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CL:0000037

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Name:hematopoietic stem cell
Namespace:cell
Definition:"A stem cell from which all cells of the lymphoid and myeloid lineages develop, including blood cells and cells of the immune system. Hematopoietic stem cells lack cell markers of effector cells (lin-negative). Lin-negative is defined by lacking one or more of the following cell surface markers: CD2, CD3 epsilon, CD4, CD5 ,CD8 alpha chain, CD11b, CD14, CD19, CD20, CD56, ly6G, ter119." [GOC:add, GOC:DSD, GOC:tfm, PMID:19022770]
Xrefs:
links:

BTO:0000725
FMA:70337

FMA:86475
Synonyms: "blood forming stem cell" EXACT []
"colony forming unit hematopoietic" RELATED []
"hemopoietic stem cell" EXACT []
"HSC" EXACT []
Comments:Markers differ between species, and two sets of markers have been described for mice.


Ontology association <br>Each term has an is_a parent in the Cell ontology, which has a linkage to an another entity and FANTOM5 samples.Libraries were grouped into mutually exclusive facets according to the FANTOM5 sample ontology mapping to Cell ontologies.<br><br>link to ontology dataset<br>data

Parents

is_a:CL:0000048(multi fate stem cell),CL:0000988(hematopoietic cell)
develops_from:CL:0000566(angioblastic mesenchymal cell)



Children


is a:FF:0000028 (CD34-positive hematopoietic stem cell-CET),FF:0000029 (CD34-positive hematopoietic stem cell-3HBiomedical),CL:0001024 (CD34-positive, CD38-negative hematopoietic stem cell),CL:0002352 (gestational hematopoietic stem cell)
derives from:FF:0000021 (hematopoietic stem cell sample),FF:0200007 (H1 embryonic stem cells differentiation to CD34+ HSC sample),FF:0200027 (mouse (pre) hematopoietic stem cell,aorta-gonad-mesonephros (AGM) region derived sample),FF:0200028 (hematopoietic stem cell, placenta derived sample),FF:0200029 (hematopoietic stem cell, bone marrow derived sample)
develops from:CL:0000738 (leukocyte),CL:0000784 (plasmacytoid dendritic cell),CL:0000837 (hematopoietic multipotent progenitor cell)

Ontology Tree: Loaded from BioPortal

Ontorolgy tree(Small window open)


FF samples<br>It includes FANTOM5 samples that overlay the Cell ontology.

Human (Homo sapiens)

  • 11543-120B4
  • 11623-122B3
  • 11704-123B3
  • 11948-126B4 (Pre-hematopoietic stem cell, aorta-gonad-mesonephros (AGM) region derived, embryo E9.5)
  • 11949-126B5 (hematopoietic stem cell, aorta-gonad-mesonephros (AGM) region derived, embryo E10.5)
  • 11950-126B6 (hematopoietic stem cell, placenta derived, embryo E10.5)
  • 11951-126B7 (hematopoietic stem cell,aorta-gonad-mesonephros (AGM) region derived, embryo E11.5)
  • 11952-126B8 (hematopoietic stem cell, placenta derived, embryo E11.5)
  • 11953-126B9 (hematopoietic stem cell, fetal liver derived, embryo E12.5)
  • 11954-126C1 (hematopoietic stem cell, fetal liver derived, embryo E14.5)

... further results Mouse (Mus musculus)

  • 11543-120B4
  • 11623-122B3
  • 11704-123B3
  • 11948-126B4 (Pre-hematopoietic stem cell, aorta-gonad-mesonephros (AGM) region derived, embryo E9.5)
  • 11949-126B5 (hematopoietic stem cell, aorta-gonad-mesonephros (AGM) region derived, embryo E10.5)
  • 11950-126B6 (hematopoietic stem cell, placenta derived, embryo E10.5)
  • 11951-126B7 (hematopoietic stem cell,aorta-gonad-mesonephros (AGM) region derived, embryo E11.5)
  • 11952-126B8 (hematopoietic stem cell, placenta derived, embryo E11.5)
  • 11953-126B9 (hematopoietic stem cell, fetal liver derived, embryo E12.5)
  • 11954-126C1 (hematopoietic stem cell, fetal liver derived, embryo E14.5)

