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MCL coexpression mm9:830

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Phase1 CAGE Peaks

 Short description
Mm9::chr16:10526522..10526533,+p@chr16:10526522..10526533
+
Mm9::chr17:34400169..34400201,+p1@H2-Ab1
Mm9::chr17:34401792..34401805,+p@chr17:34401792..34401805
+
Mm9::chr17:34404310..34404328,+p4@H2-Ab1
Mm9::chr17:34406063..34406072,+p@chr17:34406063..34406072
+
Mm9::chr17:34424715..34424775,-p1@H2-Aa
Mm9::chr18:60963511..60963522,+p2@Cd74
Mm9::chr18:60967650..60967694,+p@chr18:60967650..60967694
+
Mm9::chr18:60971536..60971571,-p@chr18:60971536..60971571
-


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

GO IDGO nameFDR corrected p-value
GO:0002495antigen processing and presentation of peptide antigen via MHC class II2.9402805329924e-08
GO:0019886antigen processing and presentation of exogenous peptide antigen via MHC class II2.9402805329924e-08
GO:0002478antigen processing and presentation of exogenous peptide antigen2.9402805329924e-08
GO:0002504antigen processing and presentation of peptide or polysaccharide antigen via MHC class II2.9402805329924e-08
GO:0019884antigen processing and presentation of exogenous antigen4.29906032935359e-08
GO:0048002antigen processing and presentation of peptide antigen1.21050145919687e-07
GO:0019882antigen processing and presentation5.07342523339865e-07
GO:0009897external side of plasma membrane6.22101460138392e-06
GO:0005771multivesicular body8.8585079378312e-06
GO:0042605peptide antigen binding1.05010597005964e-05
GO:0042613MHC class II protein complex1.05010597005964e-05
GO:0009986cell surface1.05010597005964e-05
GO:0045582positive regulation of T cell differentiation1.12422584331825e-05
GO:0045621positive regulation of lymphocyte differentiation1.66060611691512e-05
GO:0045580regulation of T cell differentiation2.00734155611001e-05
GO:0045619regulation of lymphocyte differentiation3.50008764403667e-05
GO:0005770late endosome4.31568247255248e-05
GO:0042611MHC protein complex4.31568247255248e-05
GO:0050870positive regulation of T cell activation0.000105122309886019
GO:0006955immune response0.000109084407774018
GO:0051251positive regulation of lymphocyte activation0.000183866701231306
GO:0030217T cell differentiation0.000183866701231306
GO:0050863regulation of T cell activation0.000187679693515391
GO:0002376immune system process0.000300639969246166
GO:0051249regulation of lymphocyte activation0.000300639969246166
GO:0050865regulation of cell activation0.000310449579595852
GO:0030098lymphocyte differentiation0.000342307974365833
GO:0003823antigen binding0.000489796968198964
GO:0042110T cell activation0.000525058165040789
GO:0002521leukocyte differentiation0.000588094545683921
GO:0042277peptide binding0.00059637262044293
GO:0005768endosome0.000930175800966296
GO:0005764lysosome0.000930175800966296
GO:0000323lytic vacuole0.000930175800966296
GO:0046649lymphocyte activation0.00106393407006628
GO:0005773vacuole0.00106393407006628
GO:0045581negative regulation of T cell differentiation0.00106393407006628
GO:0042289MHC class II protein binding0.00106393407006628
GO:0045321leukocyte activation0.00118324600739464
GO:0030097hemopoiesis0.00118324600739464
GO:0001775cell activation0.00130294059120673
GO:0048534hemopoietic or lymphoid organ development0.00140141979117727
GO:0045620negative regulation of lymphocyte differentiation0.00141025393779206
GO:0044459plasma membrane part0.00143080160803316
GO:0002520immune system development0.00150620481630705
GO:0051239regulation of multicellular organismal process0.00183547200533383
GO:0005886plasma membrane0.00288702999351992
GO:0045059positive thymic T cell selection0.00288702999351992
GO:0043368positive T cell selection0.00288702999351992
GO:0043383negative T cell selection0.00316989844716695
GO:0045060negative thymic T cell selection0.00316989844716695
GO:0042287MHC protein binding0.00388574769503132
GO:0051085chaperone cofactor-dependent protein folding0.00457441666176633
GO:0045061thymic T cell selection0.00505036483165125
GO:0006458'de novo' protein folding0.00505036483165125
GO:0051084'de novo' posttranslational protein folding0.00505036483165125
GO:0005794Golgi apparatus0.00579140002742289
GO:0045058T cell selection0.00592014396564938
GO:0050868negative regulation of T cell activation0.00616180615516501
GO:0005769early endosome0.00774007390611586
GO:0051250negative regulation of lymphocyte activation0.00814084023129064
GO:0033077T cell differentiation in the thymus0.00814084023129064
GO:0044444cytoplasmic part0.00917317022458876
GO:0016064immunoglobulin mediated immune response0.0219973520218007
GO:0019724B cell mediated immunity0.0219973520218007
GO:0002460adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains0.0267246294768124
GO:0002250adaptive immune response0.0267246294768124
GO:0048513organ development0.0268203057382782
GO:0002449lymphocyte mediated immunity0.0268203057382782
GO:0002443leukocyte mediated immunity0.0284377538866641
GO:0005515protein binding0.0305348782957564
GO:0006461protein complex assembly0.0347137540222794
GO:0043234protein complex0.0347137540222794
GO:0006457protein folding0.0352639211717114
GO:0002252immune effector process0.0361220354840267
GO:0048731system development0.0365256375817397
GO:0048869cellular developmental process0.0374692217593035
GO:0030154cell differentiation0.0374692217593035
GO:0005737cytoplasm0.0384030814579312
GO:0016021integral to membrane0.0454274553912678
GO:0031224intrinsic to membrane0.0454274553912678
GO:0048856anatomical structure development0.0455408651468514
GO:0032991macromolecular complex0.0477137550182854



