MCL coexpression mm9:330

Phase1 CAGE Peaks

	Short description
Mm9::chr10:79482366..79482435,+	p3@Hmha1
Mm9::chr11:68505599..68505628,+	p1@Myh10
Mm9::chr14:32082684..32082746,-	p1@Dnahc1
Mm9::chr14:56472962..56473043,+	p1@Nynrin
Mm9::chr15:26825333..26825340,-	p2@Fbxl7
Mm9::chr17:46787557..46787583,+	p1@Cul7
Mm9::chr17:46787591..46787610,+	p2@Cul7
Mm9::chr2:152240475..152240491,-	p@chr2:152240475..152240491 -
Mm9::chr2:152240508..152240545,-	p1@Zcchc3
Mm9::chr2:152240554..152240570,-	p3@Zcchc3
Mm9::chr2:152240575..152240597,-	p2@Zcchc3
Mm9::chr2:153172121..153172156,-	p1@ENSMUST00000139636
Mm9::chr2:156665526..156665594,-	p1@ENSMUST00000134838 p1@ENSMUST00000137463
Mm9::chr3:46251861..46251902,-	p1@Pabpc4l
Mm9::chr5:37729838..37729858,+	p2@Evc2
Mm9::chr6:38249236..38249290,-	p1@Zc3hav1l
Mm9::chr6:48395825..48395846,-	p3@Zfp467
Mm9::chr7:25084406..25084425,-	p3@Zfp61
Mm9::chr7:69608158..69608162,-	p@chr7:69608158..69608162 -
Mm9::chr8:32297789..32297829,+	p1@Fut10
Mm9::chr8:87162861..87162916,+	p1@Cacna1a
Mm9::chr9:72772890..72772904,+	p@chr9:72772890..72772904 +
Mm9::chr9:8004414..8004436,-	p4@Yap1
Mm9::chrX:157600676..157600707,+	p1@Scml2

