MCL coexpression mm9:970

Phase1 CAGE Peaks

	Short description
Mm9::chr17:28995411..28995444,+	p1@Pnpla1
Mm9::chr2:24041989..24042004,+	p2@Il1f9
Mm9::chr4:43591403..43591433,-	p2@Gba2
Mm9::chr5:36895971..36896007,-	p@chr5:36895971..36896007 -
Mm9::chr6:115708992..115709018,-	p1@Tmem40
Mm9::chr6:86578183..86578202,+	p@chr6:86578183..86578202 +
Mm9::chr9:104240030..104240063,-	p1@Acpp
Mm9::chr9:111049199..111049228,+	p@chr9:111049199..111049228 +

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0004348	glucosylceramidase activity	0.0270780001081033
GO:0016787	hydrolase activity	0.0270780001081033
GO:0017040	ceramidase activity	0.0270780001081033
GO:0051605	protein maturation via proteolysis	0.0270780001081033
GO:0051604	protein maturation	0.0270780001081033
GO:0003993	acid phosphatase activity	0.0270780001081033
GO:0043588	skin development	0.0270780001081033
GO:0005149	interleukin-1 receptor binding	0.0270780001081033
GO:0004190	aspartic-type endopeptidase activity	0.036074342703912

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>

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Uber Anatomy

Ontology term	p-value	n
surface structure	4.77e-08	22
stomach	2.09e-07	16
food storage organ	2.09e-07	16

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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