MCL coexpression mm9:261
From FANTOM5_SSTAR
Phase1 CAGE Peaks
Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data
GO ID | GO name | FDR corrected p-value |
---|---|---|
GO:0005381 | iron ion transmembrane transporter activity | 0.000456819144618196 |
GO:0051301 | cell division | 0.000733726995788518 |
GO:0016538 | cyclin-dependent protein kinase regulator activity | 0.0026114002127088 |
GO:0006873 | cellular ion homeostasis | 0.0026114002127088 |
GO:0055082 | cellular chemical homeostasis | 0.0026114002127088 |
GO:0006879 | cellular iron ion homeostasis | 0.0026114002127088 |
GO:0055072 | iron ion homeostasis | 0.0026114002127088 |
GO:0046915 | transition metal ion transmembrane transporter activity | 0.0026114002127088 |
GO:0050801 | ion homeostasis | 0.00265023647613552 |
GO:0015082 | di-, tri-valent inorganic cation transmembrane transporter activity | 0.00374559201860592 |
GO:0048878 | chemical homeostasis | 0.00404491782573569 |
GO:0019725 | cellular homeostasis | 0.00404491782573569 |
GO:0007049 | cell cycle | 0.00798705738009567 |
GO:0019887 | protein kinase regulator activity | 0.0081313237622078 |
GO:0048250 | mitochondrial iron ion transport | 0.0081313237622078 |
GO:0035229 | positive regulation of glutamate-cysteine ligase activity | 0.0081313237622078 |
GO:0035226 | glutamate-cysteine ligase catalytic subunit binding | 0.0081313237622078 |
GO:0035227 | regulation of glutamate-cysteine ligase activity | 0.0081313237622078 |
GO:0051351 | positive regulation of ligase activity | 0.0081313237622078 |
GO:0042592 | homeostatic process | 0.00854684043983682 |
GO:0019207 | kinase regulator activity | 0.00959426906029585 |
GO:0051882 | mitochondrial depolarization | 0.0106522111007838 |
GO:0016749 | N-succinyltransferase activity | 0.0106522111007838 |
GO:0004357 | glutamate-cysteine ligase activity | 0.0106522111007838 |
GO:0004998 | transferrin receptor activity | 0.0106522111007838 |
GO:0051340 | regulation of ligase activity | 0.0106522111007838 |
GO:0051900 | regulation of mitochondrial depolarization | 0.0106522111007838 |
GO:0017109 | glutamate-cysteine ligase complex | 0.0106522111007838 |
GO:0003870 | 5-aminolevulinate synthase activity | 0.0106522111007838 |
GO:0030005 | cellular di-, tri-valent inorganic cation homeostasis | 0.010902254789028 |
GO:0051188 | cofactor biosynthetic process | 0.010902254789028 |
GO:0055066 | di-, tri-valent inorganic cation homeostasis | 0.0110021371492729 |
GO:0030003 | cellular cation homeostasis | 0.0120011801332138 |
GO:0055080 | cation homeostasis | 0.0123224510919724 |
GO:0007144 | female meiosis I | 0.012520457965269 |
GO:0016748 | succinyltransferase activity | 0.012520457965269 |
GO:0051881 | regulation of mitochondrial membrane potential | 0.012520457965269 |
GO:0042541 | hemoglobin biosynthetic process | 0.0156168431581143 |
GO:0001940 | male pronucleus | 0.0156168431581143 |
