MCL coexpression mm9:109
From FANTOM5_SSTAR
Phase1 CAGE Peaks
Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data
| GO ID | GO name | FDR corrected p-value |
|---|---|---|
| GO:0008544 | epidermis development | 1.81681501959467e-11 |
| GO:0007398 | ectoderm development | 1.81681501959467e-11 |
| GO:0031424 | keratinization | 2.93978948384578e-11 |
| GO:0009913 | epidermal cell differentiation | 1.20221321138584e-10 |
| GO:0009888 | tissue development | 6.11320105929337e-10 |
| GO:0048730 | epidermis morphogenesis | 6.83697324301183e-10 |
| GO:0048729 | tissue morphogenesis | 8.28494904748731e-09 |
| GO:0005200 | structural constituent of cytoskeleton | 1.93321599581571e-08 |
| GO:0001533 | cornified envelope | 1.96932528023369e-07 |
| GO:0005856 | cytoskeleton | 5.04996550374379e-06 |
| GO:0005882 | intermediate filament | 5.04996550374379e-06 |
| GO:0045111 | intermediate filament cytoskeleton | 5.24804569852866e-06 |
| GO:0045104 | intermediate filament cytoskeleton organization and biogenesis | 1.94313949870611e-05 |
| GO:0045103 | intermediate filament-based process | 3.01822201922357e-05 |
| GO:0009653 | anatomical structure morphogenesis | 3.07882269222828e-05 |
| GO:0007566 | embryo implantation | 3.07882269222828e-05 |
| GO:0030216 | keratinocyte differentiation | 3.85283110982844e-05 |
| GO:0048513 | organ development | 0.000112838955055719 |
| GO:0042698 | menstrual cycle | 0.000189911441538527 |
| GO:0007565 | female pregnancy | 0.000194515263950349 |
| GO:0043232 | intracellular non-membrane-bound organelle | 0.000209565456599115 |
| GO:0043228 | non-membrane-bound organelle | 0.000209565456599115 |
| GO:0048731 | system development | 0.000485282087936337 |
| GO:0045109 | intermediate filament organization | 0.000538209729911624 |
| GO:0048609 | reproductive process in a multicellular organism | 0.000784637432670585 |
| GO:0032504 | multicellular organism reproduction | 0.000784637432670585 |
| GO:0007010 | cytoskeleton organization and biogenesis | 0.00133871346094242 |
| GO:0048856 | anatomical structure development | 0.00133871346094242 |
| GO:0044430 | cytoskeletal part | 0.00253027625670361 |
| GO:0007275 | multicellular organismal development | 0.00297855215607944 |
| GO:0004252 | serine-type endopeptidase activity | 0.0111596205801113 |
| GO:0017171 | serine hydrolase activity | 0.0127293657296882 |
| GO:0008236 | serine-type peptidase activity | 0.0127293657296882 |
| GO:0022414 | reproductive process | 0.013641497541815 |
| GO:0048869 | cellular developmental process | 0.0149771496123552 |
| GO:0030154 | cell differentiation | 0.0149771496123552 |
| GO:0014850 | response to muscle activity | 0.0149771496123552 |
| GO:0006089 | lactate metabolic process | 0.0149771496123552 |
| GO:0043618 | regulation of transcription from RNA polymerase II promoter in response to stress | 0.0149771496123552 |
| GO:0001632 | leukotriene B4 receptor activity | 0.0149771496123552 |
| GO:0051546 | keratinocyte migration | 0.0149771496123552 |
| GO:0014823 | response to activity | 0.0149771496123552 |
| GO:0043619 | regulation of transcription from RNA polymerase II promoter in response to oxidative stress | 0.0149771496123552 |
| GO:0051704 | multi-organism process | 0.0149771496123552 |
| GO:0032502 | developmental process | 0.0151098792328122 |
| GO:0043620 | regulation of transcription in response to stress | 0.0214357416666919 |
| GO:0042541 | hemoglobin biosynthetic process | 0.0262801076194385 |
| GO:0004974 | leukotriene receptor activity | 0.0262801076194385 |
| GO:0045095 | keratin filament | 0.0262801076194385 |
| GO:0030949 | positive regulation of vascular endothelial growth factor receptor signaling pathway | 0.0262801076194385 |
| GO:0030947 | regulation of vascular endothelial growth factor receptor signaling pathway | 0.0309737210561619 |
| GO:0045648 | positive regulation of erythrocyte differentiation | 0.0309737210561619 |
| GO:0020027 | hemoglobin metabolic process | 0.0309737210561619 |
| GO:0003810 | protein-glutamine gamma-glutamyltransferase activity | 0.035158035641484 |
| GO:0018149 | peptide cross-linking | 0.035158035641484 |
| GO:0035162 | embryonic hemopoiesis | 0.035158035641484 |
| GO:0006996 | organelle organization and biogenesis | 0.0356206582415915 |
| GO:0042562 | hormone binding | 0.0395816223221339 |
| GO:0002009 | morphogenesis of an epithelium | 0.0421669751630955 |
| GO:0009755 | hormone-mediated signaling | 0.0437043314293644 |
| GO:0046716 | muscle maintenance | 0.0475552861660067 |
| GO:0045646 | regulation of erythrocyte differentiation | 0.0475552861660067 |
Relative expression of the co-expression cluster over median <br>Analyst:
Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>
| Ontology term | p-value | n |
|---|---|---|
| zone of skin | 4.50e-21 | 5 |
| skin epidermis | 4.50e-21 | 5 |
| skin of body | 4.50e-21 | 5 |
| integument | 4.50e-21 | 5 |
| surface | 4.50e-21 | 5 |
| outer epithelium | 4.50e-21 | 5 |
| integumental system | 4.50e-21 | 5 |
| enveloping layer of ectoderm | 4.50e-21 | 5 |
| stomach | 8.39e-11 | 16 |
| food storage organ | 8.39e-11 | 16 |
| surface structure | 9.25e-11 | 22 |
| vagina | 1.56e-08 | 1 |
| tongue | 1.84e-08 | 1 |
| gustatory system | 1.84e-08 | 1 |
| future tongue | 1.84e-08 | 1 |
TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data
Novel motifs
JASPAR motifs
| Motifs | -log10(p-value) |
|---|---|
|
{{{tfbs_overrepresentation_jaspar}}} |