... further results


Enrichment analysis: top 100 FFCP enriched with this ontology termTOP 100 FANTOM5 Cage Peaks enriched with CL:0000037 (hematopoietic stem cell), sorted by p-values <br>Analyst: Hideya Kawaji<br><br>link to source dataset <br>human : data <br>mouse : data

P-valueFFCPShort description
3.0e-122FFCP PHASE2:Hg19::chr2:68592394..68592405,+#_c6d46bc6753c42512a10229001e4554ap2@PLEK
3.0e-122FFCP PHASE1:Hg19::chr2:68592394..68592405,+#_c6d46bc6753c42512a10229001e4554ap2@PLEK
1.27e-121FFCP PHASE1:Hg19::chr1:206730535..206730549,+#_60e62515623c719a59026d122f8cc4a6p4@RASSF5
1.27e-121FFCP PHASE2:Hg19::chr1:206730535..206730549,+#_60e62515623c719a59026d122f8cc4a6p4@RASSF5
3.52e-113FFCP PHASE1:Hg19::chr7:50344251..50344288,+#_e5293a98df22ffb4b8e5c9c143ae777fp3@IKZF1
3.52e-113FFCP PHASE2:Hg19::chr7:50344251..50344288,+#_e5293a98df22ffb4b8e5c9c143ae777fp3@IKZF1
3.7e-112FFCP PHASE1:Hg19::chr5:169724839..169724855,-#_07237b3424e1b22e2fe811e48c2017b2p3@LCP2
3.7e-112FFCP PHASE2:Hg19::chr5:169724839..169724855,-#_07237b3424e1b22e2fe811e48c2017b2p3@LCP2
1.39e-110FFCP PHASE2:Hg19::chr2:143886909..143886922,+#_3ec48dbb1f83b828b8cecff250210a01p2@ARHGAP15
1.39e-110FFCP PHASE1:Hg19::chr2:143886909..143886922,+#_3ec48dbb1f83b828b8cecff250210a01p2@ARHGAP15
1.11e-109FFCP PHASE2:Hg19::chr2:143886927..143886938,+#_9d3c362b9c0c0d584b69ea1281a66a16p3@ARHGAP15
1.11e-109FFCP PHASE1:Hg19::chr2:143886927..143886938,+#_9d3c362b9c0c0d584b69ea1281a66a16p3@ARHGAP15
1.73e-109FFCP PHASE2:Hg19::chr2:143886890..143886904,+#_36d6724dbec79f37a400f5fc91abc7d6p4@ARHGAP15
1.73e-109FFCP PHASE1:Hg19::chr2:143886890..143886904,+#_36d6724dbec79f37a400f5fc91abc7d6p4@ARHGAP15
8.77e-108FFCP PHASE1:Hg19::chr2:144021511..144021516,+#_4a9ac6793bc6d5a72445764aa4f6cf18p@chr2:144021511..144021516, +
8.77e-108FFCP PHASE2:Hg19::chr2:144021511..144021516,+#_4a9ac6793bc6d5a72445764aa4f6cf18p@chr2:144021511..144021516, +
2.18e-107FFCP PHASE1:Hg19::chr1:206730484..206730499,+#_de8aed830db606d45e644a99679fcc6cp2@RASSF5
2.18e-107FFCP PHASE2:Hg19::chr1:206730484..206730499,+#_de8aed830db606d45e644a99679fcc6cp2@RASSF5
9.44e-107FFCP PHASE1:Hg19::chr10:11207485..11207496,+#_c09c624744de5f391012e95957da53fap9@CELF2
9.44e-107FFCP PHASE2:Hg19::chr10:11207485..11207496,+#_c09c624744de5f391012e95957da53fap9@CELF2
4.49e-106FFCP PHASE1:Hg19::chr1:202129704..202129762,-#_a2e327aca2bb6e930405cf274660aa04p1@PTPN7
4.49e-106FFCP PHASE2:Hg19::chr1:202129704..202129762,-#_a2e327aca2bb6e930405cf274660aa04p1@PTPN7
9.63e-106FFCP PHASE2:Hg19::chr1:151129103..151129130,+#_29551029a20d56a0232700d27d3b5828p2@TNFAIP8L2
