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CL:0000115

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Name:endothelial cell
Namespace:FANTOM
Definition:"An endothelial cell comprises the outermost layer or lining of anatomical structures and can be squamous or cuboidal. In mammals, endothelial cell has vimentin filaments and is derived from the mesoderm." [GOC:tfm, http://63.198.234.228/OpenFMA/Endothelial%20cell.html, https://sourceforge.net/tracker/?func
Xrefs:
links:

BTO:0001176

FMA:66772
Synonyms: "endotheliocyte" EXACT []
Comments:From FMA: 9.07.2001: Endothelial cell has always been classified as a kind of epithelial cell, specifically a squamous cell but that is not true. First, endothelial cell can either be squamous or cuboidal (e.g. high-endothelial cell) and secondly, it has different embryological derivation (mesodermal) than a true epithelial cell (ectodermal and endodermal). The basis for present classification is the fact that it comprises the outermost layer or lining of anatomical structures (location-based) but a better structural basis for the differentia is the cytoskeleton of the cell. Endothelial cell has vimentin filaments while an epithelial cell has keratin filaments. [Onard].


Ontology association <br>Each term has an is_a parent in the Cell ontology, which has a linkage to an another entity and FANTOM5 samples.Libraries were grouped into mutually exclusive facets according to the FANTOM5 sample ontology mapping to Cell ontologies.<br><br>link to ontology dataset<br>data

Parents

is_a:CL:0000213(lining cell),CL:0002078(meso-epithelial cell)



Children


is a:CL:0002139 (endothelial cell of vascular tree),CL:0002188 (glomerular endothelial cell),CL:0002262 (endothelial cell of sinusoid),CL:0002367 (trabecular meshwork cell),FF:13595-146E4 (liver sinusoidal endothelial cells, sham operation, biol_rep1),FF:13596-146E5 (liver sinusoidal endothelial cells, sham operation, biol_rep2),FF:13597-146E6 (liver sinusoidal endothelial cells, sham operation, biol_rep3),FF:13598-146E7 (liver sinusoidal endothelial cells, partial hepatectomy, 02hr, biol_rep1),FF:13599-146E8 (liver sinusoidal endothelial cells, partial hepatectomy, 02hr, biol_rep2),FF:13600-146E9 (liver sinusoidal endothelial cells, partial hepatectomy, 02hr, biol_rep3),FF:13601-146F1 (liver sinusoidal endothelial cells, partial hepatectomy, 30hr, biol_rep1),FF:13602-146F2 (liver sinusoidal endothelial cells, partial hepatectomy, 30hr, biol_rep2),FF:13603-146F3 (liver sinusoidal endothelial cells, partial hepatectomy, 30hr, biol_rep3),FF:13604-146F4 (liver sinusoidal endothelial cells, partial hepatectomy, 48hr, biol_rep1),FF:13605-146F5 (liver sinusoidal endothelial cells, partial hepatectomy, 48hr, biol_rep2),FF:13606-146F6 (liver sinusoidal endothelial cells, partial hepatectomy, 48hr, biol_rep3),FF:13607-146F7 (liver sinusoidal endothelial cells, partial hepatectomy, week01, biol_rep1),FF:13608-146F8 (liver sinusoidal endothelial cells, partial hepatectomy, week01, biol_rep2),FF:13609-146F9 (liver sinusoidal endothelial cells, partial hepatectomy, week01, biol_rep3)
derives from:FF:0000046 (human endothelial cell sample)

Ontology Tree: Loaded from BioPortal

Ontorolgy tree(Small window open)


FF samples<br>It includes FANTOM5 samples that overlay the Cell ontology.

Human (Homo sapiens)

... further results Mouse (Mus musculus)

... further results


Enrichment analysis: top 100 FFCP enriched with this ontology termTOP 100 FANTOM5 Cage Peaks enriched with CL:0000115 (endothelial cell), sorted by p-values <br>Analyst: Hideya Kawaji<br><br>link to source dataset <br>human : data <br>mouse : data

