MCL coexpression mm9:494

Phase1 CAGE Peaks

	Short description
Mm9::chr12:80081699..80081706,-	p15@Tmem229b
Mm9::chr13:56237443..56237448,-	p15@H2afy
Mm9::chr16:32179862..32179874,+	p2@Bex6
Mm9::chr16:32179880..32179921,+	p1@Bex6
Mm9::chr16:49857993..49858003,+	p@chr16:49857993..49858003 +
Mm9::chr16:92826016..92826027,-	p@chr16:92826016..92826027 -
Mm9::chr16:92826036..92826066,-	p@chr16:92826036..92826066 -
Mm9::chr3:135271325..135271343,-	p15@Nfkb1
Mm9::chr3:137660739..137660743,-	p@chr3:137660739..137660743 -
Mm9::chr3:51592897..51592913,+	p@chr3:51592897..51592913 +
Mm9::chr3:68495352..68495360,+	p3@Il12a
Mm9::chr8:82919099..82919104,-	p@chr8:82919099..82919104 -
Mm9::chr8:97544774..97544791,+	p@chr8:97544774..97544791 +
Mm9::chr8:97544803..97544843,+	p@chr8:97544803..97544843 +
Mm9::chrX:38753893..38753906,+	p6@Gria3

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

---

GO ID	GO name	FDR corrected p-value
GO:0042163	interleukin-12 beta subunit binding	0.0270640442666959
GO:0045083	negative regulation of interleukin-12 biosynthetic process	0.0270640442666959
GO:0005143	interleukin-12 receptor binding	0.0270640442666959
GO:0019972	interleukin-12 binding	0.0324724047235415
GO:0043514	interleukin-12 complex	0.0324724047235415
GO:0001740	Barr body	0.0391268735838529
GO:0002376	immune system process	0.0391268735838529
GO:0048266	behavioral response to pain	0.0411605921091782
GO:0035162	embryonic hemopoiesis	0.0411605921091782
GO:0000805	X chromosome	0.0411605921091782
GO:0042090	interleukin-12 biosynthetic process	0.0411605921091782
GO:0045766	positive regulation of angiogenesis	0.0411605921091782
GO:0045075	regulation of interleukin-12 biosynthetic process	0.0411605921091782
GO:0048534	hemopoietic or lymphoid organ development	0.0411605921091782
GO:0002520	immune system development	0.0441554987038445
GO:0007549	dosage compensation	0.045620555825299
GO:0042036	negative regulation of cytokine biosynthetic process	0.0463256521329975
GO:0032615	interleukin-12 production	0.0463256521329975
GO:0048265	response to pain	0.0463256521329975
GO:0016566	specific transcriptional repressor activity	0.0463256521329975
GO:0001739	sex chromatin	0.0463256521329975
GO:0000803	sex chromosome	0.0478983747889359

Relative expression of the co-expression cluster over median <br>Analyst:

---

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>

---

Uber Anatomy

Ontology term	p-value	n
hemolymphoid system	1.95e-18	48
immune system	1.95e-18	48
hemopoietic organ	5.30e-18	29
immune organ	5.30e-18	29
hematopoietic system	8.09e-18	45
blood island	8.09e-18	45
thymus	4.82e-15	23
neck	4.82e-15	23
respiratory system epithelium	4.82e-15	23
hemolymphoid system gland	4.82e-15	23
pharyngeal epithelium	4.82e-15	23
thymic region	4.82e-15	23
pharyngeal gland	4.82e-15	23
entire pharyngeal arch endoderm	4.82e-15	23
thymus primordium	4.82e-15	23
early pharyngeal endoderm	4.82e-15	23
mixed endoderm/mesoderm-derived structure	2.52e-14	35
pharynx	2.63e-14	24
gland of gut	2.63e-14	24
upper respiratory tract	2.63e-14	24
chordate pharynx	2.63e-14	24
pharyngeal arch system	2.63e-14	24
pharyngeal region of foregut	2.63e-14	24
segment of respiratory tract	2.01e-12	27
lateral plate mesoderm	2.30e-10	87
organ segment	5.44e-09	35
craniocervical region	1.14e-08	36
respiratory tract	2.63e-07	41
respiratory system	4.50e-07	42
anterior region of body	7.51e-07	43
gut epithelium	7.77e-07	55

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

---

Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
{{{tfbs_overrepresentation_jaspar}}}