GO:0022890 | inorganic cation transmembrane transporter activity | 0.0156168431581143 |
GO:0043085 | positive regulation of catalytic activity | 0.0159305284196433 |
GO:0001556 | oocyte maturation | 0.0171492062413345 |
GO:0020027 | hemoglobin metabolic process | 0.0171492062413345 |
GO:0001939 | female pronucleus | 0.0171492062413345 |
GO:0006534 | cysteine metabolic process | 0.0171492062413345 |
GO:0022402 | cell cycle process | 0.0172638545631914 |
GO:0006750 | glutathione biosynthetic process | 0.0196984864028533 |
GO:0007067 | mitosis | 0.0210190108072703 |
GO:0000087 | M phase of mitotic cell cycle | 0.0210190108072703 |
GO:0065008 | regulation of biological quality | 0.0210850417664668 |
GO:0048599 | oocyte development | 0.0232427130231152 |
GO:0009994 | oocyte differentiation | 0.0232427130231152 |
GO:0007143 | female meiosis | 0.0232427130231152 |
GO:0051186 | cofactor metabolic process | 0.0232427130231152 |
GO:0006783 | heme biosynthetic process | 0.0308229493562097 |
GO:0000278 | mitotic cell cycle | 0.0318412966535553 |
GO:0000279 | M phase | 0.0332048536694561 |
GO:0006779 | porphyrin biosynthetic process | 0.0339407523590761 |
GO:0033014 | tetrapyrrole biosynthetic process | 0.0339407523590761 |
GO:0045120 | pronucleus | 0.0359335298015824 |
GO:0065007 | biological regulation | 0.0388170245174001 |
GO:0000096 | sulfur amino acid metabolic process | 0.0390459646284324 |
GO:0042168 | heme metabolic process | 0.0390459646284324 |
GO:0050790 | regulation of catalytic activity | 0.0390459646284324 |
GO:0022403 | cell cycle phase | 0.0390459646284324 |
GO:0009069 | serine family amino acid metabolic process | 0.0390459646284324 |
GO:0051899 | membrane depolarization | 0.0390459646284324 |
GO:0033013 | tetrapyrrole metabolic process | 0.0400006848200994 |
GO:0006778 | porphyrin metabolic process | 0.0400006848200994 |
GO:0046873 | metal ion transmembrane transporter activity | 0.0400006848200994 |
GO:0006749 | glutathione metabolic process | 0.0411607496894537 |
GO:0048477 | oogenesis | 0.0448395069175333 |
GO:0065009 | regulation of a molecular function | 0.0456768811291409 |
GO:0006839 | mitochondrial transport | 0.0456938762583261 |
Relative expression of the co-expression cluster over median <br>Analyst:
Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>
Ontology term | p-value | n |
---|---|---|
subdivision of trunk | 3.94e-11 | 66 |
abdomen element | 1.42e-10 | 49 |
abdominal segment element | 1.42e-10 | 49 |
abdominal segment of trunk | 1.42e-10 | 49 |
abdomen | 1.42e-10 | 49 |
spleen | 1.10e-09 | 6 |
cavity lining | 1.10e-09 | 6 |
serous membrane | 1.10e-09 | 6 |
gastrointestinal system mesentery | 1.10e-09 | 6 |
stomach region | 1.10e-09 | 6 |
mesentery | 1.10e-09 | 6 |
gastrointestinal system serosa | 1.10e-09 | 6 |
mesentery of stomach | 1.10e-09 | 6 |
gut mesentery | 1.10e-09 | 6 |
dorsal mesentery | 1.10e-09 | 6 |
dorsal mesogastrium | 1.10e-09 | 6 |
peritoneal cavity | 1.10e-09 | 6 |