P-valueFFCPShort description
9.88e-148FFCP PHASE1:Hg19::chr6:3753188..3753192,-#_06bc30e74497af619d61975e77d8eb98p@chr6:3753188..3753192, -
9.88e-148FFCP PHASE2:Hg19::chr6:3753188..3753192,-#_06bc30e74497af619d61975e77d8eb98p@chr6:3753188..3753192, -
1.61e-140FFCP PHASE1:Hg19::chr2:56216687..56216727,-#_fab41e54c2e336d47c48c7d6dee52670p1@MIR216A
1.61e-140FFCP PHASE2:Hg19::chr2:56216687..56216727,-#_fab41e54c2e336d47c48c7d6dee52670p1@MIR216A
6.06e-136FFCP PHASE2:Hg19::chr17:62084108..62084111,-#_9a0069514c9294f599f7e5cc7fbf874bp5@ICAM2
6.06e-136FFCP PHASE1:Hg19::chr17:62084108..62084111,-#_9a0069514c9294f599f7e5cc7fbf874bp5@ICAM2
9.36e-136FFCP PHASE2:Hg19::chr11:124761247..124761258,-#_85f7ac7e0263a7f05e6cc84e9456b9d2p@chr11:124761247..124761258, -
9.36e-136FFCP PHASE1:Hg19::chr11:124761247..124761258,-#_85f7ac7e0263a7f05e6cc84e9456b9d2p@chr11:124761247..124761258, -
8.29e-123FFCP PHASE2:Hg19::chr16:2220383..2220402,+#_0a24232b2879c978fc4e9db6fa2d5b69p@chr16:2220383..2220402, +
8.29e-123FFCP PHASE1:Hg19::chr16:2220383..2220402,+#_0a24232b2879c978fc4e9db6fa2d5b69p@chr16:2220383..2220402, +
7.69e-118FFCP PHASE1:Hg19::chrX:71299684..71299699,+#_9b523ba8e131c3ff26b28cd1106422ccp@chrX:71299684..71299699, +
7.69e-118FFCP PHASE2:Hg19::chrX:71299684..71299699,+#_9b523ba8e131c3ff26b28cd1106422ccp@chrX:71299684..71299699, +
8.89e-118FFCP PHASE2:Hg19::chr5:95920642..95920681,+#_21ce1d641a2177218ecff1a2973dc1c5p1@ENST00000513158
8.89e-118FFCP PHASE1:Hg19::chr5:95920642..95920681,+#_21ce1d641a2177218ecff1a2973dc1c5p1@ENST00000513158
2.23e-117FFCP PHASE2:Hg19::chr13:32835894..32835907,+#_785c732e886f06e401cd15af7c92f860p@chr13:32835894..32835907, +
2.23e-117FFCP PHASE1:Hg19::chr13:32835894..32835907,+#_785c732e886f06e401cd15af7c92f860p@chr13:32835894..32835907, +
3.21e-114FFCP PHASE2:Hg19::chr18:33047117..33047138,-#_381dcad6998a74e5410f9a824c731022p@chr18:33047117..33047138, -
3.21e-114FFCP PHASE1:Hg19::chr18:33047117..33047138,-#_381dcad6998a74e5410f9a824c731022p@chr18:33047117..33047138, -
5.66e-114FFCP PHASE1:Hg19::chr15:39423060..39423066,+#_9bcfe4f795a9e4c53d755f86ed810026p@chr15:39423060..39423066, +
5.66e-114FFCP PHASE2:Hg19::chr15:39423060..39423066,+#_9bcfe4f795a9e4c53d755f86ed810026p@chr15:39423060..39423066, +
5.52e-113FFCP PHASE2:Hg19::chr18:33046982..33046991,-#_684b3e4bb6885f0a1d1b627d7f2e3c99p@chr18:33046982..33046991, -
5.52e-113FFCP PHASE1:Hg19::chr18:33046982..33046991,-#_684b3e4bb6885f0a1d1b627d7f2e3c99p@chr18:33046982..33046991, -
4.6e-112FFCP PHASE1:Hg19::chrX:15518894..15518905,+#_16f64d24281979e3f09e9ffb7a1ff9b0p2@BMX
4.6e-112FFCP PHASE2:Hg19::chrX:15518894..15518905,+#_16f64d24281979e3f09e9ffb7a1ff9b0p2@BMX
