MCL coexpression mm9:462

Phase1 CAGE Peaks

	Short description
Mm9::chr11:5688483..5688563,+	p1@Dbnl
Mm9::chr11:70465538..70465630,+	p@chr11:70465538..70465630 +
Mm9::chr16:37882681..37882733,+	p1@ENSMUST00000119947
Mm9::chr16:37883536..37883578,+	p@chr16:37883536..37883578 +
Mm9::chr2:164286445..164286518,+	p1@Sys1
Mm9::chr5:143665070..143665098,-	p@chr5:143665070..143665098 -
Mm9::chr5:143665205..143665254,-	p@chr5:143665205..143665254 -
Mm9::chr5:143665480..143665529,-	p@chr5:143665480..143665529 -
Mm9::chr5:143666062..143666094,-	p@chr5:143666062..143666094 -
Mm9::chr5:143666153..143666189,-	p@chr5:143666153..143666189 -
Mm9::chr5:143666379..143666429,+	p@chr5:143666379..143666429 +
Mm9::chr5:143666423..143666462,-	p@chr5:143666423..143666462 -
Mm9::chr5:143667058..143667080,-	p@chr5:143667058..143667080 -
Mm9::chr5:143668400..143668405,-	p1@Actb
Mm9::chr5:38918434..38918452,-	p@chr5:38918434..38918452 -
Mm9::chr6:113339103..113339107,+	p1@Ttll3

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0005856	cytoskeleton	0.0250868850449667
GO:0003779	actin binding	0.0250868850449667
GO:0005885	Arp2/3 protein complex	0.0250868850449667
GO:0043232	intracellular non-membrane-bound organelle	0.0250868850449667
GO:0043228	non-membrane-bound organelle	0.0250868850449667
GO:0008092	cytoskeletal protein binding	0.0250868850449667
GO:0042995	cell projection	0.0254891151896614
GO:0016601	Rac protein signal transduction	0.0316022499170498
GO:0030041	actin filament polymerization	0.0318311073828121
GO:0051015	actin filament binding	0.0404209655317858
GO:0005737	cytoplasm	0.0476799831454238
GO:0001726	ruffle	0.0476799831454238
GO:0051258	protein polymerization	0.0480569440756613
GO:0008154	actin polymerization and/or depolymerization	0.0480569440756613

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

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Cell Type

Ontology term	p-value	n
somatic cell	4.64e-24	118
animal cell	4.63e-22	115
eukaryotic cell	4.63e-22	115
stem cell	5.57e-16	97
somatic stem cell	6.27e-15	91
multi fate stem cell	6.27e-15	91
motile cell	1.10e-12	54
embryonic cell	7.01e-10	70
connective tissue cell	1.70e-09	46
mesenchymal cell	1.70e-09	46
non-terminally differentiated cell	1.85e-09	49
hematopoietic lineage restricted progenitor cell	5.66e-08	25
neural cell	3.03e-07	43
ectodermal cell	4.70e-07	44
neurectodermal cell	4.70e-07	44
leukocyte	6.26e-07	17
nongranular leukocyte	6.26e-07	17

Uber Anatomy

Ontology term	p-value	n
connective tissue	1.70e-09	46
hemolymphoid system	8.41e-08	48
immune system	8.41e-08	48
hematopoietic system	3.02e-07	45
blood island	3.02e-07	45

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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