MCL coexpression mm9:63
From FANTOM5_SSTAR
Phase1 CAGE Peaks
Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data
| GO ID | GO name | FDR corrected p-value |
|---|---|---|
| GO:0009605 | response to external stimulus | 0.00215457038933645 |
| GO:0006955 | immune response | 0.00215457038933645 |
| GO:0002376 | immune system process | 0.00372281790332076 |
| GO:0005529 | sugar binding | 0.00444509241888022 |
| GO:0005515 | protein binding | 0.00444509241888022 |
| GO:0008009 | chemokine activity | 0.00444509241888022 |
| GO:0042330 | taxis | 0.00444509241888022 |
| GO:0006935 | chemotaxis | 0.00444509241888022 |
| GO:0007626 | locomotory behavior | 0.00444509241888022 |
| GO:0042379 | chemokine receptor binding | 0.00444509241888022 |
| GO:0006954 | inflammatory response | 0.00451380343676688 |
| GO:0005125 | cytokine activity | 0.00473078044212999 |
| GO:0009891 | positive regulation of biosynthetic process | 0.0092813358774555 |
| GO:0001664 | G-protein-coupled receptor binding | 0.00962256695363191 |
| GO:0030246 | carbohydrate binding | 0.0102499229371477 |
| GO:0005537 | mannose binding | 0.0108580011413837 |
| GO:0009611 | response to wounding | 0.0132571087858662 |
| GO:0019955 | cytokine binding | 0.01341970132435 |
| GO:0007610 | behavior | 0.0170790510750915 |
| GO:0048535 | lymph node development | 0.0177755666628 |
| GO:0005615 | extracellular space | 0.0203710452660301 |
| GO:0048029 | monosaccharide binding | 0.0248143839806163 |
| GO:0009893 | positive regulation of metabolic process | 0.0276989780174291 |
| GO:0044421 | extracellular region part | 0.0276989780174291 |
| GO:0001816 | cytokine production | 0.0276989780174291 |
| GO:0019956 | chemokine binding | 0.0276989780174291 |
| GO:0001637 | G-protein chemoattractant receptor activity | 0.0276989780174291 |
| GO:0004950 | chemokine receptor activity | 0.0276989780174291 |
| GO:0005102 | receptor binding | 0.032902505736339 |
| GO:0065007 | biological regulation | 0.0337879744842508 |
| GO:0032394 | MHC class Ib receptor activity | 0.0373504014203621 |
| GO:0030338 | CMP-N-acetylneuraminate monooxygenase activity | 0.0373504014203621 |
| GO:0042221 | response to chemical stimulus | 0.0373504014203621 |
| GO:0042108 | positive regulation of cytokine biosynthetic process | 0.0373504014203621 |
| GO:0048468 | cell development | 0.0392665570293052 |
| GO:0007249 | I-kappaB kinase/NF-kappaB cascade | 0.0421409933295321 |
| GO:0006952 | defense response | 0.0479913544783807 |
| GO:0009897 | external side of plasma membrane | 0.0479913544783807 |
| GO:0045727 | positive regulation of translation | 0.0479913544783807 |
| GO:0031328 | positive regulation of cellular biosynthetic process | 0.0479913544783807 |
| GO:0008037 | cell recognition | 0.0479913544783807 |
| GO:0032608 | interferon-beta production | 0.0479913544783807 |
| GO:0046381 | CMP-N-acetylneuraminate metabolic process | 0.0479913544783807 |
| GO:0047485 | protein N-terminus binding | 0.0479913544783807 |
| GO:0045357 | regulation of interferon-beta biosynthetic process | 0.0479913544783807 |
| GO:0016046 | detection of fungus | 0.0479913544783807 |
| GO:0045359 | positive regulation of interferon-beta biosynthetic process | 0.0479913544783807 |
| GO:0002223 | stimulatory C-type lectin receptor signaling pathway | 0.0479913544783807 |
| GO:0016716 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen | 0.0479913544783807 |
| GO:0050973 | detection of mechanical stimulus during equilibrioception | 0.0479913544783807 |
| GO:0045350 | interferon-beta biosynthetic process | 0.0479913544783807 |
| GO:0001879 | detection of yeast | 0.0479913544783807 |
| GO:0048522 | positive regulation of cellular process | 0.0481398165543465 |
| GO:0004872 | receptor activity | 0.0485393982646544 |
| GO:0009889 | regulation of biosynthetic process | 0.0488526161048061 |
Relative expression of the co-expression cluster over median <br>Analyst:
Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>
| Ontology term | p-value | n |
|---|---|---|
| megakaryocyte progenitor cell | 3.80e-11 | 6 |
| megakaryocyte | 3.80e-11 | 6 |
| megakaryocyte-erythroid progenitor cell | 2.89e-07 | 9 |
| Ontology term | p-value | n |
|---|---|---|
| hemolymphoid system | 3.32e-14 | 48 |
| immune system | 3.32e-14 | 48 |
| hematopoietic system | 2.37e-10 | 45 |
| blood island | 2.37e-10 | 45 |
| lymphoid system | 3.24e-08 | 3 |
| hemopoietic organ | 1.17e-07 | 29 |
| immune organ | 1.17e-07 | 29 |
| spleen | 2.94e-07 | 6 |
| cavity lining | 2.94e-07 | 6 |
| serous membrane | 2.94e-07 | 6 |
| gastrointestinal system mesentery | 2.94e-07 | 6 |
| stomach region | 2.94e-07 | 6 |
| mesentery | 2.94e-07 | 6 |
| gastrointestinal system serosa | 2.94e-07 | 6 |
| mesentery of stomach | 2.94e-07 | 6 |
| gut mesentery | 2.94e-07 | 6 |
| dorsal mesentery | 2.94e-07 | 6 |
| dorsal mesogastrium | 2.94e-07 | 6 |
| peritoneal cavity | 2.94e-07 | 6 |
| spleen primordium | 2.94e-07 | 6 |
| mixed endoderm/mesoderm-derived structure | 3.77e-07 | 35 |
TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data
Novel motifs
JASPAR motifs
| Motifs | -log10(p-value) |
|---|---|
|
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