MCL coexpression mm9:442

Phase1 CAGE Peaks

	Short description
Mm9::chr11:61392754..61392766,-	p@chr11:61392754..61392766 -
Mm9::chr15:99230200..99230234,+	p@chr15:99230200..99230234 +
Mm9::chr16:95500961..95500974,+	p9@Kcnj15
Mm9::chr17:28654436..28654449,-	p6@Fkbp5
Mm9::chr17:28654454..28654503,-	p2@Fkbp5
Mm9::chr19:20567067..20567078,+	p6@E030003E18Rik
Mm9::chr19:20567096..20567107,+	p3@E030003E18Rik
Mm9::chr19:20567153..20567160,+	p7@E030003E18Rik
Mm9::chr19:20567168..20567179,+	p5@E030003E18Rik
Mm9::chr1:43198700..43198717,-	p@chr1:43198700..43198717 -
Mm9::chr1:74044459..74044466,-	p@chr1:74044459..74044466 -
Mm9::chr1:78813484..78813488,+	p1@Kcne4
Mm9::chr2:25256065..25256077,+	p3@Npdc1
Mm9::chr6:91222464..91222477,+	p@chr6:91222464..91222477 +
Mm9::chr8:11449034..11449045,+	p@chr8:11449034..11449045 +
Mm9::chr9:102766842..102766853,+	p@chr9:102766842..102766853 +
Mm9::chr9:21574473..21574490,-	p@chr9:21574473..21574490 -

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0005249	voltage-gated potassium channel activity	0.0122444119045219
GO:0030955	potassium ion binding	0.0122444119045219
GO:0022843	voltage-gated cation channel activity	0.0122444119045219
GO:0005267	potassium channel activity	0.0122444119045219
GO:0006813	potassium ion transport	0.0128416386282628
GO:0022832	voltage-gated channel activity	0.0128416386282628
GO:0005244	voltage-gated ion channel activity	0.0128416386282628
GO:0031420	alkali metal ion binding	0.0128416386282628
GO:0016505	apoptotic protease activator activity	0.0190961456510468
GO:0005261	cation channel activity	0.0190961456510468
GO:0022836	gated channel activity	0.0198529700108855
GO:0046873	metal ion transmembrane transporter activity	0.0204301555929285
GO:0015672	monovalent inorganic cation transport	0.0204301555929285
GO:0016504	protease activator activity	0.0223896866406807
GO:0005216	ion channel activity	0.0223896866406807
GO:0022838	substrate specific channel activity	0.0223896866406807
GO:0005242	inward rectifier potassium channel activity	0.0223896866406807
GO:0030693	caspase activity	0.0223896866406807
GO:0022803	passive transmembrane transporter activity	0.0223896866406807
GO:0015267	channel activity	0.0223896866406807
GO:0030001	metal ion transport	0.0231536167857767
GO:0008324	cation transmembrane transporter activity	0.029217087446526
GO:0006812	cation transport	0.029217087446526
GO:0043281	regulation of caspase activity	0.0394981256273736
GO:0003755	peptidyl-prolyl cis-trans isomerase activity	0.0411462600089206
GO:0016859	cis-trans isomerase activity	0.0411462600089206
GO:0015075	ion transmembrane transporter activity	0.0446302359362335

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

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Cell Type

Ontology term	p-value	n
muscle precursor cell	7.78e-07	6
contractile cell	7.78e-07	6
muscle cell	7.78e-07	6
myoblast	7.78e-07	6

Uber Anatomy

Ontology term	p-value	n
cardiovascular system	1.76e-08	23
circulatory system	1.76e-08	23
primary circulatory organ	5.05e-07	18
heart	5.05e-07	18
primitive heart tube	5.05e-07	18
primary heart field	5.05e-07	18
anterior lateral plate mesoderm	5.05e-07	18
heart tube	5.05e-07	18
heart primordium	5.05e-07	18
cardiac mesoderm	5.05e-07	18
cardiogenic plate	5.05e-07	18
heart rudiment	5.05e-07	18

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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