2.66e-111FFCP PHASE2:Hg19::chr12:105863654..105863682,+#_25731f1147645a59858d91acc0ec7a96p@chr12:105863654..105863682, +
2.66e-111FFCP PHASE1:Hg19::chr12:105863654..105863682,+#_25731f1147645a59858d91acc0ec7a96p@chr12:105863654..105863682, +
1.63e-110FFCP PHASE2:Hg19::chr14:38725249..38725254,-#_e37384ebfd73de880ebb5562b9abcbcdp6@CLEC14A
1.63e-110FFCP PHASE1:Hg19::chr14:38725249..38725254,-#_e37384ebfd73de880ebb5562b9abcbcdp6@CLEC14A
7.97e-110FFCP PHASE1:Hg19::chr14:38725228..38725236,-#_a8b40fb330c1d3e81fba7f2f8ed0876bp5@CLEC14A
7.97e-110FFCP PHASE2:Hg19::chr14:38725228..38725236,-#_a8b40fb330c1d3e81fba7f2f8ed0876bp5@CLEC14A
6.56e-109FFCP PHASE2:Hg19::chr18:33047157..33047168,-#_6b2dc6ff68fb7578d5809bc92e1707c1p@chr18:33047157..33047168, -
6.56e-109FFCP PHASE1:Hg19::chr18:33047157..33047168,-#_6b2dc6ff68fb7578d5809bc92e1707c1p@chr18:33047157..33047168, -
7.47e-109FFCP PHASE2:Hg19::chr12:105863636..105863650,+#_8ad218010ff3980fae406f8e73352966p@chr12:105863636..105863650, +
7.47e-109FFCP PHASE1:Hg19::chr12:105863636..105863650,+#_8ad218010ff3980fae406f8e73352966p@chr12:105863636..105863650, +
1.87e-108FFCP PHASE1:Hg19::chr3:43538305..43538325,-#_66692a06d918de47eff75e48ef7cf4d1p@chr3:43538305..43538325, -
1.87e-108FFCP PHASE2:Hg19::chr3:43538305..43538325,-#_66692a06d918de47eff75e48ef7cf4d1p@chr3:43538305..43538325, -
1.97e-108FFCP PHASE1:Hg19::chr10:129785574..129785580,+#_f65ae4b4706cd3cd3f7135eedd961d5bp14@PTPRE
1.97e-108FFCP PHASE2:Hg19::chr10:129785574..129785580,+#_f65ae4b4706cd3cd3f7135eedd961d5bp14@PTPRE
2.37e-108FFCP PHASE1:Hg19::chr9:139543390..139543404,+#_246a11e56064fdca30885871771165afp@chr9:139543390..139543404, +
2.37e-108FFCP PHASE2:Hg19::chr9:139543390..139543404,+#_246a11e56064fdca30885871771165afp@chr9:139543390..139543404, +
9.99e-107FFCP PHASE2:Hg19::chr19:4639579..4639589,+#_07c5ca06b169e93ec9904b869098b483p2@TNFAIP8L1
9.99e-107FFCP PHASE1:Hg19::chr19:4639579..4639589,+#_07c5ca06b169e93ec9904b869098b483p2@TNFAIP8L1
5.19e-104FFCP PHASE2:Hg19::chr13:32835912..32835936,+#_a7d084e376072fc3d27dae6989cd2181p@chr13:32835912..32835936, +
5.19e-104FFCP PHASE1:Hg19::chr13:32835912..32835936,+#_a7d084e376072fc3d27dae6989cd2181p@chr13:32835912..32835936, +
8.89e-103FFCP PHASE2:Hg19::chr13:32838801..32838818,+#_e6d1da271bb41cc6b46da58bd6f8048ap9@FRY
8.89e-103FFCP PHASE1:Hg19::chr13:32838801..32838818,+#_e6d1da271bb41cc6b46da58bd6f8048ap9@FRY
3.87e-101FFCP PHASE2:Hg19::chr17:47287786..47287797,+#_beaba73ecc618e5758f5218112744586p4@ABI3
3.87e-101FFCP PHASE1:Hg19::chr17:47287786..47287797,+#_beaba73ecc618e5758f5218112744586p4@ABI3
1.92e-100FFCP PHASE2:Hg19::chr19:41985048..41985050,-#_c61c32af69712cdc8ae290920468e219p@chr19:41985048..41985050, -