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0021680	cerebellar Purkinje cell layer development	0.0115143358490151
GO:0021695	cerebellar cortex development	0.0115143358490151
GO:0022037	metencephalon development	0.0115143358490151
GO:0021549	cerebellum development	0.0115143358490151
GO:0050885	neuromuscular process controlling balance	0.0138358327149211
GO:0030902	hindbrain development	0.0138358327149211
GO:0050905	neuromuscular process	0.0138358327149211
GO:0030425	dendrite	0.0138358327149211
GO:0050793	regulation of developmental process	0.0138358327149211
GO:0043025	cell soma	0.0138358327149211
GO:0021578	hindbrain maturation	0.0138358327149211
GO:0021548	pons development	0.0138358327149211
GO:0032353	negative regulation of hormone biosynthetic process	0.0138358327149211
GO:0006930	substrate-bound cell migration, cell extension	0.0138358327149211
GO:0048791	calcium ion-dependent exocytosis of neurotransmitter	0.0138358327149211
GO:0021626	central nervous system maturation	0.0138358327149211
GO:0021678	third ventricle development	0.0138358327149211
GO:0021592	fourth ventricle development	0.0138358327149211
GO:0032351	negative regulation of hormone metabolic process	0.0138358327149211
GO:0021679	cerebellar molecular layer development	0.0138358327149211
GO:0021590	cerebellum maturation	0.0138358327149211
GO:0021750	vestibular nucleus development	0.0138358327149211
GO:0044463	cell projection part	0.0177364098987912
GO:0046885	regulation of hormone biosynthetic process	0.0190185372696203
GO:0021591	ventricular system development	0.0190185372696203
GO:0021670	lateral ventricle development	0.0190185372696203
GO:0050883	musculoskeletal movement, spinal reflex action	0.0190185372696203
GO:0014056	regulation of acetylcholine secretion	0.0190185372696203
GO:0043531	ADP binding	0.0190185372696203
GO:0055015	ventricular cardiac muscle cell development	0.0190185372696203
GO:0014051	gamma-aminobutyric acid secretion	0.0190185372696203
GO:0014055	acetylcholine secretion	0.0190185372696203
GO:0006887	exocytosis	0.0192529709852802
GO:0042995	cell projection	0.0206118188554981
GO:0021700	developmental maturation	0.0207767562907057
GO:0030705	cytoskeleton-dependent intracellular transport	0.0217289218860015
GO:0055064	chloride ion homeostasis	0.0217289218860015
GO:0030644	cellular chloride ion homeostasis	0.0217289218860015
GO:0048857	neural nucleus development	0.0217289218860015
GO:0007097	nuclear migration	0.0217289218860015
GO:0032350	regulation of hormone metabolic process	0.0217289218860015
GO:0000281	cytokinesis after mitosis	0.0217289218860015
GO:0043005	neuron projection	0.0233933269220122
GO:0055083	monovalent inorganic anion homeostasis	0.0233933269220122
GO:0033205	cytokinesis during cell cycle	0.0233933269220122
GO:0055003	cardiac myofibril assembly	0.0233933269220122
GO:0017158	regulation of calcium ion-dependent exocytosis	0.0233933269220122
GO:0045601	regulation of endothelial cell differentiation	0.0233933269220122
GO:0030898	actin-dependent ATPase activity	0.0233933269220122
GO:0001778	plasma membrane repair	0.0233933269220122
GO:0060024	rhythmic synaptic transmission	0.0233933269220122
GO:0030320	cellular monovalent inorganic anion homeostasis	0.0233933269220122
GO:0050881	musculoskeletal movement	0.0266685637761362
GO:0006929	substrate-bound cell migration	0.0266685637761362
GO:0000146	microfilament motor activity	0.0266685637761362
GO:0048266	behavioral response to pain	0.0266685637761362
GO:0050879	multicellular organismal movement	0.0266685637761362
GO:0055012	ventricular cardiac muscle cell differentiation	0.0294125842816465
GO:0040023	establishment of nucleus localization	0.0294125842816465
GO:0055013	cardiac muscle cell development	0.0294125842816465
GO:0051647	nucleus localization	0.0294125842816465
GO:0008331	high voltage-gated calcium channel activity	0.0294125842816465
GO:0007409	axonogenesis	0.0324521622352901
GO:0055081	anion homeostasis	0.0327210672450276
GO:0030002	cellular anion homeostasis	0.0327210672450276
GO:0048667	neuron morphogenesis during differentiation	0.0340857635744828
GO:0048812	neurite morphogenesis	0.0340857635744828
GO:0060004	reflex	0.0357349363514642
GO:0045045	secretory pathway	0.0364386563812879
GO:0021692	cerebellar Purkinje cell layer morphogenesis	0.0364386563812879
GO:0035249	synaptic transmission, glutamatergic	0.0364386563812879
GO:0021694	cerebellar Purkinje cell layer formation	0.0364386563812879
GO:0007512	adult heart development	0.0364386563812879
GO:0060041	retina development in camera-type eye	0.0364386563812879
GO:0021702	cerebellar Purkinje cell differentiation	0.0364386563812879
GO:0007420	brain development	0.0370200017217645
GO:0000904	cellular morphogenesis during differentiation	0.0370200017217645
GO:0042403	thyroid hormone metabolic process	0.0370200017217645
GO:0043197	dendritic spine	0.0370200017217645
GO:0007009	plasma membrane organization and biogenesis	0.0370200017217645
GO:0045446	endothelial cell differentiation	0.0370200017217645
GO:0055007	cardiac muscle cell differentiation	0.0370200017217645
GO:0031175	neurite development	0.0383700978135761
GO:0043113	receptor clustering	0.0383700978135761
GO:0021697	cerebellar cortex formation	0.0383700978135761
GO:0021533	cell differentiation in hindbrain	0.0383700978135761
GO:0008417	fucosyltransferase activity	0.0383700978135761
GO:0032940	secretion by cell	0.0404508270494897
GO:0048265	response to pain	0.0404508270494897
GO:0005858	axonemal dynein complex	0.0404508270494897
GO:0031594	neuromuscular junction	0.0419443405874678
GO:0007274	neuromuscular synaptic transmission	0.0419443405874678
GO:0007172	signal complex assembly	0.0419443405874678
GO:0048813	dendrite morphogenesis	0.0419443405874678
GO:0048666	neuron development	0.0422104579164527
GO:0030239	myofibril assembly	0.042488017382512
GO:0005891	voltage-gated calcium channel complex	0.042488017382512
GO:0055002	striated muscle cell development	0.042488017382512
GO:0021696	cerebellar cortex morphogenesis	0.042488017382512
GO:0007417	central nervous system development	0.042488017382512
GO:0044447	axoneme part	0.042488017382512
GO:0021587	cerebellum morphogenesis	0.042488017382512
GO:0035051	cardiac cell differentiation	0.042488017382512
GO:0030427	site of polarized growth	0.042488017382512
GO:0030048	actin filament-based movement	0.042488017382512
GO:0030426	growth cone	0.042488017382512
GO:0055001	muscle cell development	0.042488017382512
GO:0051649	establishment of cellular localization	0.042488017382512
GO:0051641	cellular localization	0.0436779792210924
GO:0021575	hindbrain morphogenesis	0.0436779792210924
GO:0000096	sulfur amino acid metabolic process	0.0436779792210924
GO:0006950	response to stress	0.0451729903323541
GO:0007204	elevation of cytosolic calcium ion concentration	0.0451729903323541
GO:0051899	membrane depolarization	0.0451729903323541
GO:0007416	synaptogenesis	0.0465897799802007
GO:0046928	regulation of neurotransmitter secretion	0.0465897799802007
GO:0017157	regulation of exocytosis	0.0465897799802007
GO:0046903	secretion	0.0469226809493046
GO:0001725	stress fiber	0.0469226809493046
GO:0007214	gamma-aminobutyric acid signaling pathway	0.0469226809493046
GO:0031032	actomyosin structure organization and biogenesis	0.0469226809493046
GO:0051480	cytosolic calcium ion homeostasis	0.0469226809493046
GO:0032990	cell part morphogenesis	0.0469226809493046
GO:0048858	cell projection morphogenesis	0.0469226809493046
GO:0030030	cell projection organization and biogenesis	0.0469226809493046
GO:0017156	calcium ion-dependent exocytosis	0.0469226809493046
GO:0032432	actin filament bundle	0.0469226809493046
GO:0050804	regulation of synaptic transmission	0.0469226809493046
GO:0051969	regulation of transmission of nerve impulse	0.0469226809493046
GO:0030182	neuron differentiation	0.047772663659699
GO:0048628	myoblast maturation	0.047772663659699
GO:0051656	establishment of organelle localization	0.047772663659699
GO:0005245	voltage-gated calcium channel activity	0.047772663659699
GO:0005930	axoneme	0.048928832684291
GO:0007628	adult walking behavior	0.048928832684291
GO:0048627	myoblast development	0.048928832684291
GO:0015630	microtubule cytoskeleton	0.0491975845702045
GO:0043234	protein complex	0.0496764062639832
GO:0043524	negative regulation of neuron apoptosis	0.0496764062639832
GO:0021537	telencephalon development	0.0496764062639832

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>

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Uber Anatomy

Ontology term	p-value	n
multi-cellular organism	9.09e-09	333
embryo	4.06e-07	320

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
{{{tfbs_overrepresentation_jaspar}}}