Relative expression of the co-expression cluster over median <br>Analyst:




Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

Cell Type
Ontology termp-valuen
megakaryocyte progenitor cell2.77e-076
megakaryocyte2.77e-076


TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs




JASPAR motifs


Motifs-log10(p-value)
MA0003.10.170768
MA0004.10.394951
MA0006.10.670874
MA0007.10.991467
MA0009.11.92363
MA0014.10.00813637
MA0017.10.726051
MA0019.10.642876
MA0024.10.779446
MA0025.11.05446
MA0027.12.46647
MA0028.10.24786
MA0029.10.757957
MA0030.10.764448
MA0031.10.729293
MA0038.10.534262
MA0040.10.835181
MA0041.10.323687
MA0042.10.311486
MA0043.10.918718
MA0046.10.858391
MA0048.10.281053
MA0050.11.10321
MA0051.10.542972
MA0052.10.84317
MA0055.17.45031
MA0056.10
MA0057.10.0745664
MA0058.10.305206
MA0059.10.316585
MA0060.10.9744
MA0061.12.40227
MA0063.10
MA0066.10.523573
MA0067.11.16502
MA0068.10.077274
MA0069.10.843506
MA0070.10.833895
MA0071.10.431174
MA0072.11.92922
MA0073.10.00959692
MA0074.10.488775
MA0076.10.279739
MA0077.10.804033
MA0078.10.575205
MA0081.10.338098
MA0083.10.917931
MA0084.11.49188
MA0087.10.87515
MA0088.10.18495
MA0089.10
MA0090.10.362551
MA0091.11.04993
MA0092.10.362847
MA0093.10.2553
MA0095.10
MA0098.10
MA0100.10.477594
MA0101.10.867731
MA0103.10.748482
MA0105.12.3545
MA0106.10.582805
MA0107.12.89998
MA0108.20.665343
MA0109.10
MA0111.10.375908
MA0113.10.555251
MA0114.10.19245
MA0115.10.921497
MA0116.10.238371
MA0117.10.88947
MA0119.10.325434
MA0122.10.909168
MA0124.11.11203
MA0125.11.03833
MA0130.10
MA0131.10.638414
MA0132.10
MA0133.10
MA0135.10.954884
MA0136.10.508047
MA0139.11.39725
MA0140.10.477483
MA0141.10.29014
MA0142.10.714976
MA0143.10.571221
MA0144.10.195095
MA0145.10.77191
MA0146.10.30073
MA0147.10.593505
MA0148.10.410398
MA0149.10.330018
MA0062.20.113962
MA0035.20.482026
MA0039.20.043355
MA0138.20.630612
MA0002.20.447007
MA0137.20.287486
MA0104.20.476119
MA0047.20.533516
MA0112.20.442124
MA0065.20.200864
MA0150.10.380623
MA0151.10
MA0152.10.53362
MA0153.10.971406
MA0154.10.581988
MA0155.10.226288
MA0156.10.278949
MA0157.10.683365
MA0158.10
MA0159.10.614411
MA0160.10.413266
MA0161.10
MA0162.10.176565
MA0163.10.321031
MA0164.10.508398
MA0080.20.267388
MA0018.20.51781
MA0099.20.624421
MA0079.20.000240419
MA0102.21.5442
MA0258.11.61881
MA0259.10.571417
MA0442.10
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