1.92e-100FFCP PHASE1:Hg19::chr19:41985048..41985050,-#_c61c32af69712cdc8ae290920468e219p@chr19:41985048..41985050, -
9.53e-100FFCP PHASE2:Hg19::chr16:66413317..66413328,+#_de3d3861818eb9acef73a3d5a70e3250p1@AB385138
9.53e-100FFCP PHASE1:Hg19::chr16:66413317..66413328,+#_de3d3861818eb9acef73a3d5a70e3250p1@AB385138
9.54e-99FFCP PHASE2:Hg19::chr12:118112251..118112272,-#_6aa08e6bfd1d85a8e73a8f040411daebp12@KSR2
9.54e-99FFCP PHASE1:Hg19::chr12:118112251..118112272,-#_6aa08e6bfd1d85a8e73a8f040411daebp12@KSR2
2.11e-98FFCP PHASE1:Hg19::chr7:150329732..150329739,-#_5f3978443f6c36d83318fdb322df882fp8@GIMAP6
2.11e-98FFCP PHASE2:Hg19::chr7:150329732..150329739,-#_5f3978443f6c36d83318fdb322df882fp8@GIMAP6
1.26e-97FFCP PHASE1:Hg19::chr5:176433333..176433349,-#_ec81fa9cd193f97b0802ecbb0f1e2d93p11@UIMC1
1.26e-97FFCP PHASE2:Hg19::chr5:176433333..176433349,-#_ec81fa9cd193f97b0802ecbb0f1e2d93p11@UIMC1
4.26e-97FFCP PHASE2:Hg19::chr10:50153735..50153750,+#_f9bc43df97004d7f744aa7deee63561cp6@WDFY4
4.26e-97FFCP PHASE1:Hg19::chr10:50153735..50153750,+#_f9bc43df97004d7f744aa7deee63561cp6@WDFY4
5.01e-97FFCP PHASE2:Hg19::chr12:105863705..105863718,+#_6539287d81ebfcfefb27a97039d4d2d8p@chr12:105863705..105863718, +
5.01e-97FFCP PHASE1:Hg19::chr12:105863705..105863718,+#_6539287d81ebfcfefb27a97039d4d2d8p@chr12:105863705..105863718, +
3.98e-96FFCP PHASE2:Hg19::chr10:99655692..99655725,-#_51ba59a5683c8361aa6aa645b5701691p@chr10:99655692..99655725, -
3.98e-96FFCP PHASE1:Hg19::chr10:99655692..99655725,-#_51ba59a5683c8361aa6aa645b5701691p@chr10:99655692..99655725, -
8.76e-96FFCP PHASE2:Hg19::chr11:124767798..124767809,-#_68fa61fd333ba639cb688dc6931ca6c1p3@ROBO4
8.76e-96FFCP PHASE1:Hg19::chr11:124767798..124767809,-#_68fa61fd333ba639cb688dc6931ca6c1p3@ROBO4
1.94e-95FFCP PHASE2:Hg19::chr12:80084018..80084035,-#_64578b003dc87499ed0c1e19f3483119p17@PAWR
1.94e-95FFCP PHASE1:Hg19::chr12:80084018..80084035,-#_64578b003dc87499ed0c1e19f3483119p17@PAWR
6.54e-95FFCP PHASE2:Hg19::chr17:75137460..75137485,+#_f0fa33f8112dd683b0eccd4b617b414ap@chr17:75137460..75137485, +
6.54e-95FFCP PHASE1:Hg19::chr17:75137460..75137485,+#_f0fa33f8112dd683b0eccd4b617b414ap@chr17:75137460..75137485, +
1.27e-94FFCP PHASE2:Hg19::chr6:132455180..132455197,+#_ccf5128a2e6e14689f6343d2310460fcp2@LOC100507254
1.27e-94FFCP PHASE1:Hg19::chr6:132455180..132455197,+#_ccf5128a2e6e14689f6343d2310460fcp2@LOC100507254
1.3e-93FFCP PHASE2:Hg19::chr3:58034268..58034295,+#_65485d3061024adcf41fafa0db23adcdp@chr3:58034268..58034295, +
1.3e-93FFCP PHASE1:Hg19::chr3:58034268..58034295,+#_65485d3061024adcf41fafa0db23adcdp@chr3:58034268..58034295, +
