MCL coexpression mm9:1455
From FANTOM5_SSTAR
Phase1 CAGE Peaks
Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data
| GO ID | GO name | FDR corrected p-value |
|---|---|---|
| GO:0005739 | mitochondrion | 0.00335232242348332 |
| GO:0006631 | fatty acid metabolic process | 0.00335232242348332 |
| GO:0032787 | monocarboxylic acid metabolic process | 0.00335232242348332 |
| GO:0005743 | mitochondrial inner membrane | 0.00335232242348332 |
| GO:0019866 | organelle inner membrane | 0.00335232242348332 |
| GO:0031966 | mitochondrial membrane | 0.00335232242348332 |
| GO:0005740 | mitochondrial envelope | 0.00335232242348332 |
| GO:0004095 | carnitine O-palmitoyltransferase activity | 0.00335232242348332 |
| GO:0003857 | 3-hydroxyacyl-CoA dehydrogenase activity | 0.00335232242348332 |
| GO:0016416 | O-palmitoyltransferase activity | 0.00335232242348332 |
| GO:0044429 | mitochondrial part | 0.00410810615792097 |
| GO:0016406 | carnitine O-acyltransferase activity | 0.0041899438406562 |
| GO:0031975 | envelope | 0.00453799157182207 |
| GO:0031967 | organelle envelope | 0.00453799157182207 |
| GO:0019752 | carboxylic acid metabolic process | 0.00565429891753072 |
| GO:0006082 | organic acid metabolic process | 0.00565429891753072 |
| GO:0044255 | cellular lipid metabolic process | 0.00661243880005698 |
| GO:0031090 | organelle membrane | 0.00661243880005698 |
| GO:0016409 | palmitoyltransferase activity | 0.00661243880005698 |
| GO:0006629 | lipid metabolic process | 0.007600041905139 |
| GO:0044444 | cytoplasmic part | 0.0114105288159519 |
| GO:0008374 | O-acyltransferase activity | 0.0114120987087785 |
| GO:0016616 | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor | 0.0396417957725654 |
| GO:0050662 | coenzyme binding | 0.0396417957725654 |
| GO:0016614 | oxidoreductase activity, acting on CH-OH group of donors | 0.0396417957725654 |
| GO:0005737 | cytoplasm | 0.0483821185722341 |
| GO:0048037 | cofactor binding | 0.0489670450367433 |
| GO:0008415 | acyltransferase activity | 0.0489670450367433 |
| GO:0016747 | transferase activity, transferring groups other than amino-acyl groups | 0.0489670450367433 |
| GO:0016746 | transferase activity, transferring acyl groups | 0.0492535389499352 |
Relative expression of the co-expression cluster over median <br>Analyst:
Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>
| Ontology term | p-value | n |
|---|---|---|
| intestine | 7.70e-13 | 31 |
| gastrointestinal system | 8.99e-10 | 47 |
| epithelial tube | 6.10e-09 | 47 |
| digestive tract diverticulum | 5.95e-08 | 23 |
| sac | 5.95e-08 | 23 |
| mucosa | 1.13e-07 | 15 |
| exocrine gland | 1.63e-07 | 25 |
| exocrine system | 1.63e-07 | 25 |
| liver | 1.90e-07 | 22 |
| epithelial sac | 1.90e-07 | 22 |
| digestive gland | 1.90e-07 | 22 |
| epithelium of foregut-midgut junction | 1.90e-07 | 22 |
| anatomical boundary | 1.90e-07 | 22 |
| hepatobiliary system | 1.90e-07 | 22 |
| foregut-midgut junction | 1.90e-07 | 22 |
| hepatic diverticulum | 1.90e-07 | 22 |
| liver primordium | 1.90e-07 | 22 |
| septum transversum | 1.90e-07 | 22 |
| liver bud | 1.90e-07 | 22 |
