-08	32
angioblastic mesenchymal cell	2.35e-08	32
hematopoietic multipotent progenitor cell	2.35e-08	32

Uber Anatomy

Ontology term	p-value	n
hemolymphoid system	1.65e-09	48
immune system	1.65e-09	48
hematopoietic system	5.46e-09	45
blood island	5.46e-09	45
adult organism	8.79e-09	51
mixed endoderm/mesoderm-derived structure	4.56e-08	35
lateral plate mesoderm	8.45e-08	87

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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