1.98e-93FFCP PHASE1:Hg19::chr6:78171774..78171792,+#_90ab8e2a9b473a97de881613c2652f66p@chr6:78171774..78171792, +
1.98e-93FFCP PHASE2:Hg19::chr6:78171774..78171792,+#_90ab8e2a9b473a97de881613c2652f66p@chr6:78171774..78171792, +
1.01e-92FFCP PHASE2:Hg19::chr19:47220191..47220198,-#_56a3ccd9f872e025444523751eec91fep14@PRKD2
1.01e-92FFCP PHASE1:Hg19::chr19:47220191..47220198,-#_56a3ccd9f872e025444523751eec91fep14@PRKD2
1.93e-92FFCP PHASE2:Hg19::chr18:33047039..33047063,-#_b583652e47286b1cac8d3462d285a2fdp@chr18:33047039..33047063, -
1.93e-92FFCP PHASE1:Hg19::chr18:33047039..33047063,-#_b583652e47286b1cac8d3462d285a2fdp@chr18:33047039..33047063, -
2.0e-92FFCP PHASE1:Hg19::chr13:32838839..32838850,+#_0a111c3378aa97f5ed3ee9bf782840aep20@FRY
2.0e-92FFCP PHASE1:Hg19::chr7:139741594..139741615,-#_0a111c3378aa97f5ed3ee9bf782840aep5@PARP12
2.0e-92FFCP PHASE2:Hg19::chr7:139741594..139741615,-#_0a111c3378aa97f5ed3ee9bf782840aep5@PARP12
2.0e-92FFCP PHASE2:Hg19::chr18:33047076..33047099,-#_0a111c3378aa97f5ed3ee9bf782840aep@chr18:33047076..33047099, -
2.0e-92FFCP PHASE1:Hg19::chr18:33047076..33047099,-#_0a111c3378aa97f5ed3ee9bf782840aep@chr18:33047076..33047099, -
2.0e-92FFCP PHASE2:Hg19::chr13:32838839..32838850,+#_0a111c3378aa97f5ed3ee9bf782840aep20@FRY
6.65e-92FFCP PHASE2:Hg19::chr12:71031247..71031262,-#_4a40390335d2c543eefdf3784f1ff3dbp7@PTPRB
6.65e-92FFCP PHASE1:Hg19::chr12:71031247..71031262,-#_4a40390335d2c543eefdf3784f1ff3dbp7@PTPRB
1.75e-91FFCP PHASE2:Hg19::chr10:50153703..50153720,+#_6ca380c4836d4b130c90080dff551db7p7@WDFY4
1.75e-91FFCP PHASE1:Hg19::chr10:50153703..50153720,+#_6ca380c4836d4b130c90080dff551db7p7@WDFY4
2.48e-91FFCP PHASE2:Hg19::chr21:39869867..39869880,-#_b80cc45b9e6a64bf29bf6488c43165c0p@chr21:39869867..39869880, -
2.48e-91FFCP PHASE1:Hg19::chr21:39869867..39869880,-#_b80cc45b9e6a64bf29bf6488c43165c0p@chr21:39869867..39869880, -
5.09e-91FFCP PHASE2:Hg19::chr11:62344721..62344758,-#_8ca4b5923b1ca1721d461f978b2879d5p2@TUT1
5.09e-91FFCP PHASE1:Hg19::chr11:62344721..62344758,-#_8ca4b5923b1ca1721d461f978b2879d5p2@TUT1
1.11e-90FFCP PHASE2:Hg19::chr1:208063620..208063634,-#_931992a8819a1541b7815c9a4e82fbbap4@CD34
1.11e-90FFCP PHASE1:Hg19::chr1:208063620..208063634,-#_931992a8819a1541b7815c9a4e82fbbap4@CD34
1.26e-90FFCP PHASE2:Hg19::chr2:225266779..225266786,-#_97f6c73a7784fea0da7857c3c9bdd610p4@FAM124B
1.26e-90FFCP PHASE1:Hg19::chr2:225266779..225266786,-#_97f6c73a7784fea0da7857c3c9bdd610p4@FAM124B
2.6e-89FFCP PHASE1:Hg19::chr7:39663061..39663072,+#_36f5fa3e393cc28b9d225cc42eace732p6@RALA
2.6e-89FFCP PHASE2:Hg19::chr7:39663061..39663072,+#_36f5fa3e393cc28b9d225cc42eace732p6@RALA

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