| intestinal mucosa | 8.62e-07 | 13 |
| anatomical wall | 8.62e-07 | 13 |
| wall of intestine | 8.62e-07 | 13 |
| gastrointestinal system mucosa | 8.62e-07 | 13 |
TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data
Novel motifs
JASPAR motifs
| Motifs | -log10(p-value) |
|---|---|
| MA0003.1 | 0.730824 |
| MA0004.1 | 0.536396 |
| MA0006.1 | 0.945134 |
| MA0007.1 | 0.52077 |
| MA0009.1 | 0.987341 |
| MA0014.1 | 0.883128 |
| MA0017.1 | 0.387481 |
| MA0019.1 | 0.800946 |
| MA0024.1 | 0.942716 |
| MA0025.1 | 1.22395 |
| MA0027.1 | 2.64231 |
| MA0028.1 | 2.59368 |
| MA0029.1 | 0.920529 |
| MA0030.1 | 0.927235 |
| MA0031.1 | 0.890871 |
| MA0038.1 | 0.686534 |
| MA0040.1 | 2.28622 |
| MA0041.1 | 0.457338 |
| MA0042.1 | 0.443591 |
| MA0043.1 | 1.08567 |
| MA0046.1 | 1.02391 |
| MA0048.1 | 0.486223 |
| MA0050.1 | 0.57678 |
| MA0051.1 | 0.695779 |
| MA0052.1 | 1.00829 |
| MA0055.1 | 1.22706 |
| MA0056.1 | 0 |
| MA0057.1 | 0.149949 |
| MA0058.1 | 0.436487 |
| MA0059.1 | 0.449345 |
| MA0060.1 | 0.757042 |
| MA0061.1 | 1.49922 |
| MA0063.1 | 0 |
| MA0066.1 | 0.675169 |
| MA0067.1 | 1.33603 |
| MA0068.1 | 0.467569 |
| MA0069.1 | 1.00864 |
| MA0070.1 | 0.998765 |
| MA0071.1 | 0.575909 |
| MA0072.1 | 0.990133 |
| MA0073.1 | 2.47041 |
| MA0074.1 | 1.54084 |
| MA0076.1 | 3.77832 |
| MA0077.1 | 0.968053 |
| MA0078.1 | 0.729877 |
| MA0081.1 | 0.473489 |
| MA0083.1 | 1.08487 |
| MA0084.1 | 1.66561 |
| MA0087.1 | 1.04109 |
| MA0088.1 | 0.358337 |
| MA0089.1 | 0 |
| MA0090.1 | 0.500693 |
| MA0091.1 | 0.55008 |
| MA0092.1 | 0.501022 |
| MA0093.1 | 0.379257 |
| MA0095.1 | 0 |
| MA0098.1 | 0 |
| MA0100.1 | 0.626021 |
| MA0101.1 | 0.458688 |
| MA0103.1 | 0.398766 |
| MA0105.1 | 1.09694 |
| MA0106.1 | 0.737893 |
| MA0107.1 | 1.79828 |
| MA0108.2 | 0.824407 |
| MA0109.1 | 0 |
| MA0111.1 | 0.515457 |
| MA0113.1 | 0.708789 |
| MA0114.1 | 0.822296 |
| MA0115.1 | 1.08851 |
| MA0116.1 | 0.359483 |
| MA0117.1 | 1.05576 |
| MA0119.1 | 0.459301 |
| MA0122.1 | 1.07591 |
| MA0124.1 | 1.28237 |
| MA0125.1 | 1.20757 |
| MA0130.1 | 0 |
| MA0131.1 | 0.796279 |
| MA0132.1 | 0 |
| MA0133.1 | 0 |
| MA0135.1 | 1.1226 |
| MA0136.1 | 0.658622 |
| MA0139.1 | 2.74529 |
| MA0140.1 | 0.625902 |
| MA0141.1 | 0.419361 |
| MA0142.1 | 0.876028 |
| MA0143.1 | 0.725672 |
| MA0144.1 | 1.502 |
| MA0145.1 | 0.119202 |
| MA0146.1 | 1.89206 |
| MA0147.1 | 0.320675 |
| MA0148.1 | 0.553294 |
| MA0149.1 | 0.464445 |
| MA0062.2 | 5.05991 |
| MA0035.2 | 0.630778 |
| MA0039.2 | 10.7159 |
| MA0138.2 | 0.788113 |
| MA0002.2 | 0.689262 |
| MA0137.2 | 1.88035 |
| MA0104.2 | 0.261255 |
| MA0047.2 | 0.685741 |
| MA0112.2 | 2.45463 |
| MA0065.2 | 1.24784 |
| MA0150.1 | 1.29346 |
| MA0151.1 | 0 |
| MA0152.1 | 0.685852 |
| MA0153.1 | 1.13945 |
| MA0154.1 | 0.933846 |
| MA0155.1 | 0.132921 |
| MA0156.1 | 1.84703 |
| MA0157.1 | 0.843181 |
| MA0158.1 | 0 |
| MA0159.1 | 0.881902 |
| MA0160.1 | 0.556423 |
| MA0161.1 | 0 |
| MA0162.1 | 4.55334 |
| MA0163.1 | 0.372305 |
| MA0164.1 | 0.658997 |
| MA0080.2 | 0.393257 |
| MA0018.2 | 0.669032 |
| MA0099.2 | 0.781628 |
| MA0079.2 | 4.96575 |
| MA0102.2 | 1.7182 |
| MA0258.1 | 0.790457 |
| MA0259.1 | 0.833237 |
| MA0442.1 | 0 |
