MCL coexpression mm9:2357

Phase1 CAGE Peaks

	Short description
Mm9::chr3:106903846..106903907,+	p@chr3:106903846..106903907 +
Mm9::chr5:138404139..138404159,-	p2@Gjc3
Mm9::chr9:48910825..48910857,+	p1@Tmprss5
Mm9::chr9:48916767..48916770,+	p2@Tmprss5

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0043209	myelin sheath	0.0215202749941214
GO:0005243	gap junction channel activity	0.0215202749941214
GO:0022829	wide pore channel activity	0.0215202749941214
GO:0005922	connexon complex	0.0215202749941214
GO:0005044	scavenger receptor activity	0.0215202749941214
GO:0005921	gap junction	0.0215202749941214
GO:0042552	myelination	0.0215202749941214
GO:0008366	axon ensheathment	0.0215202749941214
GO:0007272	ensheathment of neurons	0.0215202749941214
GO:0001508	regulation of action potential	0.0247057926010595
GO:0014704	intercalated disc	0.0273099945861852
GO:0007605	sensory perception of sound	0.049740520502399
GO:0050954	sensory perception of mechanical stimulus	0.049740520502399

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

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Cell Type

Ontology term	p-value	n
autonomic neuron	1.97e-07	9
neuron	9.86e-07	33
neuronal stem cell	9.86e-07	33
neuroblast	9.86e-07	33
electrically signaling cell	9.86e-07	33

Uber Anatomy

Ontology term	p-value	n
ectoderm-derived structure	1.18e-15	95
ectoderm	1.18e-15	95
presumptive ectoderm	1.18e-15	95
nervous system	1.88e-12	75
central nervous system	1.16e-11	73
ecto-epithelium	7.21e-11	73
neurectoderm	9.45e-09	64
neural plate	9.45e-09	64
presumptive neural plate	9.45e-09	64
multi-cellular organism	1.97e-08	333
peripheral nervous system	3.63e-08	11
structure with developmental contribution from neural crest	4.98e-08	92
autonomic nervous system	1.97e-07	9
regional part of nervous system	9.35e-07	54

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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