spleen primordium | 1.10e-09 | 6 |
foregut | 2.86e-09 | 80 |
trunk region element | 6.02e-08 | 79 |
intraembryonic coelom | 3.58e-07 | 10 |
TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data
Novel motifs
JASPAR motifs
Motifs | -log10(p-value) |
---|---|
MA0003.1 | 0.416392 |
MA0004.1 | 0.943038 |
MA0006.1 | 0.0915448 |
MA0007.1 | 0.0693451 |
MA0009.1 | 0.356735 |
MA0014.1 | 0.00558589 |
MA0017.1 | 0.11299 |
MA0019.1 | 0.221321 |
MA0024.1 | 0.322453 |
MA0025.1 | 0.553002 |
MA0027.1 | 1.91746 |
MA0028.1 | 0.0230932 |
MA0029.1 | 0.305809 |
MA0030.1 | 0.31081 |
MA0031.1 | 0.284004 |
MA0038.1 | 0.150331 |
MA0040.1 | 0.366712 |
MA0041.1 | 0.397031 |
MA0042.1 | 1.02922 |
MA0043.1 | 0.435645 |
MA0046.1 | 0.385571 |
MA0048.1 | 0.227772 |
MA0050.1 | 0.0934518 |
MA0051.1 | 0.155655 |
MA0052.1 | 0.974861 |
MA0055.1 | 2.01431 |
MA0056.1 | 0 |
MA0057.1 | 0.0493412 |
MA0058.1 | 0.358248 |
MA0059.1 | 0.168372 |
MA0060.1 | 0.00783438 |
MA0061.1 | 0.0572065 |
MA0063.1 | 0 |
MA0066.1 | 4.27173 |
MA0067.1 | 0.652366 |
MA0068.1 | 0.0532285 |
MA0069.1 | 0.373449 |
MA0070.1 | 0.365675 |
MA0071.1 | 0.310039 |
MA0072.1 | 0.358914 |
MA0073.1 | 0.000387491 |
MA0074.1 | 0.123701 |
MA0076.1 | 0.0318933 |
MA0077.1 | 0.341791 |
MA0078.1 | 0.521853 |
MA0081.1 | 0.192641 |
MA0083.1 | 1.10972 |
MA0084.1 | 0.958921 |
MA0087.1 | 1.03221 |
MA0088.1 | 0.269089 |
MA0089.1 | 0 |
MA0090.1 | 0.221633 |
MA0091.1 | 1.46918 |
MA0092.1 | 0.482591 |
MA0093.1 | 1.13914 |
MA0095.1 | 0 |
MA0098.1 | 0 |
MA0100.1 | 0.117472 |
MA0101.1 | 0.177595 |
MA0103.1 | 0.537896 |
MA0105.1 | 0.355784 |
MA0106.1 | 0.533809 |
MA0107.1 | 0.0280799 |
MA0108.2 | 0.237143 |
MA0109.1 | 0 |
MA0111.1 | 0.512045 |
MA0113.1 | 0.490789 |
MA0114.1 | 0.150918 |
MA0115.1 | 0.437985 |
MA0116.1 | 0.708546 |
MA0117.1 | 0.411186 |
MA0119.1 | 0.178209 |
MA0122.1 | 1.09377 |
MA0124.1 | 0.604388 |
MA0125.1 | 0.538769 |
MA0130.1 | 0 |
MA0131.1 | 0.218222 |
MA0132.1 | 0 |
MA0133.1 | 0 |
MA0135.1 | 0.466327 |
MA0136.1 | 0.419326 |
MA0139.1 | 0.180641 |
MA0140.1 | 0.117411 |
MA0141.1 | 0.327475 |
MA0142.1 | 0.27329 |
MA0143.1 | 0.515613 |
MA0144.1 | 1.1282 |
MA0145.1 | 0.451873 |
MA0146.1 | 0.0233321 |
MA0147.1 | 0.172105 |
MA0148.1 | 0.59177 |
MA0149.1 | 0.723587 |
MA0062.2 | 0.117118 |
MA0035.2 | 0.119926 |
MA0039.2 | 0.000458716 |
MA0138.2 | 0.212837 |
MA0002.2 | 0.336369 |
MA0137.2 | 0.322137 |
MA0104.2 | 0.379989 |
MA0047.2 | 0.149878 |
MA0112.2 | 0.451845 |
MA0065.2 | 0.310259 |
MA0150.1 | 0.522782 |
MA0151.1 | 0 |
MA0152.1 | 0.457674 |
MA0153.1 | 0.480495 |
MA0154.1 | 0.354879 |
MA0155.1 | 0.14685 |
MA0156.1 | 0.128979 |
MA0157.1 | 0.697652 |
MA0158.1 | 0 |
MA0159.1 | 0.0719173 |
MA0160.1 | 0.598518 |
MA0161.1 | 0 |
MA0162.1 | 0.111166 |
MA0163.1 | 0.0905096 |
MA0164.1 | 0.134941 |
MA0080.2 | 0.282578 |
MA0018.2 | 0.140467 |
MA0099.2 | 0.208596 |
MA0079.2 | 5.04018e-08 |
MA0102.2 | 1.0092 |
MA0258.1 | 0.273872 |
MA0259.1 | 0.0586005 |
MA0442.1 | 0 |