9.63e-106FFCP PHASE1:Hg19::chr1:151129103..151129130,+#_29551029a20d56a0232700d27d3b5828p2@TNFAIP8L2
1.59e-105FFCP PHASE2:Hg19::chr17:56415424..56415454,-#_cbce59e515d0bd586e9f68befeb6a986p@chr17:56415424..56415454, -
1.59e-105FFCP PHASE1:Hg19::chr17:56415424..56415454,-#_cbce59e515d0bd586e9f68befeb6a986p@chr17:56415424..56415454, -
2.83e-105FFCP PHASE2:Hg19::chr11:73694239..73694253,-#_5f37f18fef597887538e657bed7d9ca0p2@UCP2
2.83e-105FFCP PHASE1:Hg19::chr11:73694239..73694253,-#_5f37f18fef597887538e657bed7d9ca0p2@UCP2
4.44e-105FFCP PHASE2:Hg19::chr19:2085323..2085357,-#_010099221cff5d081d1dd4d2626a9348p2@MOB3A
4.44e-105FFCP PHASE1:Hg19::chr19:2085323..2085357,-#_010099221cff5d081d1dd4d2626a9348p2@MOB3A
3.52e-104FFCP PHASE1:Hg19::chr22:18260077..18260127,+#_031f23c53c6d3737287e0878be013188p1@LINC00528
3.52e-104FFCP PHASE2:Hg19::chr22:18260077..18260127,+#_031f23c53c6d3737287e0878be013188p1@LINC00528
6.12e-104FFCP PHASE1:Hg19::chr12:54891496..54891526,+#_388fc28897b85a10fab2494893608c2dp2@NCKAP1L
6.12e-104FFCP PHASE2:Hg19::chr12:54891496..54891526,+#_388fc28897b85a10fab2494893608c2dp2@NCKAP1L
9.57e-104FFCP PHASE1:Hg19::chr21:15918672..15918683,-#_c60816c3ecfb4ccc76a3ac125d8fb0ebp2@SAMSN1
9.57e-104FFCP PHASE2:Hg19::chr21:15918672..15918683,-#_c60816c3ecfb4ccc76a3ac125d8fb0ebp2@SAMSN1
1.14e-103FFCP PHASE1:Hg19::chr9:273038..273076,+#_27055429893cfed9d5d99420631d9bc4p2@DOCK8
1.14e-103FFCP PHASE2:Hg19::chr9:273038..273076,+#_27055429893cfed9d5d99420631d9bc4p2@DOCK8
1.33e-103FFCP PHASE2:Hg19::chr3:151962118..151962192,+#_de3421cc7d3eebf40a9d4f8f26acf102p@chr3:151962118..151962192, +
1.33e-103FFCP PHASE1:Hg19::chr3:151962118..151962192,+#_de3421cc7d3eebf40a9d4f8f26acf102p@chr3:151962118..151962192, +
2.11e-103FFCP PHASE2:Hg19::chr7:45018571..45018589,-#_582dfd0be793d5773fccc19649005669p3@MYO1G
2.11e-103FFCP PHASE1:Hg19::chr7:45018571..45018589,-#_582dfd0be793d5773fccc19649005669p3@MYO1G
3.12e-103FFCP PHASE1:Hg19::chr19:36393354..36393363,+#_ac9d286aecc6fd1fabe50a5dbd2df5a6p4@HCST
3.12e-103FFCP PHASE2:Hg19::chr19:36393354..36393363,+#_ac9d286aecc6fd1fabe50a5dbd2df5a6p4@HCST
3.81e-103FFCP PHASE2:Hg19::chr2:24149046..24149063,+#_1da08b53b69596dc40e8132cd2430776p@chr2:24149046..24149063, +
3.81e-103FFCP PHASE1:Hg19::chr2:24149046..24149063,+#_1da08b53b69596dc40e8132cd2430776p@chr2:24149046..24149063, +
4.59e-103FFCP PHASE1:Hg19::chr1:26872324..26872362,+#_8c408bc80bcf43770c286a8c15353451p1@RPS6KA1
4.59e-103FFCP PHASE2:Hg19::chr1:26872324..26872362,+#_8c408bc80bcf43770c286a8c15353451p1@RPS6KA1
