MCL coexpression mm9:1064

Phase1 CAGE Peaks

	Short description
Mm9::chr11:121563707..121563718,+	p3@Metrnl
Mm9::chr11:121563732..121563748,+	p1@Metrnl
Mm9::chr11:121563767..121563781,+	p2@Metrnl
Mm9::chr19:4269140..4269200,-	p1@Ssh3
Mm9::chr2:160192793..160192809,-	p1@Mafb
Mm9::chr4:141430794..141430868,-	p1@Efhd2
Mm9::chr8:118231350..118231385,-	p7@Maf

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	0.0294313341529811
GO:0046983	protein dimerization activity	0.0294313341529811
GO:0045893	positive regulation of transcription, DNA-dependent	0.0294313341529811
GO:0045941	positive regulation of transcription	0.0294313341529811
GO:0045935	positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process	0.0294313341529811
GO:0007379	segment specification	0.0294313341529811
GO:0031325	positive regulation of cellular metabolic process	0.0294313341529811
GO:0009893	positive regulation of metabolic process	0.0294313341529811
GO:0006357	regulation of transcription from RNA polymerase II promoter	0.0294313341529811
GO:0006366	transcription from RNA polymerase II promoter	0.0304484986597984
GO:0043565	sequence-specific DNA binding	0.0304484986597984
GO:0007585	respiratory gaseous exchange	0.0363785067069221

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>

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Uber Anatomy

Ontology term	p-value	n
intestine	4.69e-13	31
gastrointestinal system	4.41e-11	47
mucosa	1.77e-08	15
intestinal mucosa	1.87e-07	13
anatomical wall	1.87e-07	13
wall of intestine	1.87e-07	13
gastrointestinal system mucosa	1.87e-07	13

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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