MCL coexpression mm9:772

Phase1 CAGE Peaks

	Short description
Mm9::chr11:100939677..100939722,+	p1@Hsd17b1
Mm9::chr11:100939727..100939736,+	p3@Hsd17b1
Mm9::chr11:100939737..100939749,+	p2@Hsd17b1
Mm9::chr11:100939751..100939760,+	p4@Hsd17b1
Mm9::chr14:121173828..121173831,-	p@chr14:121173828..121173831 -
Mm9::chr14:24786370..24786382,-	p@chr14:24786370..24786382 -
Mm9::chr1:75503742..75503759,+	p2@Inha
Mm9::chr1:75503989..75504030,+	p@chr1:75503989..75504030 +
Mm9::chr8:67099288..67099296,-	p@chr8:67099288..67099296 -

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0006703	estrogen biosynthetic process	0.00635459742497994
GO:0008210	estrogen metabolic process	0.00635459742497994
GO:0004303	estradiol 17-beta-dehydrogenase activity	0.00847186806642716
GO:0016229	steroid dehydrogenase activity	0.0166730493051983
GO:0042446	hormone biosynthetic process	0.0228564951253319
GO:0006694	steroid biosynthetic process	0.0364738676396612
GO:0042445	hormone metabolic process	0.0366883263182712
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	0.0376907310028946
GO:0005179	hormone activity	0.0376907310028946
GO:0016614	oxidoreductase activity, acting on CH-OH group of donors	0.0376907310028946
GO:0008202	steroid metabolic process	0.0392947383329716
GO:0008083	growth factor activity	0.0392947383329716

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>

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Uber Anatomy

Ontology term	p-value	n
external genitalia	1.25e-42	17
indifferent external genitalia	1.25e-42	17
indifferent gonad	1.25e-42	17
testis	7.67e-42	14
gonad	3.14e-40	18
gonad primordium	3.14e-40	18
male reproductive organ	5.08e-39	15
male organism	1.50e-36	16
male reproductive system	1.50e-36	16
reproductive organ	5.11e-30	24
reproductive structure	1.17e-27	26
reproductive system	1.17e-27	26
body cavity	3.19e-19	37
body cavity or lining	3.19e-19	37
body cavity precursor	1.07e-18	38
anatomical cavity	3.38e-18	39
anatomical space	3.44e-12	57
immaterial anatomical entity	1.54e-08	79

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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