9.07e-103FFCP PHASE2:Hg19::chr1:206730595..206730630,+#_9c1fa4b1422ec79db9d9cf1a36580c1fp3@RASSF5
9.07e-103FFCP PHASE1:Hg19::chr1:206730595..206730630,+#_9c1fa4b1422ec79db9d9cf1a36580c1fp3@RASSF5
3.05e-102FFCP PHASE2:Hg19::chr1:161039647..161039744,-#_3b5b13f455b81108152ee32039d6890fp1@ARHGAP30
3.05e-102FFCP PHASE1:Hg19::chr1:161039647..161039744,-#_3b5b13f455b81108152ee32039d6890fp1@ARHGAP30
3.67e-102FFCP PHASE1:Hg19::chr20:34078776..34078819,-#_341b113db247233ca1c1e1519a60afd0p1@ENST00000453914
3.67e-102FFCP PHASE2:Hg19::chr20:34078776..34078819,-#_341b113db247233ca1c1e1519a60afd0p1@ENST00000453914
6.88e-102FFCP PHASE2:Hg19::chr19:17862274..17862335,+#_2f7abebdc34acf0610dc55e450cfe8b0p2@FCHO1
6.88e-102FFCP PHASE1:Hg19::chr19:17862274..17862335,+#_2f7abebdc34acf0610dc55e450cfe8b0p2@FCHO1
8.32e-102FFCP PHASE2:Hg19::chr7:45018686..45018710,-#_ed4ed2f0e92553b82ea081f9efb1f00ap2@MYO1G
8.32e-102FFCP PHASE1:Hg19::chr7:45018686..45018710,-#_ed4ed2f0e92553b82ea081f9efb1f00ap2@MYO1G
1.35e-101FFCP PHASE2:Hg19::chr16:50715172..50715194,-#_5917d0eab84de19cd78a33fbf35d66ffp2@SNX20
1.35e-101FFCP PHASE1:Hg19::chr16:50715172..50715194,-#_5917d0eab84de19cd78a33fbf35d66ffp2@SNX20
1.39e-101FFCP PHASE2:Hg19::chr1:39680895..39680915,+#_b385e7169c5cc28eae11c01681b04207p7@MACF1
1.39e-101FFCP PHASE1:Hg19::chr1:39680895..39680915,+#_b385e7169c5cc28eae11c01681b04207p7@MACF1
1.9e-101FFCP PHASE1:Hg19::chr5:169064317..169064332,+#_0cb7b30aae961942b3d52fc82327c809p2@DOCK2
1.9e-101FFCP PHASE2:Hg19::chr5:169064317..169064332,+#_0cb7b30aae961942b3d52fc82327c809p2@DOCK2
3.02e-101FFCP PHASE2:Hg19::chr19:49842010..49842054,+#_c7aa1a9de31ac304fe87fe5d97f078bfp@chr19:49842010..49842054, +
3.02e-101FFCP PHASE1:Hg19::chr19:49842010..49842054,+#_c7aa1a9de31ac304fe87fe5d97f078bfp@chr19:49842010..49842054, +
5.86e-101FFCP PHASE1:Hg19::chr7:50343634..50343717,+#_3c300508c41e3ad3b244ae8282842eefp2@IKZF1
5.86e-101FFCP PHASE2:Hg19::chr7:50343634..50343717,+#_3c300508c41e3ad3b244ae8282842eefp2@IKZF1
6.38e-101FFCP PHASE2:Hg19::chr7:50344289..50344323,+#_8c7fdb20390c26cf27a00070555ac5fap1@IKZF1
6.38e-101FFCP PHASE1:Hg19::chr7:50344289..50344323,+#_8c7fdb20390c26cf27a00070555ac5fap1@IKZF1
9.04e-101FFCP PHASE2:Hg19::chr16:50715196..50715235,-#_68b39ce76f3e94c9c57d79b4cd719bd2p1@SNX20
9.04e-101FFCP PHASE1:Hg19::chr16:50715196..50715235,-#_68b39ce76f3e94c9c57d79b4cd719bd2p1@SNX20
9.27e-101FFCP PHASE1:Hg19::chrX:30595907..30595941,-#_6f1a44fbf7a504faa5c16429a4920d4ap2@CXorf21
9.27e-101FFCP PHASE2:Hg19::chrX:30595907..30595941,-#_6f1a44fbf7a504faa5c16429a4920d4ap2@CXorf21
1.17e-100FFCP PHASE1:Hg19::chr12:57871853..57871879,-#_0ff7fc28c5547590781d4e0bc2696164p6@ARHGAP9
1.17e-100FFCP PHASE2:Hg19::chr12:57871853..57871879,-#_0ff7fc28c5547590781d4e0bc2696164p6@ARHGAP9
1.51e-100FFCP PHASE2:Hg19::chr7:45018602..45018625,-#_704266fa60a8508025f9e919e8ff4b1fp1@MYO1G
1.51e-100FFCP PHASE1:Hg19::chr7:45018602..45018625,-#_704266fa60a8508025f9e919e8ff4b1fp1@MYO1G
2.45e-100FFCP PHASE2:Hg19::chr19:36393367..36393387,+#_eb48b0daf64ff914ac897669feb98d44p3@HCST
2.45e-100FFCP PHASE1:Hg19::chr19:36393367..36393387,+#_eb48b0daf64ff914ac897669feb98d44p3@HCST
2.86e-100FFCP PHASE2:Hg19::chr11:64107705..64107718,+#_8bbfab22723a74024ee018cd3d64f229p2@CCDC88B
2.86e-100FFCP PHASE1:Hg19::chr11:64107705..64107718,+#_8bbfab22723a74024ee018cd3d64f229p2@CCDC88B
3.34e-100FFCP PHASE2:Hg19::chrX:128913876..128913904,+#_ddae9dab80770c473b0cc9c16be71928p2@SASH3
3.34e-100FFCP PHASE1:Hg19::chrX:128913876..128913904,+#_ddae9dab80770c473b0cc9c16be71928p2@SASH3
9.16e-100FFCP PHASE1:Hg19::chr13:41593392..41593403,-#_cc35583332d96de1a59d5174dd6539c4p7@ELF1
9.16e-100FFCP PHASE2:Hg19::chr13:41593392..41593403,-#_cc35583332d96de1a59d5174dd6539c4p7@ELF1
9.96e-100FFCP PHASE2:Hg19::chr1:111415786..111415804,+#_1b1b3a746658976d7fbabc2c9681c939p2@CD53
9.96e-100FFCP PHASE1:Hg19::chr1:111415786..111415804,+#_1b1b3a746658976d7fbabc2c9681c939p2@CD53
1.19e-99FFCP PHASE2:Hg19::chr4:80994619..80994633,-#_bb78e72b543c2277034010c47f005712p6@ANTXR2
1.19e-99FFCP PHASE1:Hg19::chr4:80994619..80994633,-#_bb78e72b543c2277034010c47f005712p6@ANTXR2
1.86e-99FFCP PHASE1:Hg19::chr12:7060473..7060507,+#_9701548ee780ad606f134d58b1c4c24dp2@PTPN6
1.86e-99FFCP PHASE2:Hg19::chr12:7060473..7060507,+#_9701548ee780ad606f134d58b1c4c24dp2@PTPN6
1.89e-99FFCP PHASE1:Hg19::chr17:56414688..56414711,+#_f0f4956482e5eb0ac2a1abd47a841edap1@uc002iwa.2, p1@uc002iwb.2, p1@uc002iwc.2
1.89e-99FFCP PHASE2:Hg19::chr17:56414688..56414711,+#_f0f4956482e5eb0ac2a1abd47a841edap1@uc002iwa.2, p1@uc002iwb.2, p1@uc002iwc.2
2.51e-99FFCP PHASE1:Hg19::chr13:41593405..41593416,-#_120895aa2abfb5a80837ba292d004d31p9@ELF1
2.51e-99FFCP PHASE2:Hg19::chr13:41593405..41593416,-#_120895aa2abfb5a80837ba292d004d31p9@ELF1
2.65e-99FFCP PHASE2:Hg19::chr19:14551066..14551097,+#_e9aaf8bb477be93e0897b371dff33f9ep2@PKN1
2.65e-99FFCP PHASE1:Hg19::chr19:14551066..14551097,+#_e9aaf8bb477be93e0897b371dff33f9ep2@PKN1
7.96e-99FFCP PHASE2:Hg19::chr3:196366555..196366572,+#_bb767958eab259dc87efc0480795da6ep2@LRRC33
7.96e-99FFCP PHASE1:Hg19::chr3:196366555..196366572,+#_bb767958eab259dc87efc0480795da6ep2@LRRC33

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